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Items: 1 to 20 of 82

1.

The Snf1-related kinase, Hunk, is essential for mammary tumor metastasis.

Wertheim GB, Yang TW, Pan TC, Ramne A, Liu Z, Gardner HP, Dugan KD, Kristel P, Kreike B, van de Vijver MJ, Cardiff RD, Reynolds C, Chodosh LA.

Proc Natl Acad Sci U S A. 2009 Sep 15;106(37):15855-60. doi: 10.1073/pnas.0906993106. Epub 2009 Aug 28.

2.

Hunk is required for HER2/neu-induced mammary tumorigenesis.

Yeh ES, Yang TW, Jung JJ, Gardner HP, Cardiff RD, Chodosh LA.

J Clin Invest. 2011 Mar;121(3):866-79. doi: 10.1172/JCI42928.

3.

HUNK suppresses metastasis of basal type breast cancers by disrupting the interaction between PP2A and cofilin-1.

Quintela-Fandino M, Arpaia E, Brenner D, Goh T, Yeung FA, Blaser H, Alexandrova R, Lind EF, Tusche MW, Wakeham A, Ohashi PS, Mak TW.

Proc Natl Acad Sci U S A. 2010 Feb 9;107(6):2622-7. doi: 10.1073/pnas.0914492107. Epub 2010 Jan 22.

4.

Hormonally up-regulated neu-associated kinase: A novel target for breast cancer progression.

Zambrano JN, Neely BA, Yeh ES.

Pharmacol Res. 2017 May;119:188-194. doi: 10.1016/j.phrs.2017.02.007. Epub 2017 Feb 9. Review.

PMID:
28189783
5.

Developmental role of the SNF1-related kinase Hunk in pregnancy-induced changes in the mammary gland.

Gardner HP, Belka GK, Wertheim GB, Hartman JL, Ha SI, Gimotty PA, Marquis ST, Chodosh LA.

Development. 2000 Oct;127(20):4493-509.

6.

Hunk negatively regulates c-myc to promote Akt-mediated cell survival and mammary tumorigenesis induced by loss of Pten.

Yeh ES, Belka GK, Vernon AE, Chen CC, Jung JJ, Chodosh LA.

Proc Natl Acad Sci U S A. 2013 Apr 9;110(15):6103-8. doi: 10.1073/pnas.1217415110. Epub 2013 Mar 21.

7.

Hunk/Mak-v is a negative regulator of intestinal cell proliferation.

Reed KR, Korobko IV, Ninkina N, Korobko EV, Hopkins BR, Platt JL, Buchman V, Clarke AR.

BMC Cancer. 2015 Mar 8;15:110. doi: 10.1186/s12885-015-1087-2.

8.

Cloning and characterization of Hunk, a novel mammalian SNF1-related protein kinase.

Gardner HP, Wertheim GB, Ha SI, Copeland NG, Gilbert DJ, Jenkins NA, Marquis ST, Chodosh LA.

Genomics. 2000 Jan 1;63(1):46-59.

PMID:
10662544
10.

Mena deficiency delays tumor progression and decreases metastasis in polyoma middle-T transgenic mouse mammary tumors.

Roussos ET, Wang Y, Wyckoff JB, Sellers RS, Wang W, Li J, Pollard JW, Gertler FB, Condeelis JS.

Breast Cancer Res. 2010;12(6):R101. doi: 10.1186/bcr2784. Epub 2010 Nov 25.

12.

Caveolin-1 gene disruption promotes mammary tumorigenesis and dramatically enhances lung metastasis in vivo. Role of Cav-1 in cell invasiveness and matrix metalloproteinase (MMP-2/9) secretion.

Williams TM, Medina F, Badano I, Hazan RB, Hutchinson J, Muller WJ, Chopra NG, Scherer PE, Pestell RG, Lisanti MP.

J Biol Chem. 2004 Dec 3;279(49):51630-46. Epub 2004 Sep 7.

13.

The receptor tyrosine kinase EphA2 promotes mammary adenocarcinoma tumorigenesis and metastatic progression in mice by amplifying ErbB2 signaling.

Brantley-Sieders DM, Zhuang G, Hicks D, Fang WB, Hwang Y, Cates JM, Coffman K, Jackson D, Bruckheimer E, Muraoka-Cook RS, Chen J.

J Clin Invest. 2008 Jan;118(1):64-78.

14.

Inhibition of rho-associated kinase signaling prevents breast cancer metastasis to human bone.

Liu S, Goldstein RH, Scepansky EM, Rosenblatt M.

Cancer Res. 2009 Nov 15;69(22):8742-51. doi: 10.1158/0008-5472.CAN-09-1541. Epub 2009 Nov 3.

15.

Mammary epithelial-specific disruption of focal adhesion kinase retards tumor formation and metastasis in a transgenic mouse model of human breast cancer.

Provenzano PP, Inman DR, Eliceiri KW, Beggs HE, Keely PJ.

Am J Pathol. 2008 Nov;173(5):1551-65. doi: 10.2353/ajpath.2008.080308. Epub 2008 Oct 9.

16.

Mammary tumors expressing the neu proto-oncogene possess elevated c-Src tyrosine kinase activity.

Muthuswamy SK, Siegel PM, Dankort DL, Webster MA, Muller WJ.

Mol Cell Biol. 1994 Jan;14(1):735-43.

17.

Integrin-linked kinase has a critical role in ErbB2 mammary tumor progression: implications for human breast cancer.

Pontier SM, Huck L, White DE, Rayment J, Sanguin-Gendreau V, Hennessy B, Zuo D, St-Arnaud R, Mills GB, Dedhar S, Marshall CJ, Muller WJ.

Oncogene. 2010 Jun 10;29(23):3374-85. doi: 10.1038/onc.2010.86. Epub 2010 Mar 22.

PMID:
20305688
18.

Prolactin-induced mouse mammary carcinomas model estrogen resistant luminal breast cancer.

Arendt LM, Rugowski DE, Grafwallner-Huseth TA, Garcia-Barchino MJ, Rui H, Schuler LA.

Breast Cancer Res. 2011 Jan 28;13(1):R11. doi: 10.1186/bcr2819.

19.

Expression of MAK-V/Hunk in renal distal tubules and its possible involvement in proliferative suppression.

Sakai M, Tamura K, Tsurumi Y, Tanaka Y, Koide Y, Matsuda M, Ishigami T, Yabana M, Tokita Y, Hiroi Y, Komuro I, Umemura S.

Am J Physiol Renal Physiol. 2007 May;292(5):F1526-36. Epub 2007 Feb 13.

20.

Runx1 is associated with breast cancer progression in MMTV-PyMT transgenic mice and its depletion in vitro inhibits migration and invasion.

Browne G, Taipaleenmäki H, Bishop NM, Madasu SC, Shaw LM, van Wijnen AJ, Stein JL, Stein GS, Lian JB.

J Cell Physiol. 2015 Oct;230(10):2522-32. doi: 10.1002/jcp.24989.

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