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Items: 1 to 20 of 139

1.

Nerve agent analogues that produce authentic soman, sarin, tabun, and cyclohexyl methylphosphonate-modified human butyrylcholinesterase.

Gilley C, MacDonald M, Nachon F, Schopfer LM, Zhang J, Cashman JR, Lockridge O.

Chem Res Toxicol. 2009 Oct;22(10):1680-8. doi: 10.1021/tx900090m.

2.

Chemical synthesis of two series of nerve agent model compounds and their stereoselective interaction with human acetylcholinesterase and human butyrylcholinesterase.

Barakat NH, Zheng X, Gilley CB, MacDonald M, Okolotowicz K, Cashman JR, Vyas S, Beck JM, Hadad CM, Zhang J.

Chem Res Toxicol. 2009 Oct;22(10):1669-79. doi: 10.1021/tx900096j.

3.

Aging pathways for organophosphate-inhibited human butyrylcholinesterase, including novel pathways for isomalathion, resolved by mass spectrometry.

Li H, Schopfer LM, Nachon F, Froment MT, Masson P, Lockridge O.

Toxicol Sci. 2007 Nov;100(1):136-45. Epub 2007 Aug 13.

PMID:
17698511
4.

Detection of human butyrylcholinesterase-nerve gas adducts by liquid chromatography-mass spectrometric analysis after in gel chymotryptic digestion.

Tsuge K, Seto Y.

J Chromatogr B Analyt Technol Biomed Life Sci. 2006 Jun 21;838(1):21-30. Epub 2006 Mar 29.

PMID:
16569519
5.

Novel human butyrylcholinesterase variants: toward organophosphonate detoxication.

Dwyer M, Javor S, Ryan DA, Smith EM, Wang B, Zhang J, Cashman JR.

Biochemistry. 2014 Jul 15;53(27):4476-87. doi: 10.1021/bi500491w. Epub 2014 Jun 30.

6.

Crystal structures of brain group-VIII phospholipase A2 in nonaged complexes with the organophosphorus nerve agents soman and sarin.

Epstein TM, Samanta U, Kirby SD, Cerasoli DM, Bahnson BJ.

Biochemistry. 2009 Apr 21;48(15):3425-35. doi: 10.1021/bi8023527.

7.

Mass spectrometry method to identify aging pathways of Sp- and Rp-tabun adducts on human butyrylcholinesterase based on the acid labile P-N bond.

Jiang W, Cashman JR, Nachon F, Masson P, Schopfer LM, Lockridge O.

Toxicol Sci. 2013 Apr;132(2):390-8. doi: 10.1093/toxsci/kft011. Epub 2013 Jan 23.

8.

Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) for detection and identification of albumin phosphylation by organophosphorus pesticides and G- and V-type nerve agents.

John H, Breyer F, Thumfart JO, Höchstetter H, Thiermann H.

Anal Bioanal Chem. 2010 Nov;398(6):2677-91. doi: 10.1007/s00216-010-4076-y. Epub 2010 Aug 21.

PMID:
20730528
9.

Crystal structures of human group-VIIA phospholipase A2 inhibited by organophosphorus nerve agents exhibit non-aged complexes.

Samanta U, Kirby SD, Srinivasan P, Cerasoli DM, Bahnson BJ.

Biochem Pharmacol. 2009 Aug 15;78(4):420-9. doi: 10.1016/j.bcp.2009.04.018. Epub 2009 Apr 24.

10.

Degradation of nerve agents by an organophosphate-degrading agent (OpdA).

Dawson RM, Pantelidis S, Rose HR, Kotsonis SE.

J Hazard Mater. 2008 Sep 15;157(2-3):308-14. doi: 10.1016/j.jhazmat.2007.12.099. Epub 2008 Jan 4.

PMID:
18258361
11.

Formation of pyrophosphate-like adducts from nerve agents sarin, soman and cyclosarin in phosphate buffer: implications for analytical and toxicological investigations.

Gäb J, John H, Blum MM.

Toxicol Lett. 2011 Jan 15;200(1-2):34-40. doi: 10.1016/j.toxlet.2010.10.011. Epub 2010 Oct 25.

PMID:
20979985
12.

Modifications to the organophosphorus nerve agent-protein adduct refluoridation method for retrospective analysis of nerve agent exposures.

Holland KE, Solano MI, Johnson RC, Maggio VL, Barr JR.

J Anal Toxicol. 2008 Jan-Feb;32(1):116-24.

PMID:
18269803
13.
14.

Chiral separation of G-type chemical warfare nerve agents via analytical supercritical fluid chromatography.

Kasten SA, Zulli S, Jones JL, Dephillipo T, Cerasoli DM.

Chirality. 2014 Dec;26(12):817-24. doi: 10.1002/chir.22368. Epub 2014 Oct 9.

15.

Simultaneous measurement of tabun, sarin, soman, cyclosarin, VR, VX, and VM adducts to tyrosine in blood products by isotope dilution UHPLC-MS/MS.

Crow BS, Pantazides BG, Quiñones-González J, Garton JW, Carter MD, Perez JW, Watson CM, Tomcik DJ, Crenshaw MD, Brewer BN, Riches JR, Stubbs SJ, Read RW, Evans RA, Thomas JD, Blake TA, Johnson RC.

Anal Chem. 2014 Oct 21;86(20):10397-405. doi: 10.1021/ac502886c. Epub 2014 Oct 6.

16.
17.

Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry of titanium oxide-enriched peptides for detection of aged organophosphorus adducts on human butyrylcholinesterase.

Jiang W, Murashko EA, Dubrovskii YA, Podolskaya EP, Babakov VN, Mikler J, Nachon F, Masson P, Schopfer LM, Lockridge O.

Anal Biochem. 2013 Aug 15;439(2):132-41. doi: 10.1016/j.ab.2013.04.018. Epub 2013 Apr 25.

PMID:
23624322
18.

Organophosphorus nerve agents-induced seizures and efficacy of atropine sulfate as anticonvulsant treatment.

Shih TM, McDonough JH Jr.

Pharmacol Biochem Behav. 1999 Sep;64(1):147-53.

PMID:
10495009
19.

Identification of butyrylcholinesterase adducts after inhibition with isomalathion using mass spectrometry: difference in mechanism between (1R)- and (1S)-stereoisomers.

Doorn JA, Schall M, Gage DA, Talley TT, Thompson CM, Richardson RJ.

Toxicol Appl Pharmacol. 2001 Oct 15;176(2):73-80.

PMID:
11601883
20.

Stereoselective detoxification of chiral sarin and soman analogues by phosphotriesterase.

Li WS, Lum KT, Chen-Goodspeed M, Sogorb MA, Raushel FM.

Bioorg Med Chem. 2001 Aug;9(8):2083-91.

PMID:
11504644

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