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The E3 ligase TRAF6 regulates Akt ubiquitination and activation.

Yang WL, Wang J, Chan CH, Lee SW, Campos AD, Lamothe B, Hur L, Grabiner BC, Lin X, Darnay BG, Lin HK.

Science. 2009 Aug 28;325(5944):1134-8. doi: 10.1126/science.1175065.


The E3 ubiquitin ligase TRAF6 inhibits LPS-induced AKT activation in FLT3-ITD-positive MV4-11 AML cells.

Schnetzke U, Fischer M, Kuhn AK, Spies-Weisshart B, Zirm E, Hochhaus A, Müller JP, Scholl S.

J Cancer Res Clin Oncol. 2013 Apr;139(4):605-15. doi: 10.1007/s00432-012-1362-4. Epub 2012 Dec 21.


Cell signaling. Blocking Akt-ivity.

Restuccia DF, Hemmings BA.

Science. 2009 Aug 28;325(5944):1083-4. doi: 10.1126/science.1179972. No abstract available.


Ablation of Akt2 protects against lipopolysaccharide-induced cardiac dysfunction: role of Akt ubiquitination E3 ligase TRAF6.

Zhang Y, Xu X, Ceylan-Isik AF, Dong M, Pei Z, Li Y, Ren J.

J Mol Cell Cardiol. 2014 Sep;74:76-87. doi: 10.1016/j.yjmcc.2014.04.020. Epub 2014 May 5.


Ubiquitin-dependent regulation of phospho-AKT dynamics by the ubiquitin E3 ligase, NEDD4-1, in the insulin-like growth factor-1 response.

Fan CD, Lum MA, Xu C, Black JD, Wang X.

J Biol Chem. 2013 Jan 18;288(3):1674-84. doi: 10.1074/jbc.M112.416339. Epub 2012 Nov 29.


TRAF6-mediated ubiquitination of APPL1 enhances hepatic actions of insulin by promoting the membrane translocation of Akt.

Cheng KK, Lam KS, Wang Y, Wu D, Zhang M, Wang B, Li X, Hoo RL, Huang Z, Sweeney G, Xu A.

Biochem J. 2013 Oct 15;455(2):207-16. doi: 10.1042/BJ20130760.


CKIP-1 regulates macrophage proliferation by inhibiting TRAF6-mediated Akt activation.

Zhang L, Wang Y, Xiao F, Wang S, Xing G, Li Y, Yin X, Lu K, Wei R, Fan J, Chen Y, Li T, Xie P, Yuan L, Song L, Ma L, Ding L, He F, Zhang L.

Cell Res. 2014 Jun;24(6):742-61. doi: 10.1038/cr.2014.53. Epub 2014 Apr 29.


TRAF6 and the three C-terminal lysine sites on IRF7 are required for its ubiquitination-mediated activation by the tumor necrosis factor receptor family member latent membrane protein 1.

Ning S, Campos AD, Darnay BG, Bentz GL, Pagano JS.

Mol Cell Biol. 2008 Oct;28(20):6536-46. doi: 10.1128/MCB.00785-08. Epub 2008 Aug 18.


Protein phosphatase 4 negatively regulates LPS cascade by inhibiting ubiquitination of TRAF6.

Chen L, Dong W, Zou T, Ouyang L, He G, Liu Y, Qi Y.

FEBS Lett. 2008 Aug 20;582(19):2843-9. doi: 10.1016/j.febslet.2008.07.014. Epub 2008 Jul 15.


Lysine 63-linked polyubiquitination of TAK1 at lysine 158 is required for tumor necrosis factor alpha- and interleukin-1beta-induced IKK/NF-kappaB and JNK/AP-1 activation.

Fan Y, Yu Y, Shi Y, Sun W, Xie M, Ge N, Mao R, Chang A, Xu G, Schneider MD, Zhang H, Fu S, Qin J, Yang J.

J Biol Chem. 2010 Feb 19;285(8):5347-60. doi: 10.1074/jbc.M109.076976. Epub 2009 Dec 28.


Cycles of ubiquitination and deubiquitination critically regulate growth factor-mediated activation of Akt signaling.

Yang WL, Jin G, Li CF, Jeong YS, Moten A, Xu D, Feng Z, Chen W, Cai Z, Darnay B, Gu W, Lin HK.

Sci Signal. 2013 Jan 8;6(257):ra3. doi: 10.1126/scisignal.2003197.


Site-specific Lys-63-linked tumor necrosis factor receptor-associated factor 6 auto-ubiquitination is a critical determinant of I kappa B kinase activation.

Lamothe B, Besse A, Campos AD, Webster WK, Wu H, Darnay BG.

J Biol Chem. 2007 Feb 9;282(6):4102-12. Epub 2006 Nov 29.


TRAF6 promotes myogenic differentiation via the TAK1/p38 mitogen-activated protein kinase and Akt pathways.

Xiao F, Wang H, Fu X, Li Y, Wu Z.

PLoS One. 2012;7(4):e34081. doi: 10.1371/journal.pone.0034081. Epub 2012 Apr 4.


N6-Isopentenyladenosine promoted HeLa cell apoptosis through inhibitions of AKT and transforming growth factor β-activated kinase 1 activation.

Li M, Qi Y, Wei J, Lu L, Zhao X, Zhou L.

Tumour Biol. 2017 Mar;39(3):1010428317695966. doi: 10.1177/1010428317695966.


Identification of TRAF6 as a ubiquitin ligase engaged in the ubiquitination of SopB, a virulence effector protein secreted by Salmonella typhimurium.

Ruan HH, Li Y, Zhang XX, Liu Q, Ren H, Zhang KS, Zhao H.

Biochem Biophys Res Commun. 2014 Apr 25;447(1):172-7. doi: 10.1016/j.bbrc.2014.03.126. Epub 2014 Apr 2.


TRAF6 promotes ubiquitination and regulated intramembrane proteolysis of IL-1R1.

Twomey C, Qian S, McCarthy JV.

Biochem Biophys Res Commun. 2009 Apr 10;381(3):418-23. doi: 10.1016/j.bbrc.2009.02.051. Epub 2009 Feb 20.


HSP27 regulates IL-1 stimulated IKK activation through interacting with TRAF6 and affecting its ubiquitination.

Wu Y, Liu J, Zhang Z, Huang H, Shen J, Zhang S, Jiang Y, Luo L, Yin Z.

Cell Signal. 2009 Jan;21(1):143-50. doi: 10.1016/j.cellsig.2008.10.001. Epub 2008 Oct 10.


The E3 ligase TTC3 facilitates ubiquitination and degradation of phosphorylated Akt.

Suizu F, Hiramuki Y, Okumura F, Matsuda M, Okumura AJ, Hirata N, Narita M, Kohno T, Yokota J, Bohgaki M, Obuse C, Hatakeyama S, Obata T, Noguchi M.

Dev Cell. 2009 Dec;17(6):800-10. doi: 10.1016/j.devcel.2009.09.007.


A novel PTEN-dependent link to ubiquitination controls FLIPS stability and TRAIL sensitivity in glioblastoma multiforme.

Panner A, Crane CA, Weng C, Feletti A, Parsa AT, Pieper RO.

Cancer Res. 2009 Oct 15;69(20):7911-6. doi: 10.1158/0008-5472.CAN-09-1287. Epub 2009 Oct 6.


Role of growth arrest and DNA damage-inducible α in Akt phosphorylation and ubiquitination after mechanical stress-induced vascular injury.

Mitra S, Sammani S, Wang T, Boone DL, Meyer NJ, Dudek SM, Moreno-Vinasco L, Garcia JG, Jacobson JR.

Am J Respir Crit Care Med. 2011 Nov 1;184(9):1030-40. doi: 10.1164/rccm.201103-0447OC.

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