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Human papillomavirus 16 E7 oncoprotein attenuates DNA damage checkpoint control by increasing the proteolytic turnover of claspin.

Spardy N, Covella K, Cha E, Hoskins EE, Wells SI, Duensing A, Duensing S.

Cancer Res. 2009 Sep 1;69(17):7022-9. doi: 10.1158/0008-5472.CAN-09-0925. Epub 2009 Aug 25.


Polo-like kinase-1 controls proteasome-dependent degradation of Claspin during checkpoint recovery.

Mamely I, van Vugt MA, Smits VA, Semple JI, Lemmens B, Perrakis A, Medema RH, Freire R.

Curr Biol. 2006 Oct 10;16(19):1950-5. Epub 2006 Aug 24.


Polo-like kinase 1 activated by the hepatitis B virus X protein attenuates both the DNA damage checkpoint and DNA repair resulting in partial polyploidy.

Studach L, Wang WH, Weber G, Tang J, Hullinger RL, Malbrue R, Liu X, Andrisani O.

J Biol Chem. 2010 Sep 24;285(39):30282-93. doi: 10.1074/jbc.M109.093963. Epub 2010 Jul 12.


Genomic instability and cancer: lessons learned from human papillomaviruses.

Korzeniewski N, Spardy N, Duensing A, Duensing S.

Cancer Lett. 2011 Jun 28;305(2):113-22. doi: 10.1016/j.canlet.2010.10.013. Epub 2010 Nov 13. Review.


Human claspin is required for replication checkpoint control.

Chini CC, Chen J.

J Biol Chem. 2003 Aug 8;278(32):30057-62. Epub 2003 May 24.


Drosophila Claspin is required for the G2 arrest that is induced by DNA replication stress but not by DNA double-strand breaks.

Lee EM, Trinh TT, Shim HJ, Park SY, Nguyen TT, Kim MJ, Song YH.

DNA Repair (Amst). 2012 Sep 1;11(9):741-52. doi: 10.1016/j.dnarep.2012.06.007. Epub 2012 Jul 15.


Chk1- and claspin-dependent but ATR/ATM- and Rad17-independent DNA replication checkpoint response in HeLa cells.

Rodríguez-Bravo V, Guaita-Esteruelas S, Florensa R, Bachs O, Agell N.

Cancer Res. 2006 Sep 1;66(17):8672-9.


SCFbetaTrCP-mediated degradation of Claspin regulates recovery from the DNA replication checkpoint response.

Peschiaroli A, Dorrello NV, Guardavaccaro D, Venere M, Halazonetis T, Sherman NE, Pagano M.

Mol Cell. 2006 Aug 4;23(3):319-29.


Reconstitution of human claspin-mediated phosphorylation of Chk1 by the ATR (ataxia telangiectasia-mutated and rad3-related) checkpoint kinase.

Lindsey-Boltz LA, Serçin O, Choi JH, Sancar A.

J Biol Chem. 2009 Nov 27;284(48):33107-14. doi: 10.1074/jbc.M109.064485. Epub 2009 Oct 14.


Activation of Src, Fyn and Yes non-receptor tyrosine kinases in keratinocytes expressing human papillomavirus (HPV) type 16 E7 oncoprotein.

Szalmás A, Gyöngyösi E, Ferenczi A, László B, Karosi T, Csomor P, Gergely L, Veress G, Kónya J.

Virol J. 2013 Mar 7;10:79. doi: 10.1186/1743-422X-10-79.


Adaptation of a DNA replication checkpoint response depends upon inactivation of Claspin by the Polo-like kinase.

Yoo HY, Kumagai A, Shevchenko A, Shevchenko A, Dunphy WG.

Cell. 2004 May 28;117(5):575-88.


Claspin operates downstream of TopBP1 to direct ATR signaling towards Chk1 activation.

Liu S, Bekker-Jensen S, Mailand N, Lukas C, Bartek J, Lukas J.

Mol Cell Biol. 2006 Aug;26(16):6056-64.


Human papillomavirus E7 induces rereplication in response to DNA damage.

Fan X, Liu Y, Heilman SA, Chen JJ.

J Virol. 2013 Jan;87(2):1200-10. doi: 10.1128/JVI.02038-12. Epub 2012 Nov 14.


Claspin is phosphorylated in the Chk1-binding domain by a kinase distinct from Chk1.

Bennett LN, Larkin C, Gillespie DA, Clarke PR.

Biochem Biophys Res Commun. 2008 May 9;369(3):973-6. doi: 10.1016/j.bbrc.2008.02.154. Epub 2008 Mar 10.


Induction of tetraploidy through loss of p53 and upregulation of Plk1 by human papillomavirus type-16 E6.

Incassati A, Patel D, McCance DJ.

Oncogene. 2006 Apr 20;25(17):2444-51.


The Cdc14B-Cdh1-Plk1 axis controls the G2 DNA-damage-response checkpoint.

Bassermann F, Frescas D, Guardavaccaro D, Busino L, Peschiaroli A, Pagano M.

Cell. 2008 Jul 25;134(2):256-67. doi: 10.1016/j.cell.2008.05.043.

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