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Items: 1 to 20 of 280

1.

The identification of beta-hydroxy carboxylic acids as selective MMP-12 inhibitors.

Holmes IP, Gaines S, Watson SP, Lorthioir O, Walker A, Baddeley SJ, Herbert S, Egan D, Convery MA, Singh OM, Gross JW, Strelow JM, Smith RH, Amour AJ, Brown D, Martin SL.

Bioorg Med Chem Lett. 2009 Oct 1;19(19):5760-3. doi: 10.1016/j.bmcl.2009.07.155. Epub 2009 Aug 6.

PMID:
19703773
2.

Synthesis and SAR of alpha-sulfonylcarboxylic acids as potent matrix metalloproteinase inhibitors.

Zhang YM, Fan X, Xiang B, Chakravarty D, Scannevin R, Burke S, Karnachi P, Rhodes K, Jackson P.

Bioorg Med Chem Lett. 2006 Jun 15;16(12):3096-100. Epub 2006 May 2.

PMID:
16632358
3.

Design, synthesis, biological evaluation, and NMR studies of a new series of arylsulfones as selective and potent matrix metalloproteinase-12 inhibitors.

Nuti E, Panelli L, Casalini F, Avramova SI, Orlandini E, Santamaria S, Nencetti S, Tuccinardi T, Martinelli A, Cercignani G, D'Amelio N, Maiocchi A, Uggeri F, Rossello A.

J Med Chem. 2009 Oct 22;52(20):6347-61. doi: 10.1021/jm900335a.

PMID:
19775099
4.

Structural basis for the highly selective inhibition of MMP-13.

Engel CK, Pirard B, Schimanski S, Kirsch R, Habermann J, Klingler O, Schlotte V, Weithmann KU, Wendt KU.

Chem Biol. 2005 Feb;12(2):181-9.

5.

Structure-based design and synthesis of novel non-zinc chelating MMP-12 inhibitors.

Dublanchet AC, Ducrot P, Andrianjara C, O'Gara M, Morales R, Compère D, Denis A, Blais S, Cluzeau P, Courté K, Hamon J, Moreau F, Prunet ML, Tertre A.

Bioorg Med Chem Lett. 2005 Aug 15;15(16):3787-90.

PMID:
16002291
6.

Design, synthesis and evaluation of novel sulfonyl pyrrolidine derivatives as matrix metalloproteinase inhibitors.

Cheng XC, Wang Q, Fang H, Tang W, Xu WF.

Bioorg Med Chem. 2008 May 15;16(10):5398-404. doi: 10.1016/j.bmc.2008.04.027. Epub 2008 Apr 15.

PMID:
18440232
7.

Structure-based approach to nanomolar, water soluble matrix metalloproteinases inhibitors (MMPIs).

Attolino E, Calderone V, Dragoni E, Fragai M, Richichi B, Luchinat C, Nativi C.

Eur J Med Chem. 2010 Dec;45(12):5919-25. doi: 10.1016/j.ejmech.2010.09.057. Epub 2010 Oct 20.

PMID:
20965620
8.

Pyrimidine-2,4,6-Triones: a new effective and selective class of matrix metalloproteinase inhibitors.

Grams F, Brandstetter H, D'Alò S, Geppert D, Krell HW, Leinert H, Livi V, Menta E, Oliva A, Zimmermann G, Gram F, Brandstetter H, D'Alò S, Geppert D, Krell HW, Leinert H, Livi VMenta E, Oliva A, Zimmermann G.

Biol Chem. 2001 Aug;382(8):1277-85. Erratum in: Biol Chem 2001 Dec;382(12):1739.

PMID:
11592410
9.

Thiophene and bioisostere derivatives as new MMP12 inhibitors.

Badland M, Compère D, Courté K, Dublanchet AC, Blais S, Manage A, Peron G, Wrigglesworth R.

Bioorg Med Chem Lett. 2011 Jan 1;21(1):528-30. doi: 10.1016/j.bmcl.2010.10.087. Epub 2010 Nov 9.

PMID:
21111619
10.

Identification of potent and selective MMP-13 inhibitors.

Wu J, Rush TS 3rd, Hotchandani R, Du X, Geck M, Collins E, Xu ZB, Skotnicki J, Levin JI, Lovering FE.

Bioorg Med Chem Lett. 2005 Sep 15;15(18):4105-9.

PMID:
16005220
11.

Synthesis and SAR of highly selective MMP-13 inhibitors.

Li J, Rush TS 3rd, Li W, DeVincentis D, Du X, Hu Y, Thomason JR, Xiang JS, Skotnicki JS, Tam S, Cunningham KM, Chockalingam PS, Morris EA, Levin JI.

Bioorg Med Chem Lett. 2005 Nov 15;15(22):4961-6.

PMID:
16153831
12.

Synthesis and evaluation of new tripeptide phosphonate inhibitors of MMP-8 and MMP-2.

Agamennone M, Campestre C, Preziuso S, Consalvi V, Crucianelli M, Mazza F, Politi V, Ragno R, Tortorella P, Gallina C.

Eur J Med Chem. 2005 Mar;40(3):271-9. Epub 2005 Jan 19.

PMID:
15725496
13.

Pyrazole-based cathepsin S inhibitors with arylalkynes as P1 binding elements.

Ameriks MK, Axe FU, Bembenek SD, Edwards JP, Gu Y, Karlsson L, Randal M, Sun S, Thurmond RL, Zhu J.

Bioorg Med Chem Lett. 2009 Nov 1;19(21):6131-4. doi: 10.1016/j.bmcl.2009.09.014. Epub 2009 Sep 10.

PMID:
19773165
14.

Pyrazole-based cathepsin S inhibitors with improved cellular potency.

Wei J, Pio BA, Cai H, Meduna SP, Sun S, Gu Y, Jiang W, Thurmond RL, Karlsson L, Edwards JP.

Bioorg Med Chem Lett. 2007 Oct 15;17(20):5525-8. Epub 2007 Aug 22.

PMID:
17822900
15.

Synthesis of new sulfonyl pyrrolidine derivatives as matrix metalloproteinase inhibitors.

Cheng XC, Wang Q, Fang H, Tang W, Xu WF.

Bioorg Med Chem. 2008 Sep 1;16(17):7932-8. doi: 10.1016/j.bmc.2008.07.073. Epub 2008 Jul 30.

PMID:
18718763
16.

A novel series of highly selective inhibitors of MMP-3.

Whitlock GA, Dack KN, Dickinson RP, Lewis ML.

Bioorg Med Chem Lett. 2007 Dec 15;17(24):6750-3. Epub 2007 Oct 17.

PMID:
18029177
17.

Identification of an orally efficacious matrix metalloprotease 12 inhibitor for potential treatment of asthma.

Li W, Li J, Wu Y, Rancati F, Vallese S, Raveglia L, Wu J, Hotchandani R, Fuller N, Cunningham K, Morgan P, Fish S, Krykbaev R, Xu X, Tam S, Goldman SJ, Abraham W, Williams C, Sypek J, Mansour TS.

J Med Chem. 2009 Sep 10;52(17):5408-19. doi: 10.1021/jm900809r.

PMID:
19725580
18.

Discovery of potent, selective, and orally active carboxylic acid based inhibitors of matrix metalloproteinase-13.

Monovich LG, Tommasi RA, Fujimoto RA, Blancuzzi V, Clark K, Cornell WD, Doti R, Doughty J, Fang J, Farley D, Fitt J, Ganu V, Goldberg R, Goldstein R, Lavoie S, Kulathila R, Macchia W, Parker DT, Melton R, O'Byrne E, Pastor G, Pellas T, Quadros E, Reel N, Roland DM, Sakane Y, Singh H, Skiles J, Somers J, Toscano K, Wigg A, Zhou S, Zhu L, Shieh WC, Xue S, McQuire LW.

J Med Chem. 2009 Jun 11;52(11):3523-38. doi: 10.1021/jm801394m.

PMID:
19422229
19.

Selective MMP-12 inhibitors: WO-2008057254.

Norman P.

Expert Opin Ther Pat. 2009 Jul;19(7):1029-34. doi: 10.1517/13543770902815535.

PMID:
19456279
20.

Design of selective Cathepsin inhibitors.

Bethel PA, Gerhardt S, Jones EV, Kenny PW, Karoutchi GI, Morley AD, Oldham K, Rankine N, Augustin M, Krapp S, Simader H, Steinbacher S.

Bioorg Med Chem Lett. 2009 Aug 15;19(16):4622-5. doi: 10.1016/j.bmcl.2009.06.090. Epub 2009 Jun 27.

PMID:
19616430

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