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Items: 1 to 20 of 106

1.

Notch1 represses osteogenic pathways in aortic valve cells.

Nigam V, Srivastava D.

J Mol Cell Cardiol. 2009 Dec;47(6):828-34. doi: 10.1016/j.yjmcc.2009.08.008.

2.

Notch1 promotes the pro-osteogenic response of human aortic valve interstitial cells via modulation of ERK1/2 and nuclear factor-κB activation.

Zeng Q, Song R, Ao L, Weyant MJ, Lee J, Xu D, Fullerton DA, Meng X.

Arterioscler Thromb Vasc Biol. 2013 Jul;33(7):1580-90. doi: 10.1161/ATVBAHA.112.300912.

3.

Inhibitory role of Notch1 in calcific aortic valve disease.

Acharya A, Hans CP, Koenig SN, Nichols HA, Galindo CL, Garner HR, Merrill WH, Hinton RB, Garg V.

PLoS One. 2011;6(11):e27743. doi: 10.1371/journal.pone.0027743.

4.

Augmented osteogenic responses in human aortic valve cells exposed to oxLDL and TLR4 agonist: a mechanistic role of Notch1 and NF-κB interaction.

Zeng Q, Song R, Ao L, Xu D, Venardos N, Fullerton DA, Meng X.

PLoS One. 2014 May 8;9(5):e95400. doi: 10.1371/journal.pone.0095400.

5.

Endothelial nitric oxide signaling regulates Notch1 in aortic valve disease.

Bosse K, Hans CP, Zhao N, Koenig SN, Huang N, Guggilam A, LaHaye S, Tao G, Lucchesi PA, Lincoln J, Lilly B, Garg V.

J Mol Cell Cardiol. 2013 Jul;60:27-35. doi: 10.1016/j.yjmcc.2013.04.001.

6.

Notch1 Mutation Leads to Valvular Calcification Through Enhanced Myofibroblast Mechanotransduction.

Chen J, Ryzhova LM, Sewell-Loftin MK, Brown CB, Huppert SS, Baldwin HS, Merryman WD.

Arterioscler Thromb Vasc Biol. 2015 Jul;35(7):1597-605. doi: 10.1161/ATVBAHA.114.305095.

7.

Notch signaling pathway enhances bone morphogenetic protein 2 (BMP2) responsiveness of Msx2 gene to induce osteogenic differentiation and mineralization of vascular smooth muscle cells.

Shimizu T, Tanaka T, Iso T, Matsui H, Ooyama Y, Kawai-Kowase K, Arai M, Kurabayashi M.

J Biol Chem. 2011 May 27;286(21):19138-48. doi: 10.1074/jbc.M110.175786.

8.

NOTCH1 regulates matrix gla protein and calcification gene networks in human valve endothelium.

White MP, Theodoris CV, Liu L, Collins WJ, Blue KW, Lee JH, Meng X, Robbins RC, Ivey KN, Srivastava D.

J Mol Cell Cardiol. 2015 Jul;84:13-23. doi: 10.1016/j.yjmcc.2015.04.006.

9.

Activation of TLR3 induces osteogenic responses in human aortic valve interstitial cells through the NF-κB and ERK1/2 pathways.

Zhan Q, Song R, Zeng Q, Yao Q, Ao L, Xu D, Fullerton DA, Meng X.

Int J Biol Sci. 2015 Mar 20;11(4):482-93. doi: 10.7150/ijbs.10905.

10.

Pro-osteogenic phenotype of human aortic valve interstitial cells is associated with higher levels of Toll-like receptors 2 and 4 and enhanced expression of bone morphogenetic protein 2.

Yang X, Fullerton DA, Su X, Ao L, Cleveland JC Jr, Meng X.

J Am Coll Cardiol. 2009 Feb 10;53(6):491-500. doi: 10.1016/j.jacc.2008.09.052.

11.

Valvular interstitial cells suppress calcification of valvular endothelial cells.

Hjortnaes J, Shapero K, Goettsch C, Hutcheson JD, Keegan J, Kluin J, Mayer JE, Bischoff J, Aikawa E.

Atherosclerosis. 2015 Sep;242(1):251-60. doi: 10.1016/j.atherosclerosis.2015.07.008.

12.

ox-LDL induces PiT-1 expression in human aortic valve interstitial cells.

Nadlonek NA, Lee JH, Weyant MJ, Meng X, Fullerton DA.

J Surg Res. 2013 Sep;184(1):6-9. doi: 10.1016/j.jss.2013.05.001.

13.

Lack of periostin leads to suppression of Notch1 signaling and calcific aortic valve disease.

Tkatchenko TV, Moreno-Rodriguez RA, Conway SJ, Molkentin JD, Markwald RR, Tkatchenko AV.

Physiol Genomics. 2009 Nov 6;39(3):160-8. doi: 10.1152/physiolgenomics.00078.2009.

14.

Biglycan induces the expression of osteogenic factors in human aortic valve interstitial cells via Toll-like receptor-2.

Song R, Zeng Q, Ao L, Yu JA, Cleveland JC, Zhao KS, Fullerton DA, Meng X.

Arterioscler Thromb Vasc Biol. 2012 Nov;32(11):2711-20. doi: 10.1161/ATVBAHA.112.300116.

15.

Tumor necrosis factor-α accelerates the calcification of human aortic valve interstitial cells obtained from patients with calcific aortic valve stenosis via the BMP2-Dlx5 pathway.

Yu Z, Seya K, Daitoku K, Motomura S, Fukuda I, Furukawa K.

J Pharmacol Exp Ther. 2011 Apr;337(1):16-23. doi: 10.1124/jpet.110.177915.

16.

Diet-induced aortic valve disease in mice haploinsufficient for the Notch pathway effector RBPJK/CSL.

Nus M, MacGrogan D, Martínez-Poveda B, Benito Y, Casanova JC, Fernández-Avilés F, Bermejo J, de la Pompa JL.

Arterioscler Thromb Vasc Biol. 2011 Jul;31(7):1580-8. doi: 10.1161/ATVBAHA.111.227561.

17.

Mutations in NOTCH1 cause aortic valve disease.

Garg V, Muth AN, Ransom JF, Schluterman MK, Barnes R, King IN, Grossfeld PD, Srivastava D.

Nature. 2005 Sep 8;437(7056):270-4.

PMID:
16025100
18.

Endoplasmic reticulum stress participates in aortic valve calcification in hypercholesterolemic animals.

Cai Z, Li F, Gong W, Liu W, Duan Q, Chen C, Ni L, Xia Y, Cianflone K, Dong N, Wang DW.

Arterioscler Thromb Vasc Biol. 2013 Oct;33(10):2345-54. doi: 10.1161/ATVBAHA.112.300226.

19.

MicroRNA-30b is a multifunctional regulator of aortic valve interstitial cells.

Zhang M, Liu X, Zhang X, Song Z, Han L, He Y, Xu Z.

J Thorac Cardiovasc Surg. 2014 Mar;147(3):1073-1080.e2. doi: 10.1016/j.jtcvs.2013.05.011.

20.

Synergy between sphingosine 1-phosphate and lipopolysaccharide signaling promotes an inflammatory, angiogenic and osteogenic response in human aortic valve interstitial cells.

Fernández-Pisonero I, López J, Onecha E, Dueñas AI, Maeso P, Crespo MS, San Román JA, García-Rodríguez C.

PLoS One. 2014 Oct 2;9(9):e109081. doi: 10.1371/journal.pone.0109081.

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