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Cullin 1 functions as a centrosomal suppressor of centriole multiplication by regulating polo-like kinase 4 protein levels.

Korzeniewski N, Zheng L, Cuevas R, Parry J, Chatterjee P, Anderton B, Duensing A, Münger K, Duensing S.

Cancer Res. 2009 Aug 15;69(16):6668-75. doi: 10.1158/0008-5472.CAN-09-1284.


CAND1 promotes PLK4-mediated centriole overduplication and is frequently disrupted in prostate cancer.

Korzeniewski N, Hohenfellner M, Duensing S.

Neoplasia. 2012 Sep;14(9):799-806.


Centriole overduplication through the concurrent formation of multiple daughter centrioles at single maternal templates.

Duensing A, Liu Y, Perdreau SA, Kleylein-Sohn J, Nigg EA, Duensing S.

Oncogene. 2007 Sep 20;26(43):6280-8.


The HPV-16 E7 oncoprotein induces centriole multiplication through deregulation of Polo-like kinase 4 expression.

Korzeniewski N, Treat B, Duensing S.

Mol Cancer. 2011 May 24;10:61. doi: 10.1186/1476-4598-10-61.


The SCF Slimb ubiquitin ligase regulates Plk4/Sak levels to block centriole reduplication.

Rogers GC, Rusan NM, Roberts DM, Peifer M, Rogers SL.

J Cell Biol. 2009 Jan 26;184(2):225-39. doi: 10.1083/jcb.200808049.


Autophosphorylation of polo-like kinase 4 and its role in centriole duplication.

Sillibourne JE, Tack F, Vloemans N, Boeckx A, Thambirajah S, Bonnet P, Ramaekers FC, Bornens M, Grand-Perret T.

Mol Biol Cell. 2010 Feb 15;21(4):547-61. doi: 10.1091/mbc.E09-06-0505.


The C. elegans F-box proteins LIN-23 and SEL-10 antagonize centrosome duplication by regulating ZYG-1 levels.

Peel N, Dougherty M, Goeres J, Liu Y, O'Connell KF.

J Cell Sci. 2012 Aug 1;125(Pt 15):3535-44.


Plk4 trans-autophosphorylation regulates centriole number by controlling betaTrCP-mediated degradation.

Guderian G, Westendorf J, Uldschmid A, Nigg EA.

J Cell Sci. 2010 Jul 1;123(Pt 13):2163-9. doi: 10.1242/jcs.068502.


GCP6 is a substrate of Plk4 and required for centriole duplication.

Bahtz R, Seidler J, Arnold M, Haselmann-Weiss U, Antony C, Lehmann WD, Hoffmann I.

J Cell Sci. 2012 Jan 15;125(Pt 2):486-96. doi: 10.1242/jcs.093930.


Plk2 regulated centriole duplication is dependent on its localization to the centrioles and a functional polo-box domain.

Cizmecioglu O, Warnke S, Arnold M, Duensing S, Hoffmann I.

Cell Cycle. 2008 Nov 15;7(22):3548-55.


Polo-like kinase 4 kinase activity limits centrosome overduplication by autoregulating its own stability.

Holland AJ, Lan W, Niessen S, Hoover H, Cleveland DW.

J Cell Biol. 2010 Jan 25;188(2):191-8. doi: 10.1083/jcb.200911102.


The E3 ubiquitin ligase Mib1 regulates Plk4 and centriole biogenesis.

Čajánek L, Glatter T, Nigg EA.

J Cell Sci. 2015 May 1;128(9):1674-82. doi: 10.1242/jcs.166496.


Hierarchical recruitment of Plk4 and regulation of centriole biogenesis by two centrosomal scaffolds, Cep192 and Cep152.

Kim TS, Park JE, Shukla A, Choi S, Murugan RN, Lee JH, Ahn M, Rhee K, Bang JK, Kim BY, Loncarek J, Erikson RL, Lee KS.

Proc Natl Acad Sci U S A. 2013 Dec 10;110(50):E4849-57. doi: 10.1073/pnas.1319656110.


Cep152 acts as a scaffold for recruitment of Plk4 and CPAP to the centrosome.

Cizmecioglu O, Arnold M, Bahtz R, Settele F, Ehret L, Haselmann-Weiss U, Antony C, Hoffmann I.

J Cell Biol. 2010 Nov 15;191(4):731-9. doi: 10.1083/jcb.201007107.


The SCF-FBXW5 E3-ubiquitin ligase is regulated by PLK4 and targets HsSAS-6 to control centrosome duplication.

Puklowski A, Homsi Y, Keller D, May M, Chauhan S, Kossatz U, Grünwald V, Kubicka S, Pich A, Manns MP, Hoffmann I, Gönczy P, Malek NP.

Nat Cell Biol. 2011 Jul 3;13(8):1004-9. doi: 10.1038/ncb2282.


CDK11(p58) is required for centriole duplication and Plk4 recruitment to mitotic centrosomes.

Franck N, Montembault E, Romé P, Pascal A, Cremet JY, Giet R.

PLoS One. 2011 Jan 31;6(1):e14600. doi: 10.1371/journal.pone.0014600.


The Polo kinase Plk4 functions in centriole duplication.

Habedanck R, Stierhof YD, Wilkinson CJ, Nigg EA.

Nat Cell Biol. 2005 Nov;7(11):1140-6.


Asterless is a scaffold for the onset of centriole assembly.

Dzhindzhev NS, Yu QD, Weiskopf K, Tzolovsky G, Cunha-Ferreira I, Riparbelli M, Rodrigues-Martins A, Bettencourt-Dias M, Callaini G, Glover DM.

Nature. 2010 Oct 7;467(7316):714-8. doi: 10.1038/nature09445.


Centrobin-centrosomal protein 4.1-associated protein (CPAP) interaction promotes CPAP localization to the centrioles during centriole duplication.

Gudi R, Zou C, Dhar J, Gao Q, Vasu C.

J Biol Chem. 2014 May 30;289(22):15166-78. doi: 10.1074/jbc.M113.531152.


Human Cep192 and Cep152 cooperate in Plk4 recruitment and centriole duplication.

Sonnen KF, Gabryjonczyk AM, Anselm E, Stierhof YD, Nigg EA.

J Cell Sci. 2013 Jul 15;126(Pt 14):3223-33. doi: 10.1242/jcs.129502.

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