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Items: 1 to 20 of 100

1.

Anti-inflammatory treatment in AD mice protects against neuronal pathology.

Choi JK, Jenkins BG, Carreras I, Kaymakcalan S, Cormier K, Kowall NW, Dedeoglu A.

Exp Neurol. 2010 Jun;223(2):377-84. doi: 10.1016/j.expneurol.2009.07.032. Epub 2009 Aug 10.

2.

The effects of aging, housing and ibuprofen treatment on brain neurochemistry in a triple transgene Alzheimer's disease mouse model using magnetic resonance spectroscopy and imaging.

Choi JK, Carreras I, Aytan N, Jenkins-Sahlin E, Dedeoglu A, Jenkins BG.

Brain Res. 2014 Nov 24;1590:85-96. doi: 10.1016/j.brainres.2014.09.067. Epub 2014 Oct 6.

3.

Microglial activation and beta -amyloid deposit reduction caused by a nitric oxide-releasing nonsteroidal anti-inflammatory drug in amyloid precursor protein plus presenilin-1 transgenic mice.

Jantzen PT, Connor KE, DiCarlo G, Wenk GL, Wallace JL, Rojiani AM, Coppola D, Morgan D, Gordon MN.

J Neurosci. 2002 Mar 15;22(6):2246-54.

4.

Ibuprofen suppresses plaque pathology and inflammation in a mouse model for Alzheimer's disease.

Lim GP, Yang F, Chu T, Chen P, Beech W, Teter B, Tran T, Ubeda O, Ashe KH, Frautschy SA, Cole GM.

J Neurosci. 2000 Aug 1;20(15):5709-14.

5.

R-flurbiprofen improves tau, but not Aß pathology in a triple transgenic model of Alzheimer's disease.

Carreras I, McKee AC, Choi JK, Aytan N, Kowall NW, Jenkins BG, Dedeoglu A.

Brain Res. 2013 Dec 6;1541:115-27. doi: 10.1016/j.brainres.2013.10.025. Epub 2013 Oct 22.

7.

Anti-inflammatory drug therapy alters beta-amyloid processing and deposition in an animal model of Alzheimer's disease.

Yan Q, Zhang J, Liu H, Babu-Khan S, Vassar R, Biere AL, Citron M, Landreth G.

J Neurosci. 2003 Aug 20;23(20):7504-9.

8.

Ibuprofen suppresses interleukin-1beta induction of pro-amyloidogenic alpha1-antichymotrypsin to ameliorate beta-amyloid (Abeta) pathology in Alzheimer's models.

Morihara T, Teter B, Yang F, Lim GP, Boudinot S, Boudinot FD, Frautschy SA, Cole GM.

Neuropsychopharmacology. 2005 Jun;30(6):1111-20.

9.

Role of myo-inositol by magnetic resonance spectroscopy in early diagnosis of Alzheimer's disease in APP/PS1 transgenic mice.

Chen SQ, Wang PJ, Ten GJ, Zhan W, Li MH, Zang FC.

Dement Geriatr Cogn Disord. 2009;28(6):558-66. doi: 10.1159/000261646. Epub 2010 Jan 6.

10.

No improvement after chronic ibuprofen treatment in the 5XFAD mouse model of Alzheimer's disease.

Hillmann A, Hahn S, Schilling S, Hoffmann T, Demuth HU, Bulic B, Schneider-Axmann T, Bayer TA, Weggen S, Wirths O.

Neurobiol Aging. 2012 Apr;33(4):833.e39-50. doi: 10.1016/j.neurobiolaging.2011.08.006. Epub 2011 Sep 22.

PMID:
21943956
11.

NSAIDs prevent, but do not reverse, neuronal cell cycle reentry in a mouse model of Alzheimer disease.

Varvel NH, Bhaskar K, Kounnas MZ, Wagner SL, Yang Y, Lamb BT, Herrup K.

J Clin Invest. 2009 Dec;119(12):3692-702. doi: 10.1172/JCI39716. Epub 2009 Nov 9.

12.

Modulation of nuclear factor-kappa B activity by indomethacin influences A beta levels but not A beta precursor protein metabolism in a model of Alzheimer's disease.

Sung S, Yang H, Uryu K, Lee EB, Zhao L, Shineman D, Trojanowski JQ, Lee VM, Praticò D.

Am J Pathol. 2004 Dec;165(6):2197-206.

13.

A subset of NSAIDs lower amyloidogenic Abeta42 independently of cyclooxygenase activity.

Weggen S, Eriksen JL, Das P, Sagi SA, Wang R, Pietrzik CU, Findlay KA, Smith TE, Murphy MP, Bulter T, Kang DE, Marquez-Sterling N, Golde TE, Koo EH.

Nature. 2001 Nov 8;414(6860):212-6.

PMID:
11700559
14.

Identification and modification of amyloid-independent phenotypes of APOE4 mice.

DiBattista AM, Dumanis SB, Newman J, Rebeck GW.

Exp Neurol. 2016 Jun;280:97-105. doi: 10.1016/j.expneurol.2016.04.014. Epub 2016 Apr 14.

15.

Age-related amyloid beta deposition in transgenic mice overexpressing both Alzheimer mutant presenilin 1 and amyloid beta precursor protein Swedish mutant is not associated with global neuronal loss.

Takeuchi A, Irizarry MC, Duff K, Saido TC, Hsiao Ashe K, Hasegawa M, Mann DM, Hyman BT, Iwatsubo T.

Am J Pathol. 2000 Jul;157(1):331-9. Erratum in: Am J Pathol 2000 Oct;157(4):1413.

16.

Acute treatment with the PPARgamma agonist pioglitazone and ibuprofen reduces glial inflammation and Abeta1-42 levels in APPV717I transgenic mice.

Heneka MT, Sastre M, Dumitrescu-Ozimek L, Hanke A, Dewachter I, Kuiperi C, O'Banion K, Klockgether T, Van Leuven F, Landreth GE.

Brain. 2005 Jun;128(Pt 6):1442-53. Epub 2005 Apr 7.

PMID:
15817521
17.

CHF5074, a novel gamma-secretase modulator, attenuates brain beta-amyloid pathology and learning deficit in a mouse model of Alzheimer's disease.

Imbimbo BP, Hutter-Paier B, Villetti G, Facchinetti F, Cenacchi V, Volta R, Lanzillotta A, Pizzi M, Windisch M.

Br J Pharmacol. 2009 Mar;156(6):982-93. doi: 10.1111/j.1476-5381.2008.00097.x.

18.

Cyclooxygenase-2 inhibition improves amyloid-beta-mediated suppression of memory and synaptic plasticity.

Kotilinek LA, Westerman MA, Wang Q, Panizzon K, Lim GP, Simonyi A, Lesne S, Falinska A, Younkin LH, Younkin SG, Rowan M, Cleary J, Wallis RA, Sun GY, Cole G, Frautschy S, Anwyl R, Ashe KH.

Brain. 2008 Mar;131(Pt 3):651-64. doi: 10.1093/brain/awn008.

19.

Ibuprofen effects on Alzheimer pathology and open field activity in APPsw transgenic mice.

Lim GP, Yang F, Chu T, Gahtan E, Ubeda O, Beech W, Overmier JB, Hsiao-Ashec K, Frautschy SA, Cole GM.

Neurobiol Aging. 2001 Nov-Dec;22(6):983-91.

PMID:
11755007
20.

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