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Coordination between polymerase beta and FEN1 can modulate CAG repeat expansion.

Liu Y, Prasad R, Beard WA, Hou EW, Horton JK, McMurray CT, Wilson SH.

J Biol Chem. 2009 Oct 9;284(41):28352-66. doi: 10.1074/jbc.M109.050286. Epub 2009 Aug 11.


Proliferating cell nuclear antigen prevents trinucleotide repeat expansions by promoting repeat deletion and hairpin removal.

Beaver JM, Lai Y, Rolle SJ, Liu Y.

DNA Repair (Amst). 2016 Dec;48:17-29. doi: 10.1016/j.dnarep.2016.10.006. Epub 2016 Oct 22.


DNA base excision repair: a mechanism of trinucleotide repeat expansion.

Liu Y, Wilson SH.

Trends Biochem Sci. 2012 Apr;37(4):162-72. doi: 10.1016/j.tibs.2011.12.002. Epub 2012 Jan 27. Review.


Trinucleotide repeat deletion via a unique hairpin bypass by DNA polymerase β and alternate flap cleavage by flap endonuclease 1.

Xu M, Gabison J, Liu Y.

Nucleic Acids Res. 2013 Feb 1;41(3):1684-97. doi: 10.1093/nar/gks1306. Epub 2012 Dec 20.


Stoichiometry of base excision repair proteins correlates with increased somatic CAG instability in striatum over cerebellum in Huntington's disease transgenic mice.

Goula AV, Berquist BR, Wilson DM 3rd, Wheeler VC, Trottier Y, Merienne K.

PLoS Genet. 2009 Dec;5(12):e1000749. doi: 10.1371/journal.pgen.1000749. Epub 2009 Dec 4.


DNA polymerase beta and flap endonuclease 1 enzymatic specificities sustain DNA synthesis for long patch base excision repair.

Liu Y, Beard WA, Shock DD, Prasad R, Hou EW, Wilson SH.

J Biol Chem. 2005 Feb 4;280(5):3665-74. Epub 2004 Nov 22.


Base excision repair of oxidative DNA damage coupled with removal of a CAG repeat hairpin attenuates trinucleotide repeat expansion.

Xu M, Lai Y, Torner J, Zhang Y, Zhang Z, Liu Y.

Nucleic Acids Res. 2014 Apr;42(6):3675-91. doi: 10.1093/nar/gkt1372. Epub 2014 Jan 14.


FEN1 stimulation of DNA polymerase beta mediates an excision step in mammalian long patch base excision repair.

Prasad R, Dianov GL, Bohr VA, Wilson SH.

J Biol Chem. 2000 Feb 11;275(6):4460-6.


The nucleotide sequence, DNA damage location, and protein stoichiometry influence the base excision repair outcome at CAG/CTG repeats.

Goula AV, Pearson CE, Della Maria J, Trottier Y, Tomkinson AE, Wilson DM 3rd, Merienne K.

Biochemistry. 2012 May 8;51(18):3919-32. doi: 10.1021/bi300410d. Epub 2012 Apr 23.


Expansion of CAG triplet repeats by human DNA polymerases λ and β in vitro, is regulated by flap endonuclease 1 and DNA ligase 1.

Crespan E, Hübscher U, Maga G.

DNA Repair (Amst). 2015 May;29:101-11. doi: 10.1016/j.dnarep.2015.01.005. Epub 2015 Jan 29.


Poly(ADP-ribose) polymerase 1 regulates activity of DNA polymerase beta in long patch base excision repair.

Sukhanova M, Khodyreva S, Lavrik O.

Mutat Res. 2010 Mar 1;685(1-2):80-9. doi: 10.1016/j.mrfmmm.2009.08.009. Epub 2009 Aug 22.


HMGB1 Stimulates Activity of Polymerase β on Nucleosome Substrates.

Balliano A, Hao F, Njeri C, Balakrishnan L, Hayes JJ.

Biochemistry. 2017 Jan 31;56(4):647-656. doi: 10.1021/acs.biochem.6b00569. Epub 2017 Jan 18.


Comparison of functional properties of mammalian DNA polymerase lambda and DNA polymerase beta in reactions of DNA synthesis related to DNA repair.

Lebedeva NA, Rechkunova NI, Dezhurov SV, Khodyreva SN, Favre A, Blanco L, Lavrik OI.

Biochim Biophys Acta. 2005 Aug 10;1751(2):150-8.


HMGB1 is a cofactor in mammalian base excision repair.

Prasad R, Liu Y, Deterding LJ, Poltoratsky VP, Kedar PS, Horton JK, Kanno S, Asagoshi K, Hou EW, Khodyreva SN, Lavrik OI, Tomer KB, Yasui A, Wilson SH.

Mol Cell. 2007 Sep 7;27(5):829-41.


Initiation of 8-oxoguanine base excision repair within trinucleotide tandem repeats.

Derevyanko AG, Endutkin AV, Ishchenko AA, Saparbaev MK, Zharkov DO.

Biochemistry (Mosc). 2012 Mar;77(3):270-9. doi: 10.1134/S0006297912030054.


APE1-dependent repair of DNA single-strand breaks containing 3'-end 8-oxoguanine.

Parsons JL, Dianova II, Dianov GL.

Nucleic Acids Res. 2005 Apr 14;33(7):2204-9. Print 2005.


Instability of CTG repeats is governed by the position of a DNA base lesion through base excision repair.

Lai Y, Xu M, Zhang Z, Liu Y.

PLoS One. 2013;8(2):e56960. doi: 10.1371/journal.pone.0056960. Epub 2013 Feb 26.

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