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Items: 1 to 20 of 122


Genetic evidence for the role of Erk activation in a lymphoproliferative disease of mice.

Miyaji M, Kortum RL, Surana R, Li W, Woolard KD, Simpson RM, Samelson LE, Sommers CL.

Proc Natl Acad Sci U S A. 2009 Aug 25;106(34):14502-7. doi: 10.1073/pnas.0903894106. Epub 2009 Aug 10.


Mutation of the phospholipase C-gamma1-binding site of LAT affects both positive and negative thymocyte selection.

Sommers CL, Lee J, Steiner KL, Gurson JM, Depersis CL, El-Khoury D, Fuller CL, Shores EW, Love PE, Samelson LE.

J Exp Med. 2005 Apr 4;201(7):1125-34. Epub 2005 Mar 28.


A phospholipase C-γ1-independent, RasGRP1-ERK-dependent pathway drives lymphoproliferative disease in linker for activation of T cells-Y136F mutant mice.

Kortum RL, Rouquette-Jazdanian AK, Miyaji M, Merrill RK, Markegard E, Pinski JM, Wesselink A, Nath NN, Alexander CP, Li W, Kedei N, Roose JP, Blumberg PM, Samelson LE, Sommers CL.

J Immunol. 2013 Jan 1;190(1):147-58. doi: 10.4049/jimmunol.1201458. Epub 2012 Dec 3.


The role of the LAT-PLC-gamma1 interaction in T regulatory cell function.

Chuck MI, Zhu M, Shen S, Zhang W.

J Immunol. 2010 Mar 1;184(5):2476-86. doi: 10.4049/jimmunol.0902876. Epub 2010 Feb 3.


miR-155 Controls Lymphoproliferation in LAT Mutant Mice by Restraining T-Cell Apoptosis via SHIP-1/mTOR and PAK1/FOXO3/BIM Pathways.

Rouquette-Jazdanian AK, Kortum RL, Li W, Merrill RK, Nguyen PH, Samelson LE, Sommers CL.

PLoS One. 2015 Jun 29;10(6):e0131823. doi: 10.1371/journal.pone.0131823. eCollection 2015.


Bam32: a novel mediator of Erk activation in T cells.

Sommers CL, Gurson JM, Surana R, Barda-Saad M, Lee J, Kishor A, Li W, Gasser AJ, Barr VA, Miyaji M, Love PE, Samelson LE.

Int Immunol. 2008 Jul;20(7):811-8. doi: 10.1093/intimm/dxn039. Epub 2008 Apr 29.


The Importance of IL-6 in the Development of LAT-Mediated Autoimmunity.

O'Brien SA, Zhu M, Zhang W.

J Immunol. 2015 Jul 15;195(2):695-705. doi: 10.4049/jimmunol.1403187. Epub 2015 Jun 1.


A LAT mutation that inhibits T cell development yet induces lymphoproliferation.

Sommers CL, Park CS, Lee J, Feng C, Fuller CL, Grinberg A, Hildebrand JA, Lacaná E, Menon RK, Shores EW, Samelson LE, Love PE.

Science. 2002 Jun 14;296(5575):2040-3.


The role of LAT-PLCγ1 interaction in γδ T cell development and homeostasis.

Sullivan SA, Zhu M, Bao S, Lewis CA, Ou-Yang CW, Zhang W.

J Immunol. 2014 Mar 15;192(6):2865-74. doi: 10.4049/jimmunol.1302493. Epub 2014 Feb 12.


LAT-independent Erk activation via Bam32-PLC-γ1-Pak1 complexes: GTPase-independent Pak1 activation.

Rouquette-Jazdanian AK, Sommers CL, Kortum RL, Morrison DK, Samelson LE.

Mol Cell. 2012 Oct 26;48(2):298-312. doi: 10.1016/j.molcel.2012.08.011. Epub 2012 Sep 13.


LAT alleviates Th2/Treg imbalance in an OVA-induced allergic asthma mouse model through LAT-PLC-γ1 interaction.

Chen X, Li XM, Gu W, Wang D, Chen Y, Guo XJ.

Int Immunopharmacol. 2017 Mar;44:9-15. doi: 10.1016/j.intimp.2016.12.029. Epub 2017 Jan 4.


The ability of Sos1 to oligomerize the adaptor protein LAT is separable from its guanine nucleotide exchange activity in vivo.

Kortum RL, Balagopalan L, Alexander CP, Garcia J, Pinski JM, Merrill RK, Nguyen PH, Li W, Agarwal I, Akpan IO, Sommers CL, Samelson LE.

Sci Signal. 2013 Nov 12;6(301):ra99. doi: 10.1126/scisignal.2004494.


The importance of the Erk pathway in the development of linker for activation of T cells-mediated autoimmunity.

Fuller DM, Zhu M, Koonpaew S, Nelson MI, Zhang W.

J Immunol. 2012 Oct 15;189(8):4005-13. doi: 10.4049/jimmunol.1201380. Epub 2012 Sep 14.


Loss of the LAT adaptor converts antigen-responsive T cells into pathogenic effectors that function independently of the T cell receptor.

Mingueneau M, Roncagalli R, Grégoire C, Kissenpfennig A, Miazek A, Archambaud C, Wang Y, Perrin P, Bertosio E, Sansoni A, Richelme S, Locksley RM, Aguado E, Malissen M, Malissen B.

Immunity. 2009 Aug 21;31(2):197-208. doi: 10.1016/j.immuni.2009.05.013. Epub 2009 Aug 13.


STAT6 deletion converts the Th2 inflammatory pathology afflicting Lat(Y136F) mice into a lymphoproliferative disorder involving Th1 and CD8 effector T cells.

Archambaud C, Sansoni A, Mingueneau M, Devilard E, Delsol G, Malissen B, Malissen M.

J Immunol. 2009 Mar 1;182(5):2680-9. doi: 10.4049/jimmunol.0803257.


Th2 lymphoproliferative disorder of LatY136F mutant mice unfolds independently of TCR-MHC engagement and is insensitive to the action of Foxp3+ regulatory T cells.

Wang Y, Kissenpfennig A, Mingueneau M, Richelme S, Perrin P, Chevrier S, Genton C, Lucas B, DiSanto JP, Acha-Orbea H, Malissen B, Malissen M.

J Immunol. 2008 Feb 1;180(3):1565-75.


Knock-in mutation of the distal four tyrosines of linker for activation of T cells blocks murine T cell development.

Sommers CL, Menon RK, Grinberg A, Zhang W, Samelson LE, Love PE.

J Exp Med. 2001 Jul 16;194(2):135-42.


Serine residues in the LAT adaptor are essential for TCR-dependent signal transduction.

Martínez-Florensa M, García-Blesa A, Yélamos J, Muñoz-Suano A, Domínguez-Villar M, Valdor R, Alonso A, García-Cózar F, Aparicio P, Malissen B, Aguado E.

J Leukoc Biol. 2011 Jan;89(1):63-73. doi: 10.1189/jlb.0509342. Epub 2010 Oct 12.


Contributions of the T cell receptor-associated CD3gamma-ITAM to thymocyte selection.

Haks MC, Pépin E, van den Brakel JH, Smeele SA, Belkowski SM, Kessels HW, Krimpenfort P, Kruisbeek AM.

J Exp Med. 2002 Jul 1;196(1):1-13.

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