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Ca2+ binding by domain 2 plays a critical role in the activation and stabilization of gelsolin.

Nag S, Ma Q, Wang H, Chumnarnsilpa S, Lee WL, Larsson M, Kannan B, Hernandez-Valladares M, Burtnick LD, Robinson RC.

Proc Natl Acad Sci U S A. 2009 Aug 18;106(33):13713-8. doi: 10.1073/pnas.0812374106. Epub 2009 Aug 4.


The calcium activation of gelsolin: insights from the 3A structure of the G4-G6/actin complex.

Choe H, Burtnick LD, Mejillano M, Yin HL, Robinson RC, Choe S.

J Mol Biol. 2002 Dec 6;324(4):691-702.


Global shapes of F-actin depolymerization-competent minimal gelsolins: insight into the role of g2-g3 linker in pH/Ca2+ insensitivity of the first half.

Peddada N, Sagar A, Rathore YS, Choudhary V, Pattnaik UB, Khatri N, Garg R, Ashish.

J Biol Chem. 2013 Sep 27;288(39):28266-82. doi: 10.1074/jbc.M113.463224. Epub 2013 Aug 12.


Structure of the N-terminal half of gelsolin bound to actin: roles in severing, apoptosis and FAF.

Burtnick LD, Urosev D, Irobi E, Narayan K, Robinson RC.

EMBO J. 2004 Jul 21;23(14):2713-22. Epub 2004 Jun 24.


Helix straightening as an activation mechanism in the gelsolin superfamily of actin regulatory proteins.

Wang H, Chumnarnsilpa S, Loonchanta A, Li Q, Kuan YM, Robine S, Larsson M, Mihalek I, Burtnick LD, Robinson RC.

J Biol Chem. 2009 Aug 7;284(32):21265-9. doi: 10.1074/jbc.M109.019760. Epub 2009 Jun 1.


Co-operation of domain-binding and calcium-binding sites in the activation of gelsolin.

Lagarrigue E, Maciver SK, Fattoum A, Benyamin Y, Roustan C.

Eur J Biochem. 2003 May;270(10):2236-43.


The crystal structure of the C-terminus of adseverin reveals the actin-binding interface.

Chumnarnsilpa S, Lee WL, Nag S, Kannan B, Larsson M, Burtnick LD, Robinson RC.

Proc Natl Acad Sci U S A. 2009 Aug 18;106(33):13719-24. doi: 10.1073/pnas.0812383106. Epub 2009 Aug 4.


Global structure changes associated with Ca2+ activation of full-length human plasma gelsolin.

Ashish, Paine MS, Perryman PB, Yang L, Yin HL, Krueger JK.

J Biol Chem. 2007 Aug 31;282(35):25884-92. Epub 2007 Jun 29.


The crystal structure of plasma gelsolin: implications for actin severing, capping, and nucleation.

Burtnick LD, Koepf EK, Grimes J, Jones EY, Stuart DI, McLaughlin PJ, Robinson RC.

Cell. 1997 Aug 22;90(4):661-70.


Calcium-sensitive activity and conformation of Caenorhabditis elegans gelsolin-like protein 1 are altered by mutations in the first gelsolin-like domain.

Liu Z, Kanzawa N, Ono S.

J Biol Chem. 2011 Sep 30;286(39):34051-9. doi: 10.1074/jbc.M111.237404. Epub 2011 Aug 12.


Gelsolin domains 4-6 in active, actin-free conformation identifies sites of regulatory calcium ions.

Kolappan S, Gooch JT, Weeds AG, McLaughlin PJ.

J Mol Biol. 2003 May 23;329(1):85-92.


Gelsolin-Like Domain 3 Plays Vital Roles in Regulating the Activities of the Lily Villin/Gelsolin/Fragmin Superfamily.

Qian D, Nan Q, Yang Y, Li H, Zhou Y, Zhu J, Bai Q, Zhang P, An L, Xiang Y.

PLoS One. 2015 Nov 20;10(11):e0143174. doi: 10.1371/journal.pone.0143174. eCollection 2015 Nov 20.


Activation in isolation: exposure of the actin-binding site in the C-terminal half of gelsolin does not require actin.

Narayan K, Chumnarnsilpa S, Choe H, Irobi E, Urosev D, Lindberg U, Schutt CE, Burtnick LD, Robinson RC.

FEBS Lett. 2003 Sep 25;552(2-3):82-5.


Visual insight into how low pH alone can induce actin-severing ability in gelsolin under calcium-free conditions.

Garg R, Peddada N, Sagar A, Nihalani D, Ashish.

J Biol Chem. 2011 Jun 10;286(23):20387-97. doi: 10.1074/jbc.M111.236943. Epub 2011 Apr 15.


Domain movement in gelsolin: a calcium-activated switch.

Robinson RC, Mejillano M, Le VP, Burtnick LD, Yin HL, Choe S.

Science. 1999 Dec 3;286(5446):1939-42.


Functional dissection and molecular characterization of calcium-sensitive actin-capping and actin-depolymerizing sites in villin.

Kumar N, Tomar A, Parrill AL, Khurana S.

J Biol Chem. 2004 Oct 22;279(43):45036-46. Epub 2004 Jul 21.


Severing of F-actin by the amino-terminal half of gelsolin suggests internal cooperativity in gelsolin.

Selden LA, Kinosian HJ, Newman J, Lincoln B, Hurwitz C, Gershman LC, Estes JE.

Biophys J. 1998 Dec;75(6):3092-100.

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