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Items: 1 to 20 of 387

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2.

Tetrahydrobiopterin recycling, a key determinant of endothelial nitric-oxide synthase-dependent signaling pathways in cultured vascular endothelial cells.

Sugiyama T, Levy BD, Michel T.

J Biol Chem. 2009 May 8;284(19):12691-700. doi: 10.1074/jbc.M809295200. Epub 2009 Mar 12.

3.

Dihydrofolate reductase protects endothelial nitric oxide synthase from uncoupling in tetrahydrobiopterin deficiency.

Crabtree MJ, Hale AB, Channon KM.

Free Radic Biol Med. 2011 Jun 1;50(11):1639-46. doi: 10.1016/j.freeradbiomed.2011.03.010. Epub 2011 Mar 12.

4.

Quantitative regulation of intracellular endothelial nitric-oxide synthase (eNOS) coupling by both tetrahydrobiopterin-eNOS stoichiometry and biopterin redox status: insights from cells with tet-regulated GTP cyclohydrolase I expression.

Crabtree MJ, Tatham AL, Al-Wakeel Y, Warrick N, Hale AB, Cai S, Channon KM, Alp NJ.

J Biol Chem. 2009 Jan 9;284(2):1136-44. doi: 10.1074/jbc.M805403200. Epub 2008 Nov 14.

5.

Cell type-specific recycling of tetrahydrobiopterin by dihydrofolate reductase explains differential effects of 7,8-dihydrobiopterin on endothelial nitric oxide synthase uncoupling.

Schmidt K, Kolesnik B, Gorren AC, Werner ER, Mayer B.

Biochem Pharmacol. 2014 Aug 1;90(3):246-53. doi: 10.1016/j.bcp.2014.05.010. Epub 2014 May 24.

6.

Synthesis and recycling of tetrahydrobiopterin in endothelial function and vascular disease.

Crabtree MJ, Channon KM.

Nitric Oxide. 2011 Aug 1;25(2):81-8. doi: 10.1016/j.niox.2011.04.004. Epub 2011 Apr 22. Review.

7.

Mechanism of reversal of high glucose-induced endothelial nitric oxide synthase uncoupling by tanshinone IIA in human endothelial cell line EA.hy926.

Zhou ZW, Xie XL, Zhou SF, Li CG.

Eur J Pharmacol. 2012 Dec 15;697(1-3):97-105. doi: 10.1016/j.ejphar.2012.09.051. Epub 2012 Oct 11.

PMID:
23063542
8.

Endothelial Nitric Oxide Synthase-Derived Nitric Oxide Prevents Dihydrofolate Reductase Degradation via Promoting S-Nitrosylation.

Cai Z, Lu Q, Ding Y, Wang Q, Xiao L, Song P, Zou MH.

Arterioscler Thromb Vasc Biol. 2015 Nov;35(11):2366-73. doi: 10.1161/ATVBAHA.115.305796. Epub 2015 Sep 17.

9.

Folic Acid Promotes Recycling of Tetrahydrobiopterin and Protects Against Hypoxia-Induced Pulmonary Hypertension by Recoupling Endothelial Nitric Oxide Synthase.

Chalupsky K, Kračun D, Kanchev I, Bertram K, Görlach A.

Antioxid Redox Signal. 2015 Nov 10;23(14):1076-91. doi: 10.1089/ars.2015.6329. Epub 2015 Nov 5.

10.
11.

A pivotal role for tryptophan 447 in enzymatic coupling of human endothelial nitric oxide synthase (eNOS): effects on tetrahydrobiopterin-dependent catalysis and eNOS dimerization.

Benson MA, Batchelor H, Chuaiphichai S, Bailey J, Zhu H, Stuehr DJ, Bhattacharya S, Channon KM, Crabtree MJ.

J Biol Chem. 2013 Oct 11;288(41):29836-45. doi: 10.1074/jbc.M113.493023. Epub 2013 Aug 21.

12.
13.

HMG-CoA reductase inhibitor increases GTP cyclohydrolase I mRNA and tetrahydrobiopterin in vascular endothelial cells.

Hattori Y, Nakanishi N, Akimoto K, Yoshida M, Kasai K.

Arterioscler Thromb Vasc Biol. 2003 Feb 1;23(2):176-82.

14.

A key role for tetrahydrobiopterin-dependent endothelial NOS regulation in resistance arteries: studies in endothelial cell tetrahydrobiopterin-deficient mice.

Chuaiphichai S, Crabtree MJ, Mcneill E, Hale AB, Trelfa L, Channon KM, Douglas G.

Br J Pharmacol. 2017 Apr;174(8):657-671. doi: 10.1111/bph.13728. Epub 2017 Mar 13.

15.

Characterization of cerebral microvasculature in transgenic mice with endothelium targeted over-expression of GTP-cyclohydrolase I.

Santhanam AV, d'Uscio LV, Katusic ZS.

Brain Res. 2015 Nov 2;1625:198-205. doi: 10.1016/j.brainres.2015.08.034. Epub 2015 Sep 3.

16.

Integrated redox sensor and effector functions for tetrahydrobiopterin- and glutathionylation-dependent endothelial nitric-oxide synthase uncoupling.

Crabtree MJ, Brixey R, Batchelor H, Hale AB, Channon KM.

J Biol Chem. 2013 Jan 4;288(1):561-9. doi: 10.1074/jbc.M112.415992. Epub 2012 Nov 8.

17.

Tetrahydrobiopterin-dependent preservation of nitric oxide-mediated endothelial function in diabetes by targeted transgenic GTP-cyclohydrolase I overexpression.

Alp NJ, Mussa S, Khoo J, Cai S, Guzik T, Jefferson A, Goh N, Rockett KA, Channon KM.

J Clin Invest. 2003 Sep;112(5):725-35.

18.

Human endothelial dihydrofolate reductase low activity limits vascular tetrahydrobiopterin recycling.

Whitsett J, Rangel Filho A, Sethumadhavan S, Celinska J, Widlansky M, Vasquez-Vivar J.

Free Radic Biol Med. 2013 Oct;63:143-50. doi: 10.1016/j.freeradbiomed.2013.04.035. Epub 2013 May 23.

19.

Biopterin metabolism and eNOS expression during hypoxic pulmonary hypertension in mice.

Dubois M, Delannoy E, Duluc L, Closs E, Li H, Toussaint C, Gadeau AP, Gödecke A, Freund-Michel V, Courtois A, Marthan R, Savineau JP, Muller B.

PLoS One. 2013 Nov 27;8(11):e82594. doi: 10.1371/journal.pone.0082594. eCollection 2013.

20.

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