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19660276,2023435,15052202,17140947,19716708,8412262,2709864,12658205,16580438,1434722,19624364,11174740,17505416,17000293,15519182,15052200,16996957,16857368,15857532,14992914,19185170,10838546,19559218,9386115,12354717,17382626,12698148,6708579,11119081,9386124,18374779,16515920,12658188,19324918,2329827,2766529,20117805,11326236,19758609,18282396,19682949,17140952,8901720,6201681,2072731,19481468,8893558,17138087,16077400,14752434,15200982,17289482,24561569,15071863,1820016,21531569,19640727,15999044,7715223,1657453,15793727,15111160,27604310,16214523,16798203,17976454,8263052,11761090,22306226,8159021,8523875,14752407,21092040,9288512,33485668,17000295,17000309,8138683,16762873,11994867,19853102,3336226,22581033,18404056,18374757,16798306,11981706,1186284,15680853,9852920,19683993,19054693,23499473,8633939,19169989,22611025,16456447,15103580,1597978,17126140,20473147,8947952,11326240,1208992,8551760,8873735,10534701,3784587,15362203,16504530,12587092,16733167,16077389,24698562,8800158,16427835,10788825,17644341,17720373,15951193,2493109,15464507,19383589,15173730,15282456,8371727,17532961,9170859,22747795,17537332,15919416,11088037,17205010,9667301,18035930,16153911,18043140,15172283,2117099,2682024,17307429,17307459,18577891,17126136,18290884,8321003,19411260,16081199,7838188,9356234,16095460,23998412,19914925,14697105,28132587,15797070,16844626,22306220,23138358,16723048,33947997,9366581,19740304,18292411,19713338,24206193,11968717,21095348,12470399,7717685,23141032,9338645,17382619,15621474,16476186,21790676,7780080,15223426,16733166,17258589,18207624,15975375,7989789,15108786,11189232,12768122,19203824,15334752,4058045,16458205,7739258,19328618,8975853,1545553,15173737,1157233,8028354,462466,10649206,2232388,19188077,27174550,17126142,11479507,17198777,15282458,26333187,12646718,2008099,6606086,10789566,10421107,7475159,11689791,19690267,21425052,11253898,19240742,15753756,20176202,16966864,10343269,18840584,8678629,15062042,8267469,18329512,8494416,15706992,2020517,18243007,7518665,2381001,10917961,11479508,10917938,8417712,8176965,2359320,18043147,8076019,16376567,19136750,20663677,20601925,10343273,29272381,28622752,27765895,3512920,19133031,19406658,16053944,1960423,15111162,18325141,11994868,10369646,24709187,14530576,19651068,16904984,18583292,17331738,15116005,12453696,9360089,23266253,9605074,18658167,17720388,17320569,16828301,8267473,9416284,19489244,7586460,7609569,8512392,3119800,2516526,16844627,16879469,11922502,14583315,16824241,17481798,17532957,18721563,9305198,1405671,712129,17658556,19713341,8638782,17198097,12658213,15019667,19327511,10950382,18304123,3669700,17723803,17460516,16266300,32236538,17588406,7934099,8604918,15083340,9731793,11807400,9104988,20233898,11986601,16181887,22011772,10667516,8023360,19770397,27592601,14530015,16427864,18656301,16368360,11994869,10499900,11986591,10148570,1449298,19217795,22205016,22288607,31119151,9671911,15111164,10917937,33355066,8267477,18431278,9806385,19463592,2502690,16023395,18365970,10439741,23478660,15302054,7887706,15818352,17383394,17336082,26254749,11568066,19443495,18043143,21933819,17000307,29331552,8279927,12019380,3664911,11093473,20647245,15223717,11098950,15144646,19181758,10463495,18579398,11174743,15084194,18222275,18032058,14605536,16755447,2795843,8028355,31005300,19114919,8300712,37607,9456110,9852931,11460991,31211648,9883756,23305585,8678642,119053,18695551,7733761,10758389,16077403,9146309,16146461,8634390,14979426,18640309,17382224,11837244,17159672,32408343,32240645,26581834,84096,11951061,10078703,17670490,19193518,7579835,1417216,24343749,8379725,7739254,24110060,8402184,12406143,15283362,17257930,29346537,19092651,10147642,16651308,23734286,10560148,36537725,11907394,8127107,26265692,22711715,3954495,7887693,28719038,29580655,15975331,19282752,15797068,24045074,21397270,18396225,26960374,34156120,16488691,3800020,20442040,1416162,8267470,18983644,16243986,15073707,1207269,16597482,3209899,22843513,19521295,7856909,30121135,27734011,17983955,8523881,6617249,32817746,25082120,20723733,20566208,25131168,12062294,17669980,17923576,15854340,16256773,1961404,20478954,7733705,19567545,17484169,11953122,21705904,15208966,17911080,9778014,2035855,617441,33454045,26007621,16242503,22498087,10391334,10073769,9628370,11761094,11419652,11692584,10343268,8250531,17071098,11159225,23977575,19318271,12537216,16629653,6009306,18207625,12428335,16731160,25717255,2039323,32090681,35431978,20150046,1152495,21549269,19660347,10639046,19077632,11221730,17954200,9636904,17040301,16458220,14531254,11604345,15808626,7598581,14992743,32009532,17023288,26405357,31129071,12165879,19428525,27585201,28478907,18721617,3046027,18249359,16083612,1962333,34182499,18640761,14762364,16515913,18334888,12853056,7994097,23540655,36779673,21859790,26901125,21095349,17852788,30071237,11727909,3373713,18292407,7410912,17185186,18786945,14689421,7696741,7604425,8267474,1928775,21111715,12656550,17936003,11156352,17890801,16836736,16037141,19242339,108265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Page 1

Effects of moderate versus deep hypothermic circulatory arrest and selective cerebral perfusion on cerebrospinal fluid proteomic profiles in a piglet model of cardiopulmonary bypass.

Allibhai T, DiGeronimo R, Whitin J, Salazar J, Yu TT, Ling XB, Cohen H, Dixon P, Madan A. Allibhai T, et al. J Thorac Cardiovasc Surg. 2009 Dec;138(6):1290-6. doi: 10.1016/j.jtcvs.2009.06.001. Epub 2009 Jul 29. J Thorac Cardiovasc Surg. 2009. PMID: 19660276 Free article.

The effect of hypothermic cardiopulmonary bypass and total circulatory arrest on cerebral metabolism in neonates, infants, and children.

Greeley WJ, Kern FH, Ungerleider RM, Boyd JL 3rd, Quill T, Smith LR, Baldwin B, Reves JG. Greeley WJ, et al. J Thorac Cardiovasc Surg. 1991 May;101(5):783-94. J Thorac Cardiovasc Surg. 1991. PMID: 2023435

Regional low-flow perfusion improves neurologic outcome compared with deep hypothermic circulatory arrest in neonatal piglets.

Myung RJ, Petko M, Judkins AR, Schears G, Ittenbach RF, Waibel RJ, DeCampli WM. Myung RJ, et al. J Thorac Cardiovasc Surg. 2004 Apr;127(4):1051-6; discussion 1056-7. doi: 10.1016/j.jtcvs.2003.11.008. J Thorac Cardiovasc Surg. 2004. PMID: 15052202 Free article.

Visual light spectroscopy reflects flow-related changes in brain oxygenation during regional low-flow perfusion and deep hypothermic circulatory arrest.

Amir G, Ramamoorthy C, Riemer RK, Davis CR, Hanley FL, Reddy VM. Amir G, et al. J Thorac Cardiovasc Surg. 2006 Dec;132(6):1307-13. doi: 10.1016/j.jtcvs.2006.04.056. Epub 2006 Nov 16. J Thorac Cardiovasc Surg. 2006. PMID: 17140947 Free article.

Hypothermic extracorporeal circulation in immature swine: a comparison of continuous cardiopulmonary bypass, selective antegrade cerebral perfusion and circulatory arrest.

Sasaki H, Guleserian KJ, Rose R, Fotiadis C, Boyer PJ, Forbess JM. Sasaki H, et al. Eur J Cardiothorac Surg. 2009 Dec;36(6):992-7. doi: 10.1016/j.ejcts.2009.05.029. Epub 2009 Aug 28. Eur J Cardiothorac Surg. 2009. PMID: 19716708

Recovery of cerebral blood flow and energy state in piglets after hypothermic circulatory arrest versus recovery after low-flow bypass.

Kawata H, Fackler JC, Aoki M, Tsuji MK, Sawatari K, Offutt M, Hickey PR, Holtzman D, Jonas RA. Kawata H, et al. J Thorac Cardiovasc Surg. 1993 Oct;106(4):671-85. J Thorac Cardiovasc Surg. 1993. PMID: 8412262

The effects of deep hypothermic cardiopulmonary bypass and total circulatory arrest on cerebral blood flow in infants and children.

Greeley WJ, Ungerleider RM, Smith LR, Reves JG. Greeley WJ, et al. J Thorac Cardiovasc Surg. 1989 May;97(5):737-45. J Thorac Cardiovasc Surg. 1989. PMID: 2709864

Deep hypothermic circulatory arrest and global reperfusion injury: avoidance by making a pump prime reperfusate--a new concept.

Allen BS, Veluz JS, Buckberg GD, Aeberhard E, Ignarro LJ. Allen BS, et al. J Thorac Cardiovasc Surg. 2003 Mar;125(3):625-32. doi: 10.1067/mtc.2003.96. J Thorac Cardiovasc Surg. 2003. PMID: 12658205 Free article.

Neurologic outcome after cardiopulmonary bypass with deep hypothermic circulatory arrest in rats: description of a new model.

Jungwirth B, Mackensen GB, Blobner M, Neff F, Reichart B, Kochs EF, Nollert G. Jungwirth B, et al. J Thorac Cardiovasc Surg. 2006 Apr;131(4):805-12. doi: 10.1016/j.jtcvs.2005.11.017. J Thorac Cardiovasc Surg. 2006. PMID: 16580438 Free article.

A comparison of the effects on neuronal Golgi morphology, assessed with electron microscopy, of cardiopulmonary bypass, low-flow bypass, and circulatory arrest during profound hypothermia.

Scheller MS, Branson PJ, Cornacchia LG, Alksne JF. Scheller MS, et al. J Thorac Cardiovasc Surg. 1992 Nov;104(5):1396-404. J Thorac Cardiovasc Surg. 1992. PMID: 1434722

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