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Endotoxin tolerance dysregulates MyD88- and Toll/IL-1R domain-containing adapter inducing IFN-beta-dependent pathways and increases expression of negative regulators of TLR signaling.

Piao W, Song C, Chen H, Diaz MA, Wahl LM, Fitzgerald KA, Li L, Medvedev AE.

J Leukoc Biol. 2009 Oct;86(4):863-75. doi: 10.1189/jlb.0309189. Epub 2009 Aug 5.


Pellino-1 Positively Regulates Toll-like Receptor (TLR) 2 and TLR4 Signaling and Is Suppressed upon Induction of Endotoxin Tolerance.

Murphy M, Xiong Y, Pattabiraman G, Qiu F, Medvedev AE.

J Biol Chem. 2015 Jul 31;290(31):19218-32. doi: 10.1074/jbc.M115.640128. Epub 2015 Jun 16.


The Asp299Gly polymorphism alters TLR4 signaling by interfering with recruitment of MyD88 and TRIF.

Figueroa L, Xiong Y, Song C, Piao W, Vogel SN, Medvedev AE.

J Immunol. 2012 May 1;188(9):4506-15. doi: 10.4049/jimmunol.1200202. Epub 2012 Apr 2.


SOCS1 regulates the IFN but not NFkappaB pathway in TLR-stimulated human monocytes and macrophages.

PrĂȘle CM, Woodward EA, Bisley J, Keith-Magee A, Nicholson SE, Hart PH.

J Immunol. 2008 Dec 1;181(11):8018-26.


CD14 dependence of TLR4 endocytosis and TRIF signaling displays ligand specificity and is dissociable in endotoxin tolerance.

Rajaiah R, Perkins DJ, Ireland DD, Vogel SN.

Proc Natl Acad Sci U S A. 2015 Jul 7;112(27):8391-6. doi: 10.1073/pnas.1424980112. Epub 2015 Jun 23.


Role of TLR4 tyrosine phosphorylation in signal transduction and endotoxin tolerance.

Medvedev AE, Piao W, Shoenfelt J, Rhee SH, Chen H, Basu S, Wahl LM, Fenton MJ, Vogel SN.

J Biol Chem. 2007 Jun 1;282(22):16042-53. Epub 2007 Mar 28.


Melatonin modulates TLR4-mediated inflammatory genes through MyD88- and TRIF-dependent signaling pathways in lipopolysaccharide-stimulated RAW264.7 cells.

Xia MZ, Liang YL, Wang H, Chen X, Huang YY, Zhang ZH, Chen YH, Zhang C, Zhao M, Xu DX, Song LH.

J Pineal Res. 2012 Nov;53(4):325-34. doi: 10.1111/j.1600-079X.2012.01002.x. Epub 2012 Apr 27.


Pellino-3 promotes endotoxin tolerance and acts as a negative regulator of TLR2 and TLR4 signaling.

Murphy MB, Xiong Y, Pattabiraman G, Manavalan TT, Qiu F, Medvedev AE.

J Leukoc Biol. 2015 Dec;98(6):963-74. doi: 10.1189/jlb.2VMA0515-229RR. Epub 2015 Aug 26.


SARM inhibits both TRIF- and MyD88-mediated AP-1 activation.

Peng J, Yuan Q, Lin B, Panneerselvam P, Wang X, Luan XL, Lim SK, Leung BP, Ho B, Ding JL.

Eur J Immunol. 2010 Jun;40(6):1738-47. doi: 10.1002/eji.200940034.


Role for MyD88-independent, TRIF pathway in lipid A/TLR4-induced endotoxin tolerance.

Biswas SK, Bist P, Dhillon MK, Kajiji T, Del Fresno C, Yamamoto M, Lopez-Collazo E, Akira S, Tergaonkar V.

J Immunol. 2007 Sep 15;179(6):4083-92.


Anesthetic agent propofol inhibits myeloid differentiation factor 88-dependent and independent signaling and mitigates lipopolysaccharide-mediated reactive oxygen species production in human neutrophils in vitro.

Ren X, Lv F, Fang B, Liu S, Lv H, He G, Ma H, Cao Y, Wang Y.

Eur J Pharmacol. 2014 Dec 5;744:164-72. doi: 10.1016/j.ejphar.2014.10.030. Epub 2014 Oct 28.


Dominant role of the MyD88-dependent signaling pathway in mediating early endotoxin-induced murine ileus.

Buchholz BM, Billiar TR, Bauer AJ.

Am J Physiol Gastrointest Liver Physiol. 2010 Aug;299(2):G531-8. doi: 10.1152/ajpgi.00060.2010. Epub 2010 May 27.


TRIF signaling is essential for TLR4-driven IgE class switching.

Janssen E, Ozcan E, Liadaki K, Jabara HH, Manis J, Ullas S, Akira S, Fitzgerald KA, Golenbock DT, Geha RS.

J Immunol. 2014 Mar 15;192(6):2651-8. doi: 10.4049/jimmunol.1300909. Epub 2014 Feb 14.


Cutting edge: a novel Toll/IL-1 receptor domain-containing adapter that preferentially activates the IFN-beta promoter in the Toll-like receptor signaling.

Yamamoto M, Sato S, Mori K, Hoshino K, Takeuchi O, Takeda K, Akira S.

J Immunol. 2002 Dec 15;169(12):6668-72.


TRIF-mediated TLR3 and TLR4 signaling is negatively regulated by ADAM15.

Ahmed S, Maratha A, Butt AQ, Shevlin E, Miggin SM.

J Immunol. 2013 Mar 1;190(5):2217-28. doi: 10.4049/jimmunol.1201630. Epub 2013 Jan 30.


SARM modulates MyD88-mediated TLR activation through BB-loop dependent TIR-TIR interactions.

Carlsson E, Ding JL, Byrne B.

Biochim Biophys Acta. 2016 Feb;1863(2):244-53. doi: 10.1016/j.bbamcr.2015.11.021. Epub 2015 Nov 22.

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