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Hsp90 governs echinocandin resistance in the pathogenic yeast Candida albicans via calcineurin.

Singh SD, Robbins N, Zaas AK, Schell WA, Perfect JR, Cowen LE.

PLoS Pathog. 2009 Jul;5(7):e1000532. doi: 10.1371/journal.ppat.1000532. Epub 2009 Jul 31.


PKC signaling regulates drug resistance of the fungal pathogen Candida albicans via circuitry comprised of Mkc1, calcineurin, and Hsp90.

LaFayette SL, Collins C, Zaas AK, Schell WA, Betancourt-Quiroz M, Gunatilaka AA, Perfect JR, Cowen LE.

PLoS Pathog. 2010 Aug 26;6(8):e1001069. doi: 10.1371/journal.ppat.1001069.


Hsp90 governs dispersion and drug resistance of fungal biofilms.

Robbins N, Uppuluri P, Nett J, Rajendran R, Ramage G, Lopez-Ribot JL, Andes D, Cowen LE.

PLoS Pathog. 2011 Sep;7(9):e1002257. doi: 10.1371/journal.ppat.1002257. Epub 2011 Sep 8.


The Hsp90 co-chaperone Sgt1 governs Candida albicans morphogenesis and drug resistance.

Shapiro RS, Zaas AK, Betancourt-Quiroz M, Perfect JR, Cowen LE.

PLoS One. 2012;7(9):e44734. doi: 10.1371/journal.pone.0044734. Epub 2012 Sep 6.


Global analysis of the evolution and mechanism of echinocandin resistance in Candida glabrata.

Singh-Babak SD, Babak T, Diezmann S, Hill JA, Xie JL, Chen YL, Poutanen SM, Rennie RP, Heitman J, Cowen LE.

PLoS Pathog. 2012;8(5):e1002718. doi: 10.1371/journal.ppat.1002718. Epub 2012 May 17.


Genetic and genomic architecture of the evolution of resistance to antifungal drug combinations.

Hill JA, Ammar R, Torti D, Nislow C, Cowen LE.

PLoS Genet. 2013 Apr;9(4):e1003390. doi: 10.1371/journal.pgen.1003390. Epub 2013 Apr 4.


In vitro study of sequential fluconazole and caspofungin treatment against Candida albicans biofilms.

Sarkar S, Uppuluri P, Pierce CG, Lopez-Ribot JL.

Antimicrob Agents Chemother. 2014;58(2):1183-6. doi: 10.1128/AAC.01745-13. Epub 2013 Nov 11.


Harnessing Hsp90 function as a powerful, broadly effective therapeutic strategy for fungal infectious disease.

Cowen LE, Singh SD, Köhler JR, Collins C, Zaas AK, Schell WA, Aziz H, Mylonakis E, Perfect JR, Whitesell L, Lindquist S.

Proc Natl Acad Sci U S A. 2009 Feb 24;106(8):2818-23. doi: 10.1073/pnas.0813394106. Epub 2009 Feb 5.


Calcineurin is required for pseudohyphal growth, virulence, and drug resistance in Candida lusitaniae.

Zhang J, Silao FG, Bigol UG, Bungay AA, Nicolas MG, Heitman J, Chen YL.

PLoS One. 2012;7(8):e44192. doi: 10.1371/journal.pone.0044192. Epub 2012 Aug 31.


Heat shock protein 90 is required for conidiation and cell wall integrity in Aspergillus fumigatus.

Lamoth F, Juvvadi PR, Fortwendel JR, Steinbach WJ.

Eukaryot Cell. 2012 Nov;11(11):1324-32. doi: 10.1128/EC.00032-12. Epub 2012 Jul 20.


Calcineurin controls hyphal growth, virulence, and drug tolerance of Candida tropicalis.

Chen YL, Yu SJ, Huang HY, Chang YL, Lehman VN, Silao FG, Bigol UG, Bungay AA, Averette A, Heitman J.

Eukaryot Cell. 2014 Jul;13(7):844-54. doi: 10.1128/EC.00302-13. Epub 2014 Jan 17.


Calcineurin controls drug tolerance, hyphal growth, and virulence in Candida dubliniensis.

Chen YL, Brand A, Morrison EL, Silao FG, Bigol UG, Malbas FF Jr, Nett JE, Andes DR, Solis NV, Filler SG, Averette A, Heitman J.

Eukaryot Cell. 2011 Jun;10(6):803-19. doi: 10.1128/EC.00310-10. Epub 2011 Apr 29.


Hsp90 orchestrates temperature-dependent Candida albicans morphogenesis via Ras1-PKA signaling.

Shapiro RS, Uppuluri P, Zaas AK, Collins C, Senn H, Perfect JR, Heitman J, Cowen LE.

Curr Biol. 2009 Apr 28;19(8):621-9. doi: 10.1016/j.cub.2009.03.017. Epub 2009 Mar 26.


Lysine deacetylases Hda1 and Rpd3 regulate Hsp90 function thereby governing fungal drug resistance.

Robbins N, Leach MD, Cowen LE.

Cell Rep. 2012 Oct 25;2(4):878-88. doi: 10.1016/j.celrep.2012.08.035. Epub 2012 Oct 4.


Identification of a key lysine residue in heat shock protein 90 required for azole and echinocandin resistance in Aspergillus fumigatus.

Lamoth F, Juvvadi PR, Soderblom EJ, Moseley MA, Asfaw YG, Steinbach WJ.

Antimicrob Agents Chemother. 2014;58(4):1889-96. doi: 10.1128/AAC.02286-13. Epub 2014 Jan 6.


Hsp90 potentiates the rapid evolution of new traits: drug resistance in diverse fungi.

Cowen LE, Lindquist S.

Science. 2005 Sep 30;309(5744):2185-9.


Echinocandin resistance in human pathogenic fungi.

Munro CA.

Expert Rev Anti Infect Ther. 2012 Feb;10(2):115-6. doi: 10.1586/eri.11.171. No abstract available.


Hsp90 is involved in apoptosis of Candida albicans by regulating the calcineurin-caspase apoptotic pathway.

Dai B, Wang Y, Li D, Xu Y, Liang R, Zhao L, Cao Y, Jia J, Jiang Y.

PLoS One. 2012;7(9):e45109. doi: 10.1371/journal.pone.0045109. Epub 2012 Sep 18.


Hsp90 orchestrates stress response signaling governing fungal drug resistance.

Cowen LE.

PLoS Pathog. 2009 Aug;5(8):e1000471. doi: 10.1371/journal.ppat.1000471. Epub 2009 Aug 28. No abstract available.


Metabolic control of antifungal drug resistance.

Robbins N, Collins C, Morhayim J, Cowen LE.

Fungal Genet Biol. 2010 Feb;47(2):81-93. doi: 10.1016/j.fgb.2009.07.004. Epub 2009 Jul 10.


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