Similar articles for PMID: 19640844

Year	Number of Results
2002	1
2004	2
2005	5
2006	4
2007	4
2008	9
2009	7
2010	7
2011	15
2012	11
2013	10
2014	14
2015	7
2016	14
2017	8
2018	12
2019	10
2020	13
2021	13
2022	6
2024	0

1

Structural plasticity of malaria dihydroorotate dehydrogenase allows selective binding of diverse chemical scaffolds.

Deng X, Gujjar R, El Mazouni F, Kaminsky W, Malmquist NA, Goldsmith EJ, Rathod PK, Phillips MA. Deng X, et al. J Biol Chem. 2009 Sep 25;284(39):26999-7009. doi: 10.1074/jbc.M109.028589. Epub 2009 Jul 28. J Biol Chem. 2009. PMID: 19640844 Free PMC article.

2

In vitro resistance selections for Plasmodium falciparum dihydroorotate dehydrogenase inhibitors give mutants with multiple point mutations in the drug-binding site and altered growth.

Ross LS, Gamo FJ, Lafuente-Monasterio MJ, Singh OM, Rowland P, Wiegand RC, Wirth DF. Ross LS, et al. J Biol Chem. 2014 Jun 27;289(26):17980-95. doi: 10.1074/jbc.M114.558353. Epub 2014 Apr 29. J Biol Chem. 2014. PMID: 24782313 Free PMC article.

3

Fluorine modulates species selectivity in the triazolopyrimidine class of Plasmodium falciparum dihydroorotate dehydrogenase inhibitors.

Deng X, Kokkonda S, El Mazouni F, White J, Burrows JN, Kaminsky W, Charman SA, Matthews D, Rathod PK, Phillips MA. Deng X, et al. J Med Chem. 2014 Jun 26;57(12):5381-94. doi: 10.1021/jm500481t. Epub 2014 Jun 13. J Med Chem. 2014. PMID: 24801997 Free PMC article.

4

Understanding the structural requirements in diverse scaffolds for the inhibition of P. falciparum dihydroorotate dehydrogenase (PfDHODH) using 2D-QSAR, 3D-pharmacophore and structure-based energy- optimized pharmacophore models.

Aher RB, Roy K. Aher RB, et al. Comb Chem High Throughput Screen. 2015;18(2):217-26. doi: 10.2174/1386207318666141229124503. Comb Chem High Throughput Screen. 2015. PMID: 25543684

5

Identification of 3,4-Dihydro-2H,6H-pyrimido[1,2-c][1,3]benzothiazin-6-imine Derivatives as Novel Selective Inhibitors of Plasmodium falciparum Dihydroorotate Dehydrogenase.

Hartuti ED, Sakura T, Tagod MSO, Yoshida E, Wang X, Mochizuki K, Acharjee R, Matsuo Y, Tokumasu F, Mori M, Waluyo D, Shiomi K, Nozaki T, Hamano S, Shiba T, Kita K, Inaoka DK. Hartuti ED, et al. Int J Mol Sci. 2021 Jul 5;22(13):7236. doi: 10.3390/ijms22137236. Int J Mol Sci. 2021. PMID: 34281290 Free PMC article.

6

A Triazolopyrimidine-Based Dihydroorotate Dehydrogenase Inhibitor with Improved Drug-like Properties for Treatment and Prevention of Malaria.

Phillips MA, White KL, Kokkonda S, Deng X, White J, El Mazouni F, Marsh K, Tomchick DR, Manjalanagara K, Rudra KR, Wirjanata G, Noviyanti R, Price RN, Marfurt J, Shackleford DM, Chiu FC, Campbell M, Jimenez-Diaz MB, Bazaga SF, Angulo-Barturen I, Martinez MS, Lafuente-Monasterio M, Kaminsky W, Silue K, Zeeman AM, Kocken C, Leroy D, Blasco B, Rossignol E, Rueckle T, Matthews D, Burrows JN, Waterson D, Palmer MJ, Rathod PK, Charman SA. Phillips MA, et al. ACS Infect Dis. 2016 Dec 9;2(12):945-957. doi: 10.1021/acsinfecdis.6b00144. Epub 2016 Oct 4. ACS Infect Dis. 2016. PMID: 27641613 Free PMC article.

7

Hydroxyazole scaffold-based Plasmodium falciparum dihydroorotate dehydrogenase inhibitors: Synthesis, biological evaluation and X-ray structural studies.

Pippione AC, Sainas S, Goyal P, Fritzson I, Cassiano GC, Giraudo A, Giorgis M, Tavella TA, Bagnati R, Rolando B, Caing-Carlsson R, Costa FTM, Andrade CH, Al-Karadaghi S, Boschi D, Friemann R, Lolli ML. Pippione AC, et al. Eur J Med Chem. 2019 Feb 1;163:266-280. doi: 10.1016/j.ejmech.2018.11.044. Epub 2018 Nov 22. Eur J Med Chem. 2019. PMID: 30529545 Free article.

8

Triazolopyrimidine-based dihydroorotate dehydrogenase inhibitors with potent and selective activity against the malaria parasite Plasmodium falciparum.

Phillips MA, Gujjar R, Malmquist NA, White J, El Mazouni F, Baldwin J, Rathod PK. Phillips MA, et al. J Med Chem. 2008 Jun 26;51(12):3649-53. doi: 10.1021/jm8001026. Epub 2008 Jun 4. J Med Chem. 2008. PMID: 18522386 Free PMC article.

9

Identification of a metabolically stable triazolopyrimidine-based dihydroorotate dehydrogenase inhibitor with antimalarial activity in mice.

Gujjar R, Marwaha A, El Mazouni F, White J, White KL, Creason S, Shackleford DM, Baldwin J, Charman WN, Buckner FS, Charman S, Rathod PK, Phillips MA. Gujjar R, et al. J Med Chem. 2009 Apr 9;52(7):1864-72. doi: 10.1021/jm801343r. J Med Chem. 2009. PMID: 19296651 Free PMC article.

10

Novel selective and potent inhibitors of malaria parasite dihydroorotate dehydrogenase: discovery and optimization of dihydrothiophenone derivatives.

Xu M, Zhu J, Diao Y, Zhou H, Ren X, Sun D, Huang J, Han D, Zhao Z, Zhu L, Xu Y, Li H. Xu M, et al. J Med Chem. 2013 Oct 24;56(20):7911-24. doi: 10.1021/jm400938g. Epub 2013 Oct 11. J Med Chem. 2013. PMID: 24073986

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