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Through the looking glass, mechanistic insights from enantiomeric human defensins.

Wei G, de Leeuw E, Pazgier M, Yuan W, Zou G, Wang J, Ericksen B, Lu WY, Lehrer RI, Lu W.

J Biol Chem. 2009 Oct 16;284(42):29180-92. doi: 10.1074/jbc.M109.018085. Epub 2009 Jul 29.


Functional determinants of human enteric α-defensin HD5: crucial role for hydrophobicity at dimer interface.

Rajabi M, Ericksen B, Wu X, de Leeuw E, Zhao L, Pazgier M, Lu W.

J Biol Chem. 2012 Jun 22;287(26):21615-27. doi: 10.1074/jbc.M112.367995. Epub 2012 May 9.


Sometimes it takes two to tango: contributions of dimerization to functions of human α-defensin HNP1 peptide.

Pazgier M, Wei G, Ericksen B, Jung G, Wu Z, de Leeuw E, Yuan W, Szmacinski H, Lu WY, Lubkowski J, Lehrer RI, Lu W.

J Biol Chem. 2012 Mar 16;287(12):8944-53. doi: 10.1074/jbc.M111.332205. Epub 2012 Jan 23.


Single, double and quadruple alanine substitutions at oligomeric interfaces identify hydrophobicity as the key determinant of human neutrophil alpha defensin HNP1 function.

Zhao L, Tolbert WD, Ericksen B, Zhan C, Wu X, Yuan W, Li X, Pazgier M, Lu W.

PLoS One. 2013 Nov 13;8(11):e78937. doi: 10.1371/journal.pone.0078937. eCollection 2013.


Trp-26 imparts functional versatility to human alpha-defensin HNP1.

Wei G, Pazgier M, de Leeuw E, Rajabi M, Li J, Zou G, Jung G, Yuan W, Lu WY, Lehrer RI, Lu W.

J Biol Chem. 2010 May 21;285(21):16275-85. doi: 10.1074/jbc.M110.102749. Epub 2010 Mar 10.


Antibacterial activity and specificity of the six human {alpha}-defensins.

Ericksen B, Wu Z, Lu W, Lehrer RI.

Antimicrob Agents Chemother. 2005 Jan;49(1):269-75.


Invariant gly residue is important for α-defensin folding, dimerization, and function: a case study of the human neutrophil α-defensin HNP1.

Zhao L, Ericksen B, Wu X, Zhan C, Yuan W, Li X, Pazgier M, Lu W.

J Biol Chem. 2012 Jun 1;287(23):18900-12. doi: 10.1074/jbc.M112.355255. Epub 2012 Apr 11.


Variations in the interaction of human defensins with Escherichia coli: Possible implications in bacterial killing.

Mathew B, Nagaraj R.

PLoS One. 2017 Apr 19;12(4):e0175858. doi: 10.1371/journal.pone.0175858. eCollection 2017.


Crystal structures of human alpha-defensins HNP4, HD5, and HD6.

Szyk A, Wu Z, Tucker K, Yang D, Lu W, Lubkowski J.

Protein Sci. 2006 Dec;15(12):2749-60. Epub 2006 Nov 6.


Delineation of interfaces on human alpha-defensins critical for human adenovirus and human papillomavirus inhibition.

Tenge VR, Gounder AP, Wiens ME, Lu W, Smith JG.

PLoS Pathog. 2014 Sep 4;10(9):e1004360. doi: 10.1371/journal.ppat.1004360. eCollection 2014 Sep.


Human alpha- and beta-defensins block multiple steps in herpes simplex virus infection.

Hazrati E, Galen B, Lu W, Wang W, Ouyang Y, Keller MJ, Lehrer RI, Herold BC.

J Immunol. 2006 Dec 15;177(12):8658-66.


Toward understanding the cationicity of defensins. Arg and Lys versus their noncoded analogs.

Zou G, de Leeuw E, Li C, Pazgier M, Li C, Zeng P, Lu WY, Lubkowski J, Lu W.

J Biol Chem. 2007 Jul 6;282(27):19653-65. Epub 2007 Apr 23.


Why is the Arg5-Glu13 salt bridge conserved in mammalian alpha-defensins?

Wu Z, Li X, de Leeuw E, Ericksen B, Lu W.

J Biol Chem. 2005 Dec 30;280(52):43039-47. Epub 2005 Oct 24.


Impact of pro segments on the folding and function of human neutrophil alpha-defensins.

Wu Z, Li X, Ericksen B, de Leeuw E, Zou G, Zeng P, Xie C, Li C, Lubkowski J, Lu WY, Lu W.

J Mol Biol. 2007 Apr 27;368(2):537-49. Epub 2007 Feb 22.


Reconstruction of the conserved beta-bulge in mammalian defensins using D-amino acids.

Xie C, Prahl A, Ericksen B, Wu Z, Zeng P, Li X, Lu WY, Lubkowski J, Lu W.

J Biol Chem. 2005 Sep 23;280(38):32921-9. Epub 2005 May 13.


Retrocyclins kill bacilli and germinating spores of Bacillus anthracis and inactivate anthrax lethal toxin.

Wang W, Mulakala C, Ward SC, Jung G, Luong H, Pham D, Waring AJ, Kaznessis Y, Lu W, Bradley KA, Lehrer RI.

J Biol Chem. 2006 Oct 27;281(43):32755-64. Epub 2006 Jun 21.


Human neutrophil alpha-defensin 4 inhibits HIV-1 infection in vitro.

Wu Z, Cocchi F, Gentles D, Ericksen B, Lubkowski J, Devico A, Lehrer RI, Lu W.

FEBS Lett. 2005 Jan 3;579(1):162-6.


The conserved salt bridge in human alpha-defensin 5 is required for its precursor processing and proteolytic stability.

Rajabi M, de Leeuw E, Pazgier M, Li J, Lubkowski J, Lu W.

J Biol Chem. 2008 Aug 1;283(31):21509-18. doi: 10.1074/jbc.M801851200. Epub 2008 May 22.


Human α-defensins are immune-related Kv1.3 channel inhibitors: new support for their roles in adaptive immunity.

Xie Z, Feng J, Yang W, Xiang F, Yang F, Zhao Y, Cao Z, Li W, Chen Z, Wu Y.

FASEB J. 2015 Oct;29(10):4324-33. doi: 10.1096/fj.15-274787. Epub 2015 Jul 6.


Distinct defensin profiles in Neisseria gonorrhoeae and Chlamydia trachomatis urethritis reveal novel epithelial cell-neutrophil interactions.

Porter E, Yang H, Yavagal S, Preza GC, Murillo O, Lima H, Greene S, Mahoozi L, Klein-Patel M, Diamond G, Gulati S, Ganz T, Rice PA, Quayle AJ.

Infect Immun. 2005 Aug;73(8):4823-33.

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