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Papillary thyroid cancer, although strongly associated with lymphocytic infiltration on histology, is only weakly predicted by serum thyroid auto-antibodies in patients with nodular thyroid diseases.

Fiore E, Rago T, Scutari M, Ugolini C, Proietti A, Di Coscio G, Provenzale MA, Berti P, Grasso L, Mariotti S, Pinchera A, Vitti P.

J Endocrinol Invest. 2009 Apr;32(4):344-51.


Lower levels of TSH are associated with a lower risk of papillary thyroid cancer in patients with thyroid nodular disease: thyroid autonomy may play a protective role.

Fiore E, Rago T, Provenzale MA, Scutari M, Ugolini C, Basolo F, Di Coscio G, Berti P, Grasso L, Elisei R, Pinchera A, Vitti P.

Endocr Relat Cancer. 2009 Dec;16(4):1251-60. doi: 10.1677/ERC-09-0036. Epub 2009 Jun 15.


Male sex, single nodularity, and young age are associated with the risk of finding a papillary thyroid cancer on fine-needle aspiration cytology in a large series of patients with nodular thyroid disease.

Rago T, Fiore E, Scutari M, Santini F, Di Coscio G, Romani R, Piaggi P, Ugolini C, Basolo F, Miccoli P, Pinchera A, Vitti P.

Eur J Endocrinol. 2010 Apr;162(4):763-70. doi: 10.1530/EJE-09-0895. Epub 2010 Jan 18.


Coexistence of thyroglobulin antibodies and thyroid peroxidase antibodies correlates with elevated thyroid-stimulating hormone level and advanced tumor stage of papillary thyroid cancer.

Wu X, Lun Y, Jiang H, Gang Q, Xin S, Duan Z, Zhang J.

Endocrine. 2014 Aug;46(3):554-60. doi: 10.1007/s12020-013-0121-x. Epub 2013 Dec 14.


Clinical features of thyroid autoimmunity are associated with thyroiditis on histology and are not predictive of malignancy in 570 patients with indeterminate nodules on cytology who had a thyroidectomy.

Rago T, Di Coscio G, Ugolini C, Scutari M, Basolo F, Latrofa F, Romani R, Berti P, Grasso L, Braverman LE, Pinchera A, Vitti P.

Clin Endocrinol (Oxf). 2007 Sep;67(3):363-9. Epub 2007 Jun 6.


Lymphocytic thyroiditis on histology correlates with serum thyroglobulin autoantibodies in patients with papillary thyroid carcinoma: impact on detection of serum thyroglobulin.

Latrofa F, Ricci D, Montanelli L, Rocchi R, Piaggi P, Sisti E, Grasso L, Basolo F, Ugolini C, Pinchera A, Vitti P.

J Clin Endocrinol Metab. 2012 Jul;97(7):2380-7. doi: 10.1210/jc.2011-2812. Epub 2012 Apr 26.


Thyroid autoimmunity: is really associated with papillary thyroid carcinoma?

Selek A, Cetinarslan B, Tarkun I, Canturk Z, Ustuner B, Akyay Z.

Eur Arch Otorhinolaryngol. 2017 Mar;274(3):1677-1681. doi: 10.1007/s00405-016-4414-6. Epub 2016 Dec 8.


Hashimoto's thyroiditis is associated with papillary thyroid carcinoma: role of TSH and of treatment with L-thyroxine.

Fiore E, Rago T, Latrofa F, Provenzale MA, Piaggi P, Delitala A, Scutari M, Basolo F, Di Coscio G, Grasso L, Pinchera A, Vitti P.

Endocr Relat Cancer. 2011 Jul 1;18(4):429-37. doi: 10.1530/ERC-11-002. Print 2011 Aug.


FNAB of benign thyroid nodules with papillary hyperplasia: a cytological and histological evaluation.

Pusztaszeri MP, Krane JF, Cibas ES, Daniels G, Faquin WC.

Cancer Cytopathol. 2014 Sep;122(9):666-77. doi: 10.1002/cncy.21441. Epub 2014 Jun 2.


May the neutrophil/lymphocyte ratio be a predictor in the differentiation of different thyroid disorders?

Kocer D, Karakukcu C, Karaman H, Gokay F, Bayram F.

Asian Pac J Cancer Prev. 2015;16(9):3875-9.


Correlation of thyroid fine-needle aspiration with final histopathology: a case series.

Gürkan Dumlu E, Kiyak G, Bozkurt B, Tokaç M, Polat B, Cakir B, Güler G, Kiliç M.

Minerva Chir. 2013 Apr;68(2):191-7.


Association of CD1a-positive dendritic cells with papillary thyroid carcinoma in thyroid fine-needle aspirations: a cytologic and immunocytochemical evaluation.

Pusztaszeri MP, Sadow PM, Faquin WC.

Cancer Cytopathol. 2013 Apr;121(4):206-13. doi: 10.1002/cncy.21239. Epub 2012 Oct 5.


Phenotypical analysis of lymphocytes with suppressive and regulatory properties (Tregs) and NK cells in the papillary carcinoma of thyroid.

Gogali F, Paterakis G, Rassidakis GZ, Kaltsas G, Liakou CI, Gousis P, Neonakis E, Manoussakis MN, Liapi C.

J Clin Endocrinol Metab. 2012 May;97(5):1474-82. doi: 10.1210/jc.2011-1838. Epub 2012 Mar 7.


Patient outcomes following surgical management of multinodular goiter: Does multinodularity increase the risk of thyroid malignancy?

Lin YS, Wu HY, Yu MC, Hsu CC, Chao TC.

Medicine (Baltimore). 2016 Jul;95(28):e4194. doi: 10.1097/MD.0000000000004194.


Hashimoto's thyroiditis as a risk factor of papillary thyroid cancer may improve cancer prognosis.

Lun Y, Wu X, Xia Q, Han Y, Zhang X, Liu Z, Wang F, Duan Z, Xin S, Zhang J.

Otolaryngol Head Neck Surg. 2013 Mar;148(3):396-402. doi: 10.1177/0194599812472426. Epub 2013 Jan 8.


'Incidental' and 'non-incidental' thyroid papillary microcarcinomas are two different entities.

Provenzale MA, Fiore E, Ugolini C, Torregrossa L, Morganti R, Molinaro E, Miccoli P, Basolo F, Vitti P.

Eur J Endocrinol. 2016 Jun;174(6):813-20. doi: 10.1530/EJE-15-1223. Epub 2016 Mar 31.


A germline mutation (A339V) in thyroid transcription factor-1 (TITF-1/NKX2.1) in patients with multinodular goiter and papillary thyroid carcinoma.

Ngan ES, Lang BH, Liu T, Shum CK, So MT, Lau DK, Leon TY, Cherny SS, Tsai SY, Lo CY, Khoo US, Tam PK, Garcia-Barceló MM.

J Natl Cancer Inst. 2009 Feb 4;101(3):162-75. doi: 10.1093/jnci/djn471. Epub 2009 Jan 27.


The underestimated risk of cancer in patients with multinodular goiters after a benign fine needle aspiration.

Campbell MJ, Seib CD, Candell L, Gosnell JE, Duh QY, Clark OH, Shen WT.

World J Surg. 2015 Mar;39(3):695-700. doi: 10.1007/s00268-014-2854-y.


The use of fine-needle aspiration biopsy under ultrasound guidance to assess the risk of malignancy in patients with a multinodular goiter.

Tollin SR, Mery GM, Jelveh N, Fallon EF, Mikhail M, Blumenfeld W, Perlmutter S.

Thyroid. 2000 Mar;10(3):235-41.


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