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The LKB1-AMPK pathway: metabolism and growth control in tumour suppression.

Shackelford DB, Shaw RJ.

Nat Rev Cancer. 2009 Aug;9(8):563-75. doi: 10.1038/nrc2676.


Important role of the LKB1-AMPK pathway in suppressing tumorigenesis in PTEN-deficient mice.

Huang X, Wullschleger S, Shpiro N, McGuire VA, Sakamoto K, Woods YL, McBurnie W, Fleming S, Alessi DR.

Biochem J. 2008 Jun 1;412(2):211-21. doi: 10.1042/BJ20080557.


LKB1 and AMP-activated protein kinase control of mTOR signalling and growth.

Shaw RJ.

Acta Physiol (Oxf). 2009 May;196(1):65-80. doi: 10.1111/j.1748-1716.2009.01972.x. Epub 2009 Feb 19. Review.


LKB1/AMPK/mTOR signaling pathway in hematological malignancies: from metabolism to cancer cell biology.

Green AS, Chapuis N, Lacombe C, Mayeux P, Bouscary D, Tamburini J.

Cell Cycle. 2011 Jul 1;10(13):2115-20. Epub 2011 Jul 1. Review.


Negative regulation of the LKB1/AMPK pathway by ERK in human acute myeloid leukemia cells.

Kawashima I, Mitsumori T, Nozaki Y, Yamamoto T, Shobu-Sueki Y, Nakajima K, Kirito K.

Exp Hematol. 2015 Jul;43(7):524-33.e1. doi: 10.1016/j.exphem.2015.03.005. Epub 2015 Apr 4.


LKB1 and AMPK family signaling: the intimate link between cell polarity and energy metabolism.

Jansen M, Ten Klooster JP, Offerhaus GJ, Clevers H.

Physiol Rev. 2009 Jul;89(3):777-98. doi: 10.1152/physrev.00026.2008. Review.


Metformin and cancer.

Vallianou NG, Evangelopoulos A, Kazazis C.

Rev Diabet Stud. 2013 Winter;10(4):228-35. doi: 10.1900/RDS.2013.10.228. Epub 2014 Feb 10. Review.


The tumor suppressor LKB1 kinase directly activates AMP-activated kinase and regulates apoptosis in response to energy stress.

Shaw RJ, Kosmatka M, Bardeesy N, Hurley RL, Witters LA, DePinho RA, Cantley LC.

Proc Natl Acad Sci U S A. 2004 Mar 9;101(10):3329-35. Epub 2004 Feb 25.


AMP-activated protein kinase in metabolic control and insulin signaling.

Towler MC, Hardie DG.

Circ Res. 2007 Feb 16;100(3):328-41. Review.


Role of AMP-activated protein kinase in cancer therapy.

Rehman G, Shehzad A, Khan AL, Hamayun M.

Arch Pharm (Weinheim). 2014 Jul;347(7):457-68. doi: 10.1002/ardp.201300402. Epub 2014 Mar 28. Review.


Activity of LKB1 and AMPK-related kinases in skeletal muscle: effects of contraction, phenformin, and AICAR.

Sakamoto K, G├Âransson O, Hardie DG, Alessi DR.

Am J Physiol Endocrinol Metab. 2004 Aug;287(2):E310-7. Epub 2004 Apr 6.


AMP-activated protein kinase (AMPK) beyond metabolism: a novel genomic stress sensor participating in the DNA damage response pathway.

Sanli T, Steinberg GR, Singh G, Tsakiridis T.

Cancer Biol Ther. 2014 Feb;15(2):156-69. doi: 10.4161/cbt.26726. Epub 2013 Nov 1. Review.


The kinase LKB1 mediates glucose homeostasis in liver and therapeutic effects of metformin.

Shaw RJ, Lamia KA, Vasquez D, Koo SH, Bardeesy N, Depinho RA, Montminy M, Cantley LC.

Science. 2005 Dec 9;310(5754):1642-6. Epub 2005 Nov 24.


Targeting LKB1 signaling in cancer.

Korsse SE, Peppelenbosch MP, van Veelen W.

Biochim Biophys Acta. 2013 Apr;1835(2):194-210. doi: 10.1016/j.bbcan.2012.12.006. Epub 2012 Dec 31. Review.


Rho-kinase inhibition ameliorates metabolic disorders through activation of AMPK pathway in mice.

Noda K, Nakajima S, Godo S, Saito H, Ikeda S, Shimizu T, Enkhjargal B, Fukumoto Y, Tsukita S, Yamada T, Katagiri H, Shimokawa H.

PLoS One. 2014 Nov 3;9(11):e110446. doi: 10.1371/journal.pone.0110446. eCollection 2014.


LKB1 and AMPK in cell polarity and division.

Williams T, Brenman JE.

Trends Cell Biol. 2008 Apr;18(4):193-8. doi: 10.1016/j.tcb.2008.01.008. Epub 2008 Mar 7. Review.


GSK-3╬▓ controls autophagy by modulating LKB1-AMPK pathway in prostate cancer cells.

Sun A, Li C, Chen R, Huang Y, Chen Q, Cui X, Liu H, Thrasher JB, Li B.

Prostate. 2016 Feb;76(2):172-83. doi: 10.1002/pros.23106. Epub 2015 Oct 6.


Liver Kinase B1/AMP-Activated Protein Kinase Pathway Activation Attenuated the Progression of Endotoxemia in the Diabetic Mice.

Yang Y, Dong R, Hu D, Chen Z, Fu M, Wang DW, Xu X, Tu L.

Cell Physiol Biochem. 2017;42(2):761-779. doi: 10.1159/000478068. Epub 2017 Jun 19.


LKB1 and AMPK maintain epithelial cell polarity under energetic stress.

Mirouse V, Swick LL, Kazgan N, St Johnston D, Brenman JE.

J Cell Biol. 2007 May 7;177(3):387-92. Epub 2007 Apr 30. Retraction in: J Cell Biol. 2013 Oct 28;203(2):373.

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