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Items: 1 to 20 of 144

1.

Association of serum cotinine level with a cluster of three nicotinic acetylcholine receptor genes (CHRNA3/CHRNA5/CHRNB4) on chromosome 15.

Keskitalo K, Broms U, Heliövaara M, Ripatti S, Surakka I, Perola M, Pitkäniemi J, Peltonen L, Aromaa A, Kaprio J.

Hum Mol Genet. 2009 Oct 15;18(20):4007-12. doi: 10.1093/hmg/ddp322. Epub 2009 Jul 23.

2.

Risk gene variants for nicotine dependence in the CHRNA5-CHRNA3-CHRNB4 cluster are associated with cognitive performance.

Winterer G, Mittelstrass K, Giegling I, Lamina C, Fehr C, Brenner H, Breitling LP, Nitz B, Raum E, Müller H, Gallinat J, Gal A, Heim K, Prokisch H, Meitinger T, Hartmann AM, Möller HJ, Gieger C, Wichmann HE, Illig T, Dahmen N, Rujescu D.

Am J Med Genet B Neuropsychiatr Genet. 2010 Dec 5;153B(8):1448-58. doi: 10.1002/ajmg.b.31126. Epub 2010 Sep 30.

PMID:
20886544
3.

Associations of nicotine intake measures with CHRN genes in Finnish smokers.

Keskitalo-Vuokko K, Pitkäniemi J, Broms U, Heliövaara M, Aromaa A, Perola M, Ripatti S, Salminen O, Salomaa V, Loukola A, Kaprio J.

Nicotine Tob Res. 2011 Aug;13(8):686-90. doi: 10.1093/ntr/ntr059. Epub 2011 Apr 16.

4.

Analysis of detailed phenotype profiles reveals CHRNA5-CHRNA3-CHRNB4 gene cluster association with several nicotine dependence traits.

Broms U, Wedenoja J, Largeau MR, Korhonen T, Pitkäniemi J, Keskitalo-Vuokko K, Häppölä A, Heikkilä KH, Heikkilä K, Ripatti S, Sarin AP, Salminen O, Paunio T, Pergadia ML, Madden PA, Kaprio J, Loukola A.

Nicotine Tob Res. 2012 Jun;14(6):720-33. doi: 10.1093/ntr/ntr283. Epub 2012 Jan 12.

5.

The CHRNA5-CHRNA3-CHRNB4 nicotinic receptor subunit gene cluster affects risk for nicotine dependence in African-Americans and in European-Americans.

Saccone NL, Wang JC, Breslau N, Johnson EO, Hatsukami D, Saccone SF, Grucza RA, Sun L, Duan W, Budde J, Culverhouse RC, Fox L, Hinrichs AL, Steinbach JH, Wu M, Rice JP, Goate AM, Bierut LJ.

Cancer Res. 2009 Sep 1;69(17):6848-56. doi: 10.1158/0008-5472.CAN-09-0786. Epub 2009 Aug 25.

6.

Distinct loci in the CHRNA5/CHRNA3/CHRNB4 gene cluster are associated with onset of regular smoking.

Stephens SH, Hartz SM, Hoft NR, Saccone NL, Corley RC, Hewitt JK, Hopfer CJ, Breslau N, Coon H, Chen X, Ducci F, Dueker N, Franceschini N, Frank J, Han Y, Hansel NN, Jiang C, Korhonen T, Lind PA, Liu J, Lyytikäinen LP, Michel M, Shaffer JR, Short SE, Sun J, Teumer A, Thompson JR, Vogelzangs N, Vink JM, Wenzlaff A, Wheeler W, Yang BZ, Aggen SH, Balmforth AJ, Baumeister SE, Beaty TH, Benjamin DJ, Bergen AW, Broms U, Cesarini D, Chatterjee N, Chen J, Cheng YC, Cichon S, Couper D, Cucca F, Dick D, Foroud T, Furberg H, Giegling I, Gillespie NA, Gu F, Hall AS, Hällfors J, Han S, Hartmann AM, Heikkilä K, Hickie IB, Hottenga JJ, Jousilahti P, Kaakinen M, Kähönen M, Koellinger PD, Kittner S, Konte B, Landi MT, Laatikainen T, Leppert M, Levy SM, Mathias RA, McNeil DW, Medland SE, Montgomery GW, Murray T, Nauck M, North KE, Paré PD, Pergadia M, Ruczinski I, Salomaa V, Viikari J, Willemsen G, Barnes KC, Boerwinkle E, Boomsma DI, Caporaso N, Edenberg HJ, Francks C, Gelernter J, Grabe HJ, Hops H, Jarvelin MR, Johannesson M, Kendler KS, Lehtimäki T, Magnusson PK, Marazita ML, Marchini J, Mitchell BD, Nöthen MM, Penninx BW, Raitakari O, Rietschel M, Rujescu D, Samani NJ, Schwartz AG, Shete S, Spitz M, Swan GE, Völzke H, Veijola J, Wei Q, Amos C, Cannon DS, Grucza R, Hatsukami D, Heath A, Johnson EO, Kaprio J, Madden P, Martin NG, Stevens VL, Weiss RB, Kraft P, Bierut LJ, Ehringer MA.

Genet Epidemiol. 2013 Dec;37(8):846-59. doi: 10.1002/gepi.21760. Epub 2013 Nov 1.

7.

Association between genetic variants on chromosome 15q25 locus and several nicotine dependence traits in Polish population: a case-control study.

Buczkowski K, Sieminska A, Linkowska K, Czachowski S, Przybylski G, Jassem E, Grzybowski T.

Biomed Res Int. 2015;2015:350348. doi: 10.1155/2015/350348. Epub 2015 Jan 6.

8.

Markers in the 15q24 nicotinic receptor subunit gene cluster (CHRNA5-A3-B4) predict severity of nicotine addiction and response to smoking cessation therapy.

Sarginson JE, Killen JD, Lazzeroni LC, Fortmann SP, Ryan HS, Schatzberg AF, Murphy GM Jr.

Am J Med Genet B Neuropsychiatr Genet. 2011 Apr;156B(3):275-84. doi: 10.1002/ajmg.b.31155. Epub 2011 Jan 25.

PMID:
21268243
10.

A common genetic variant in the 15q24 nicotinic acetylcholine receptor gene cluster (CHRNA5-CHRNA3-CHRNB4) is associated with a reduced ability of women to quit smoking in pregnancy.

Freathy RM, Ring SM, Shields B, Galobardes B, Knight B, Weedon MN, Smith GD, Frayling TM, Hattersley AT.

Hum Mol Genet. 2009 Aug 1;18(15):2922-7. doi: 10.1093/hmg/ddp216. Epub 2009 May 9.

11.

A multiancestry study identifies novel genetic associations with CHRNA5 methylation in human brain and risk of nicotine dependence.

Hancock DB, Wang JC, Gaddis NC, Levy JL, Saccone NL, Stitzel JA, Goate A, Bierut LJ, Johnson EO.

Hum Mol Genet. 2015 Oct 15;24(20):5940-54. doi: 10.1093/hmg/ddv303. Epub 2015 Jul 28.

12.

Association and interaction analysis of variants in CHRNA5/CHRNA3/CHRNB4 gene cluster with nicotine dependence in African and European Americans.

Li MD, Xu Q, Lou XY, Payne TJ, Niu T, Ma JZ.

Am J Med Genet B Neuropsychiatr Genet. 2010 Apr 5;153B(3):745-56. doi: 10.1002/ajmg.b.31043.

13.

Contribution of Variants in CHRNA5/A3/B4 Gene Cluster on Chromosome 15 to Tobacco Smoking: From Genetic Association to Mechanism.

Wen L, Jiang K, Yuan W, Cui W, Li MD.

Mol Neurobiol. 2016 Jan;53(1):472-484. doi: 10.1007/s12035-014-8997-x. Epub 2014 Dec 5. Review.

PMID:
25471942
14.

Variants located upstream of CHRNB4 on chromosome 15q25.1 are associated with age at onset of daily smoking and habitual smoking.

Kapoor M, Wang JC, Bertelsen S, Bucholz K, Budde JP, Hinrichs A, Agrawal A, Brooks A, Chorlian D, Dick D, Hesselbrock V, Foroud T, Kramer J, Kuperman S, Manz N, Nurnberger J Jr, Porjesz B, Rice J, Tischfield J, Xuei X, Schuckit M, Edenberg HJ, Bierut LJ, Goate AM.

PLoS One. 2012;7(3):e33513. doi: 10.1371/journal.pone.0033513. Epub 2012 Mar 16.

15.

Alpha-5 and -3 nicotinic receptor gene variants predict nicotine dependence but not cessation: findings from the COMMIT cohort.

Bousman CA, Rivard C, Haese JD, Ambrosone C, Hyland A.

Am J Med Genet B Neuropsychiatr Genet. 2012 Mar;159B(2):227-35. doi: 10.1002/ajmg.b.32019. Epub 2012 Jan 5.

16.

Association of the nicotine metabolite ratio and CHRNA5/CHRNA3 polymorphisms with smoking rate among treatment-seeking smokers.

Falcone M, Jepson C, Benowitz N, Bergen AW, Pinto A, Wileyto EP, Baldwin D, Tyndale RF, Lerman C, Ray R.

Nicotine Tob Res. 2011 Jun;13(6):498-503. doi: 10.1093/ntr/ntr012. Epub 2011 Mar 8.

17.

Variation in the nicotinic acetylcholine receptor gene cluster CHRNA5-CHRNA3-CHRNB4 and its interaction with recent tobacco use influence cognitive flexibility.

Zhang H, Kranzler HR, Poling J, Gelernter J.

Neuropsychopharmacology. 2010 Oct;35(11):2211-24. doi: 10.1038/npp.2010.95. Epub 2010 Jul 14.

18.

Association between genetic variants on chromosome 15q25 locus and objective measures of tobacco exposure.

Munafò MR, Timofeeva MN, Morris RW, Prieto-Merino D, Sattar N, Brennan P, Johnstone EC, Relton C, Johnson PC, Walther D, Whincup PH, Casas JP, Uhl GR, Vineis P, Padmanabhan S, Jefferis BJ, Amuzu A, Riboli E, Upton MN, Aveyard P, Ebrahim S, Hingorani AD, Watt G, Palmer TM, Timpson NJ; EPIC Study Group, Davey Smith G.

J Natl Cancer Inst. 2012 May 16;104(10):740-8. doi: 10.1093/jnci/djs191. Epub 2012 Apr 25.

19.

Multiple distinct risk loci for nicotine dependence identified by dense coverage of the complete family of nicotinic receptor subunit (CHRN) genes.

Saccone NL, Saccone SF, Hinrichs AL, Stitzel JA, Duan W, Pergadia ML, Agrawal A, Breslau N, Grucza RA, Hatsukami D, Johnson EO, Madden PA, Swan GE, Wang JC, Goate AM, Rice JP, Bierut LJ.

Am J Med Genet B Neuropsychiatr Genet. 2009 Jun 5;150B(4):453-66. doi: 10.1002/ajmg.b.30828.

20.

Chromosome 15q25 (CHRNA3-CHRNB4) Variation Indirectly Impacts Lung Cancer Risk in Chinese Males.

Zhang Y, Jiang M, Li Q, Liang W, He Q, Chen W, He J.

PLoS One. 2016 Mar 4;11(3):e0149946. doi: 10.1371/journal.pone.0149946. eCollection 2016.

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