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Items: 1 to 20 of 107


Structural characterization of a viral NEIL1 ortholog unliganded and bound to abasic site-containing DNA.

Imamura K, Wallace SS, Doublié S.

J Biol Chem. 2009 Sep 18;284(38):26174-83. doi: 10.1074/jbc.M109.021907. Epub 2009 Jul 22.


Human endonuclease VIII-like (NEIL) proteins in the giant DNA Mimivirus.

Bandaru V, Zhao X, Newton MR, Burrows CJ, Wallace SS.

DNA Repair (Amst). 2007 Nov;6(11):1629-41. Epub 2007 Jul 12.


Structural and biochemical studies of a plant formamidopyrimidine-DNA glycosylase reveal why eukaryotic Fpg glycosylases do not excise 8-oxoguanine.

Duclos S, Aller P, Jaruga P, Dizdaroglu M, Wallace SS, Doublié S.

DNA Repair (Amst). 2012 Sep 1;11(9):714-25. doi: 10.1016/j.dnarep.2012.06.004. Epub 2012 Jul 11.


Structure of the uncomplexed DNA repair enzyme endonuclease VIII indicates significant interdomain flexibility.

Golan G, Zharkov DO, Feinberg H, Fernandes AS, Zaika EI, Kycia JH, Grollman AP, Shoham G.

Nucleic Acids Res. 2005 Sep 6;33(15):5006-16. Print 2005.


Structural characterization of viral ortholog of human DNA glycosylase NEIL1 bound to thymine glycol or 5-hydroxyuracil-containing DNA.

Imamura K, Averill A, Wallace SS, Doublié S.

J Biol Chem. 2012 Feb 3;287(6):4288-98. doi: 10.1074/jbc.M111.315309. Epub 2011 Dec 14.


Structural investigation of a viral ortholog of human NEIL2/3 DNA glycosylases.

Prakash A, Eckenroth BE, Averill AM, Imamura K, Wallace SS, Doublié S.

DNA Repair (Amst). 2013 Dec;12(12):1062-71. doi: 10.1016/j.dnarep.2013.09.004. Epub 2013 Oct 10.


The crystal structure of human endonuclease VIII-like 1 (NEIL1) reveals a zincless finger motif required for glycosylase activity.

Doublié S, Bandaru V, Bond JP, Wallace SS.

Proc Natl Acad Sci U S A. 2004 Jul 13;101(28):10284-9. Epub 2004 Jul 1.


Crystallization and preliminary crystallographic analysis of endonuclease VIII in its uncomplexed form.

Golan G, Zharkov DO, Fernandes AS, Zaika E, Kycia JH, Wawrzak Z, Grollman AP, Shoham G.

Acta Crystallogr D Biol Crystallogr. 2004 Aug;60(Pt 8):1476-80. Epub 2004 Jul 21.


Conformational dynamics of the interaction of Escherichia coli endonuclease VIII with DNA substrates.

Kuznetsov NA, Koval VV, Zharkov DO, Fedorova OS.

DNA Repair (Amst). 2012 Nov 1;11(11):884-91. doi: 10.1016/j.dnarep.2012.08.004. Epub 2012 Sep 19.


Structural analysis of an Escherichia coli endonuclease VIII covalent reaction intermediate.

Zharkov DO, Golan G, Gilboa R, Fernandes AS, Gerchman SE, Kycia JH, Rieger RA, Grollman AP, Shoham G.

EMBO J. 2002 Feb 15;21(4):789-800.


The Fpg/Nei family of DNA glycosylases: substrates, structures, and search for damage.

Prakash A, Doublié S, Wallace SS.

Prog Mol Biol Transl Sci. 2012;110:71-91. doi: 10.1016/B978-0-12-387665-2.00004-3. Review.


Using shifts in amino acid frequency and substitution rate to identify latent structural characters in base-excision repair enzymes.

Barrantes-Reynolds R, Wallace SS, Bond JP.

PLoS One. 2011;6(10):e25246. doi: 10.1371/journal.pone.0025246. Epub 2011 Oct 6.


Structural characterization of the Fpg family of DNA glycosylases.

Zharkov DO, Shoham G, Grollman AP.

DNA Repair (Amst). 2003 Aug 12;2(8):839-62. Review.


Structure of T4 pyrimidine dimer glycosylase in a reduced imine covalent complex with abasic site-containing DNA.

Golan G, Zharkov DO, Grollman AP, Dodson ML, McCullough AK, Lloyd RS, Shoham G.

J Mol Biol. 2006 Sep 15;362(2):241-58. Epub 2006 Jul 7.


Genome and cancer single nucleotide polymorphisms of the human NEIL1 DNA glycosylase: activity, structure, and the effect of editing.

Prakash A, Carroll BL, Sweasy JB, Wallace SS, Doublié S.

DNA Repair (Amst). 2014 Feb;14:17-26. doi: 10.1016/j.dnarep.2013.12.003. Epub 2013 Dec 29.


Conformational Dynamics of DNA Repair by Escherichia coli Endonuclease III.

Kuznetsov NA, Kladova OA, Kuznetsova AA, Ishchenko AA, Saparbaev MK, Zharkov DO, Fedorova OS.

J Biol Chem. 2015 Jun 5;290(23):14338-49. doi: 10.1074/jbc.M114.621128. Epub 2015 Apr 13.


Human Nei-like protein NEIL3 has AP lyase activity specific for single-stranded DNA and confers oxidative stress resistance in Escherichia coli mutant.

Takao M, Oohata Y, Kitadokoro K, Kobayashi K, Iwai S, Yasui A, Yonei S, Zhang QM.

Genes Cells. 2009 Feb;14(2):261-70. doi: 10.1111/j.1365-2443.2008.01271.x. Epub 2008 Jan 15.


Zinc finger oxidation of Fpg/Nei DNA glycosylases by 2-thioxanthine: biochemical and X-ray structural characterization.

Biela A, Coste F, Culard F, Guerin M, Goffinont S, Gasteiger K, Cieśla J, Winczura A, Kazimierczuk Z, Gasparutto D, Carell T, Tudek B, Castaing B.

Nucleic Acids Res. 2014;42(16):10748-61. doi: 10.1093/nar/gku613. Epub 2014 Aug 20.

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