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Low concentrations of diindolylmethane, a metabolite of indole-3-carbinol, protect against oxidative stress in a BRCA1-dependent manner.

Fan S, Meng Q, Saha T, Sarkar FH, Rosen EM.

Cancer Res. 2009 Aug 1;69(15):6083-91. doi: 10.1158/0008-5472.CAN-08-3309. Epub 2009 Jul 21.


3,3'-diindolylmethane induction of p75NTR-dependent cell death via the p38 mitogen-activated protein kinase pathway in prostate cancer cells.

Khwaja FS, Wynne S, Posey I, Djakiew D.

Cancer Prev Res (Phila). 2009 Jun;2(6):566-71. doi: 10.1158/1940-6207.CAPR-08-0202. Epub 2009 May 26.


DIM (3,3'-diindolylmethane) confers protection against ionizing radiation by a unique mechanism.

Fan S, Meng Q, Xu J, Jiao Y, Zhao L, Zhang X, Sarkar FH, Brown ML, Dritschilo A, Rosen EM.

Proc Natl Acad Sci U S A. 2013 Nov 12;110(46):18650-5. doi: 10.1073/pnas.1308206110. Epub 2013 Oct 14.


BRCA1 mutations drive oxidative stress and glycolysis in the tumor microenvironment: implications for breast cancer prevention with antioxidant therapies.

Martinez-Outschoorn UE, Balliet R, Lin Z, Whitaker-Menezes D, Birbe RC, Bombonati A, Pavlides S, Lamb R, Sneddon S, Howell A, Sotgia F, Lisanti MP.

Cell Cycle. 2012 Dec 1;11(23):4402-13. doi: 10.4161/cc.22776. Epub 2012 Nov 21.


3,3'-Diindolylmethane decreases VCAM-1 expression and alleviates experimental colitis via a BRCA1-dependent antioxidant pathway.

Huang Z, Zuo L, Zhang Z, Liu J, Chen J, Dong L, Zhang J.

Free Radic Biol Med. 2011 Jan 15;50(2):228-36. doi: 10.1016/j.freeradbiomed.2010.10.703. Epub 2010 Oct 26.


The dietary phytochemical 3,3'-diindolylmethane induces G2/M arrest and apoptosis in oral squamous cell carcinoma by modulating Akt-NF-κB, MAPK, and p53 signaling.

Weng JR, Bai LY, Chiu CF, Wang YC, Tsai MH.

Chem Biol Interact. 2012 Feb 5;195(3):224-30. doi: 10.1016/j.cbi.2012.01.003. Epub 2012 Jan 24.


Inactivation of NF-kappaB by 3,3'-diindolylmethane contributes to increased apoptosis induced by chemotherapeutic agent in breast cancer cells.

Rahman KM, Ali S, Aboukameel A, Sarkar SH, Wang Z, Philip PA, Sakr WA, Raz A.

Mol Cancer Ther. 2007 Oct;6(10):2757-65. Epub 2007 Oct 3.


3,3'-Diindolylmethane inhibits lipopolysaccharide-induced microglial hyperactivation and attenuates brain inflammation.

Kim HW, Kim J, Kim J, Lee S, Choi BR, Han JS, Lee KW, Lee HJ.

Toxicol Sci. 2014 Jan;137(1):158-67. doi: 10.1093/toxsci/kft240. Epub 2013 Oct 26.


Low levels of 3,3'-diindolylmethane activate estrogen receptor α and induce proliferation of breast cancer cells in the absence of estradiol.

Marques M, Laflamme L, Benassou I, Cissokho C, Guillemette B, Gaudreau L.

BMC Cancer. 2014 Jul 21;14:524. doi: 10.1186/1471-2407-14-524.


BRCA1 interacts with Nrf2 to regulate antioxidant signaling and cell survival.

Gorrini C, Baniasadi PS, Harris IS, Silvester J, Inoue S, Snow B, Joshi PA, Wakeham A, Molyneux SD, Martin B, Bouwman P, Cescon DW, Elia AJ, Winterton-Perks Z, Cruickshank J, Brenner D, Tseng A, Musgrave M, Berman HK, Khokha R, Jonkers J, Mak TW, Gauthier ML.

J Exp Med. 2013 Jul 29;210(8):1529-44. doi: 10.1084/jem.20121337. Epub 2013 Jul 15.


Antiangiogenic effects of indole-3-carbinol and 3,3'-diindolylmethane are associated with their differential regulation of ERK1/2 and Akt in tube-forming HUVEC.

Kunimasa K, Kobayashi T, Kaji K, Ohta T.

J Nutr. 2010 Jan;140(1):1-6. doi: 10.3945/jn.109.112359. Epub 2009 Nov 4.


Suppression of breast cancer invasion and migration by indole-3-carbinol: associated with up-regulation of BRCA1 and E-cadherin/catenin complexes.

Meng Q, Qi M, Chen DZ, Yuan R, Goldberg ID, Rosen EM, Auborn K, Fan S.

J Mol Med (Berl). 2000;78(3):155-65.


Wild-type BRCA1, but not mutated BRCA1, regulates the expression of the nuclear form of beta-catenin.

Li H, Sekine M, Tung N, Avraham HK.

Mol Cancer Res. 2010 Mar;8(3):407-20. doi: 10.1158/1541-7786.MCR-09-0403. Epub 2010 Mar 9.


3,3'-diindolylmethane and paclitaxel act synergistically to promote apoptosis in HER2/Neu human breast cancer cells.

McGuire KP, Ngoubilly N, Neavyn M, Lanza-Jacoby S.

J Surg Res. 2006 May 15;132(2):208-13. Epub 2006 Mar 31.


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