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19605406,20590594,26183715,23845849,26667450,20182390,25934708,28602977,30683944,29238973,17440100,24326363,25633045,24025152,21305255,22641480,22952775,25482928,26213847,16060994,24491405,31906106,34954267,30155839,17145834,17444865,20864511,19142175,17114015,20483353,24462376,16204081,31736340,20646665,26682870,19816711,22270965,28536008,18841326,23165325,22710877,22532602,25030587,25240403,21720559,19908231,25197966,21440986,10341297,26255562,19531570,16052215,25884642,30399592,17967505,22513291,19966835,21935918,21666438,22378302,30083262,20370686,21944112,18652313,22832932,28095907,29328487,24838526,26909608,20699664,20495354,25499121,22312312,23497499,25024609,20137856,20523344,23000892,18442812,24040444,21743963,23047891,19405118,31078621,29849873,26684804,21468555,18023527,15464472,22172707,24619961,33744388,30782607,22266985,15947928,25684468,24819705,30486896,16914581,27576197,14750167,25237909,31584613,22030254,20388782,28797284,18297287,24953335,15363970,17179482,25344906,23007710,25448549,18765534,21226944,25242370,24952679,32282368,30844294,17671683,20103639,24519751,26176887,21843259,23146955,29575133,19506533,17339366,32897433,22486854,21115915,24424498,22679728,20714148,32967656,26495790,22334000,15585396,18430374,15131028,25725418,18595135,28028124,24214898,33011221,26254348,25669977,30267303,26453936,23674070,20811703,23588416,30341797,22783925,23835677,27845899,34354046,24522113,26879926,20606044,32599367,19823097,27658776,27499118,24023491,17470512,17332349,15735038,19549912,12107556,22695089,15647844,29848706,11668508,21304529,32111094,12738744,19661331,21768779,11516199,33986399,20564622,21971120,26634526,22348037,29666220,11504793,23142291,20209107,25936828,18078709,22211100,25937078,19628080,26774265,19730150,23541946,23293055,23086228,32423820,21570961,21954965,20118008,28134290,24680816,19509273,24081907,16006755,19029951,19738614,25260978,34320467,25517919,23470564,23174220,28089829,34239352,16112422,16061881,21993922,19672266,25841339,27721241,29389804,16490547,24359526,23274410,24403454,17559882,27780828,27779693,32526702,23041978,30308458,31802375,15447848,35716217,33650657,23217280,29039524,23874680,29155177,28153717,22057484,22102891,21236335,22573342,29115428,25646691,21375679,26961182,21525939,20647339,28318081,10340887,17726607,19408690,22552257,18790769,26203552,18789834,24764328,15320962,16243825,26851020,17378914,21347515,32949679,27322077,34667112,16929163,17164759,15269152,26028101,31570427,22873289,19428321,27889645,15867251,21402145,22967941,10505042,30365143,21544815,23899521,11490361,17786181,21844567,31855560,15585638,30814617,34187428,33760105,15770523,31762191,26013168,16397047,34321315,19880242,26035122,25257100,11590323,31521276,34062410,35165514,22200913,17700025,21673052,16317290,12943815,22935679,26887043,15015576,21945432,14654564,32379301,25987640,25970774,16552573,32661823,36575213,18427961,20428806,25232128,23801065,25331547,16952707,27391262,15497704,12445678,25550550,18089714,15517865,23940717,16425399,25849286,20851464,33301843,21609464,30084546,15967119,18351299,29215048,25125675,23392708,19399788,26252969,19682434,16078561,23018618,27093343,22246215,26358255,20066470,23143189,26397991,16467107,11034810,26959746,16510697,27209702,28739697,22489660,16242078,22617428,33381963,22788366,24337869,21608232,28349292,26252371,24366069,36157930,21371545,25584895,26604207,30454541,19467571,23148997,16855376,25060520,36423542,16088235,29653181,15161033,24598658,18383823,18227973,16138007,29704518,15548711,14977854,23511429,28366930,10762639,32277442,19942398,26806350,29653962,15476743,19395473,20651363,24068909,11948132,29186204,27749787,10811472,8652262,9772293,9515801,30347681,18840529,21092190,19634915,26450014,21216936,21464824,24040280,22416395,33931720,20829040,23748821,15581479,18666046,23030589,11062701,22797386,32019711,16388521,28766646,24401833,18430611,31519586,23394599,24200995,25874330,15571253,16275994,21939359,22888657,36550419,22390765,23857605,20490800,15374965,15571290,30579733,22929882,17429628,36296442,35795999,25167883,15494643,35412401,18050344,16005145,36918040,36297341,32705165,18307306,35327319,18386611,33310004,37121563,36739330,36882036[uid]

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Cucurbitacin B induces apoptosis by inhibition of the JAK/STAT pathway and potentiates antiproliferative effects of gemcitabine on pancreatic cancer cells.

Thoennissen NH, Iwanski GB, Doan NB, Okamoto R, Lin P, Abbassi S, Song JH, Yin D, Toh M, Xie WD, Said JW, Koeffler HP. Thoennissen NH, et al. Cancer Res. 2009 Jul 15;69(14):5876-84. doi: 10.1158/0008-5472.CAN-09-0536. Cancer Res. 2009. PMID: 19605406

Cucurbitacin B, a novel in vivo potentiator of gemcitabine with low toxicity in the treatment of pancreatic cancer.

Iwanski GB, Lee DH, En-Gal S, Doan NB, Castor B, Vogt M, Toh M, Bokemeyer C, Said JW, Thoennissen NH, Koeffler HP. Iwanski GB, et al. Br J Pharmacol. 2010 Jun;160(4):998-1007. doi: 10.1111/j.1476-5381.2010.00741.x. Br J Pharmacol. 2010. PMID: 20590594 Free PMC article.

Treatment with cucurbitacin B alone and in combination with gefitinib induces cell cycle inhibition and apoptosis via EGFR and JAK/STAT pathway in human colorectal cancer cell lines.

Yar Saglam AS, Alp E, Elmazoglu Z, Menevse S. Yar Saglam AS, et al. Hum Exp Toxicol. 2016 May;35(5):526-43. doi: 10.1177/0960327115595686. Epub 2015 Jul 16. Hum Exp Toxicol. 2016. PMID: 26183715

Andrographolide causes apoptosis via inactivation of STAT3 and Akt and potentiates antitumor activity of gemcitabine in pancreatic cancer.

Bao GQ, Shen BY, Pan CP, Zhang YJ, Shi MM, Peng CH. Bao GQ, et al. Toxicol Lett. 2013 Sep 12;222(1):23-35. doi: 10.1016/j.toxlet.2013.06.241. Epub 2013 Jul 8. Toxicol Lett. 2013. PMID: 23845849

Piperlongumine Suppresses Growth and Sensitizes Pancreatic Tumors to Gemcitabine in a Xenograft Mouse Model by Modulating the NF-kappa B Pathway.

Wang Y, Wu X, Zhou Y, Jiang H, Pan S, Sun B. Wang Y, et al. Cancer Prev Res (Phila). 2016 Mar;9(3):234-44. doi: 10.1158/1940-6207.CAPR-15-0306. Epub 2015 Dec 14. Cancer Prev Res (Phila). 2016. PMID: 26667450

Inhibition of pancreatic cancer cell growth by cucurbitacin B through modulation of signal transducer and activator of transcription 3 signaling.

Zhang M, Sun C, Shan X, Yang X, Li-Ling J, Deng Y. Zhang M, et al. Pancreas. 2010 Aug;39(6):923-9. doi: 10.1097/MPA.0b013e3181ce719e. Pancreas. 2010. PMID: 20182390

Selective Nuclear Export Inhibitor KPT-330 Enhances the Antitumor Activity of Gemcitabine in Human Pancreatic Cancer.

Kazim S, Malafa MP, Coppola D, Husain K, Zibadi S, Kashyap T, Crochiere M, Landesman Y, Rashal T, Sullivan DM, Mahipal A. Kazim S, et al. Mol Cancer Ther. 2015 Jul;14(7):1570-81. doi: 10.1158/1535-7163.MCT-15-0104. Epub 2015 May 1. Mol Cancer Ther. 2015. PMID: 25934708 Free PMC article.

BRM/SMARCA2 promotes the proliferation and chemoresistance of pancreatic cancer cells by targeting JAK2/STAT3 signaling.

Zhang Z, Wang F, Du C, Guo H, Ma L, Liu X, Kornmann M, Tian X, Yang Y. Zhang Z, et al. Cancer Lett. 2017 Aug 28;402:213-224. doi: 10.1016/j.canlet.2017.05.006. Epub 2017 Jun 7. Cancer Lett. 2017. PMID: 28602977

S-Adenosylmethionine synergistically enhances the antitumor effect of gemcitabine against pancreatic cancer through JAK2/STAT3 pathway.

Liu Y, Bi T, Liu L, Gao Q, Shen G, Qin L. Liu Y, et al. Naunyn Schmiedebergs Arch Pharmacol. 2019 May;392(5):615-622. doi: 10.1007/s00210-019-01617-2. Epub 2019 Jan 25. Naunyn Schmiedebergs Arch Pharmacol. 2019. PMID: 30683944 Retracted.

Demethylzeylasteral (ZST93) inhibits cell growth and enhances cell chemosensitivity to gemcitabine in human pancreatic cancer cells via apoptotic and autophagic pathways.

Wang F, Tian X, Zhang Z, Ma Y, Xie X, Liang J, Yang C, Yang Y. Wang F, et al. Int J Cancer. 2018 May 1;142(9):1938-1951. doi: 10.1002/ijc.31211. Epub 2018 Jan 4. Int J Cancer. 2018. PMID: 29238973 Free article.

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