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Bone morphogenetic protein signaling is impaired in an HFE knockout mouse model of hemochromatosis.

Corradini E, Garuti C, Montosi G, Ventura P, Andriopoulos B Jr, Lin HY, Pietrangelo A, Babitt JL.

Gastroenterology. 2009 Oct;137(4):1489-97. doi: 10.1053/j.gastro.2009.06.057. Epub 2009 Jul 7.


Iron regulation of hepcidin despite attenuated Smad1,5,8 signaling in mice without transferrin receptor 2 or Hfe.

Corradini E, Rozier M, Meynard D, Odhiambo A, Lin HY, Feng Q, Migas MC, Britton RS, Babitt JL, Fleming RE.

Gastroenterology. 2011 Nov;141(5):1907-14. doi: 10.1053/j.gastro.2011.06.077. Epub 2011 Jul 13.


BMP/Smad signaling is not enhanced in Hfe-deficient mice despite increased Bmp6 expression.

Kautz L, Meynard D, Besson-Fournier C, Darnaud V, Al Saati T, Coppin H, Roth MP.

Blood. 2009 Sep 17;114(12):2515-20. doi: 10.1182/blood-2009-02-206771. Epub 2009 Jul 21.


BMP6 treatment compensates for the molecular defect and ameliorates hemochromatosis in Hfe knockout mice.

Corradini E, Schmidt PJ, Meynard D, Garuti C, Montosi G, Chen S, Vukicevic S, Pietrangelo A, Lin HY, Babitt JL.

Gastroenterology. 2010 Nov;139(5):1721-9. doi: 10.1053/j.gastro.2010.07.044. Epub 2010 Aug 1.


Defective bone morphogenic protein signaling underlies hepcidin deficiency in HFE hereditary hemochromatosis.

Ryan JD, Ryan E, Fabre A, Lawless MW, Crowe J.

Hepatology. 2010 Oct;52(4):1266-73. doi: 10.1002/hep.23814.


Differing impact of the deletion of hemochromatosis-associated molecules HFE and transferrin receptor-2 on the iron phenotype of mice lacking bone morphogenetic protein 6 or hemojuvelin.

Latour C, Besson-Fournier C, Meynard D, Silvestri L, Gourbeyre O, Aguilar-Martinez P, Schmidt PJ, Fleming MD, Roth MP, Coppin H.

Hepatology. 2016 Jan;63(1):126-37. doi: 10.1002/hep.28254. Epub 2015 Nov 12.


Evidence for distinct pathways of hepcidin regulation by acute and chronic iron loading in mice.

Ramos E, Kautz L, Rodriguez R, Hansen M, Gabayan V, Ginzburg Y, Roth MP, Nemeth E, Ganz T.

Hepatology. 2011 Apr;53(4):1333-41. doi: 10.1002/hep.24178.


Heterozygous Mutations in BMP6 Pro-peptide Lead to Inappropriate Hepcidin Synthesis and Moderate Iron Overload in Humans.

Daher R, Kannengiesser C, Houamel D, Lefebvre T, Bardou-Jacquet E, Ducrot N, de Kerguenec C, Jouanolle AM, Robreau AM, Oudin C, Le Gac G, Moulouel B, Loustaud-Ratti V, Bedossa P, Valla D, Gouya L, Beaumont C, Brissot P, Puy H, Karim Z, Tchernitchko D.

Gastroenterology. 2016 Mar;150(3):672-683.e4. doi: 10.1053/j.gastro.2015.10.049. Epub 2015 Nov 12.


Hemochromatosis and pregnancy: iron stores in the Hfe-/- mouse are not reduced by multiple pregnancies.

Neves JV, Olsson IA, Porto G, Rodrigues PN.

Am J Physiol Gastrointest Liver Physiol. 2010 Apr;298(4):G525-9. doi: 10.1152/ajpgi.00449.2009. Epub 2010 Jan 28.


Altered hepatic BMP signaling pathway in human HFE hemochromatosis.

Bolondi G, Garuti C, Corradini E, Zoller H, Vogel W, Finkenstedt A, Babitt JL, Lin HY, Pietrangelo A.

Blood Cells Mol Dis. 2010 Dec 15;45(4):308-12. doi: 10.1016/j.bcmd.2010.08.010. Epub 2010 Sep 21.


Bmp6 expression in murine liver non parenchymal cells: a mechanism to control their high iron exporter activity and protect hepatocytes from iron overload?

Rausa M, Pagani A, Nai A, Campanella A, Gilberti ME, Apostoli P, Camaschella C, Silvestri L.

PLoS One. 2015 Apr 10;10(4):e0122696. doi: 10.1371/journal.pone.0122696. eCollection 2015 Apr 10.


Differences in activation of mouse hepcidin by dietary iron and parenterally administered iron dextran: compartmentalization is critical for iron sensing.

Daba A, Gkouvatsos K, Sebastiani G, Pantopoulos K.

J Mol Med (Berl). 2013 Jan;91(1):95-102. doi: 10.1007/s00109-012-0937-5. Epub 2012 Jul 31.


Tmprss6 is a genetic modifier of the Hfe-hemochromatosis phenotype in mice.

Finberg KE, Whittlesey RL, Andrews NC.

Blood. 2011 Apr 28;117(17):4590-9. doi: 10.1182/blood-2010-10-315507. Epub 2011 Feb 25.


Hfe and Hjv exhibit overlapping functions for iron signaling to hepcidin.

Kent P, Wilkinson N, Constante M, Fillebeen C, Gkouvatsos K, Wagner J, Buffler M, Becker C, Schümann K, Santos MM, Pantopoulos K.

J Mol Med (Berl). 2015 May;93(5):489-98. doi: 10.1007/s00109-015-1253-7. Epub 2015 Jan 23.


Parenteral vs. oral iron: influence on hepcidin signaling pathways through analysis of Hfe/Tfr2-null mice.

McDonald CJ, Wallace DF, Ostini L, Subramaniam VN.

Am J Physiol Gastrointest Liver Physiol. 2014 Jan;306(2):G132-9. doi: 10.1152/ajpgi.00256.2013. Epub 2013 Nov 27.


Disruption of hemochromatosis protein and transferrin receptor 2 causes iron-induced liver injury in mice.

Delima RD, Chua AC, Tirnitz-Parker JE, Gan EK, Croft KD, Graham RM, Olynyk JK, Trinder D.

Hepatology. 2012 Aug;56(2):585-93. doi: 10.1002/hep.25689. Epub 2012 Jun 11.


Serum and liver iron differently regulate the bone morphogenetic protein 6 (BMP6)-SMAD signaling pathway in mice.

Corradini E, Meynard D, Wu Q, Chen S, Ventura P, Pietrangelo A, Babitt JL.

Hepatology. 2011 Jul;54(1):273-84. doi: 10.1002/hep.24359.


Combined deletion of Hfe and transferrin receptor 2 in mice leads to marked dysregulation of hepcidin and iron overload.

Wallace DF, Summerville L, Crampton EM, Frazer DM, Anderson GJ, Subramaniam VN.

Hepatology. 2009 Dec;50(6):1992-2000. doi: 10.1002/hep.23198.


Smad6 and Smad7 are co-regulated with hepcidin in mouse models of iron overload.

Vujić Spasić M, Sparla R, Mleczko-Sanecka K, Migas MC, Breitkopf-Heinlein K, Dooley S, Vaulont S, Fleming RE, Muckenthaler MU.

Biochim Biophys Acta. 2013 Jan;1832(1):76-84. doi: 10.1016/j.bbadis.2012.08.013. Epub 2012 Aug 31.


Contribution of Hfe expression in macrophages to the regulation of hepatic hepcidin levels and iron loading.

Makui H, Soares RJ, Jiang W, Constante M, Santos MM.

Blood. 2005 Sep 15;106(6):2189-95. Epub 2005 May 24.

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