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Activation of phosphatidylinositol-3'-kinase/AKT signaling is essential in hepatoblastoma survival.

Hartmann W, Küchler J, Koch A, Friedrichs N, Waha A, Endl E, Czerwitzki J, Metzger D, Steiner S, Wurst P, Leuschner I, von Schweinitz D, Buettner R, Pietsch T.

Clin Cancer Res. 2009 Jul 15;15(14):4538-45. doi: 10.1158/1078-0432.CCR-08-2878. Epub 2009 Jul 7.


Phosphatidylinositol-3'-kinase/AKT signaling is essential in synovial sarcoma.

Friedrichs N, Trautmann M, Endl E, Sievers E, Kindler D, Wurst P, Czerwitzki J, Steiner S, Renner M, Penzel R, Koch A, Larsson O, Tanaka S, Kawai A, Schirmacher P, Mechtersheimer G, Wardelmann E, Buettner R, Hartmann W.

Int J Cancer. 2011 Oct 1;129(7):1564-75. doi: 10.1002/ijc.25829. Epub 2011 Mar 4.


Glycogen synthase kinase-3 couples AKT-dependent signaling to the regulation of p21Cip1 degradation.

Rössig L, Badorff C, Holzmann Y, Zeiher AM, Dimmeler S.

J Biol Chem. 2002 Mar 22;277(12):9684-9. Epub 2002 Jan 4.


LY294002 and metformin cooperatively enhance the inhibition of growth and the induction of apoptosis of ovarian cancer cells.

Li C, Liu VW, Chan DW, Yao KM, Ngan HY.

Int J Gynecol Cancer. 2012 Jan;22(1):15-22. doi: 10.1097/IGC.0b013e3182322834.


Inhibition of phosphatidylinositol 3-kinase promotes tumor cell resistance to chemotherapeutic agents via a mechanism involving delay in cell cycle progression.

McDonald GT, Sullivan R, Paré GC, Graham CH.

Exp Cell Res. 2010 Nov 15;316(19):3197-206. doi: 10.1016/j.yexcr.2010.08.007. Epub 2010 Aug 22.


BCR/ABL regulates expression of the cyclin-dependent kinase inhibitor p27Kip1 through the phosphatidylinositol 3-Kinase/AKT pathway.

Gesbert F, Sellers WR, Signoretti S, Loda M, Griffin JD.

J Biol Chem. 2000 Dec 15;275(50):39223-30.


Increased activation of PI3K/AKT signaling pathway is associated with cholangiocarcinoma metastasis and PI3K/mTOR inhibition presents a possible therapeutic strategy.

Yothaisong S, Dokduang H, Techasen A, Namwat N, Yongvanit P, Bhudhisawasdi V, Puapairoj A, Riggins GJ, Loilome W.

Tumour Biol. 2013 Dec;34(6):3637-48. doi: 10.1007/s13277-013-0945-2. Epub 2013 Jul 6.


Longitudinal inhibition of PI3K/Akt/mTOR signaling by LY294002 and rapamycin induces growth arrest of adult T-cell leukemia cells.

Ikezoe T, Nishioka C, Bandobashi K, Yang Y, Kuwayama Y, Adachi Y, Takeuchi T, Koeffler HP, Taguchi H.

Leuk Res. 2007 May;31(5):673-82. Epub 2006 Sep 27.


Synergistic interaction between 17-AAG and phosphatidylinositol 3-kinase inhibition in human malignant glioma cells.

Premkumar DR, Arnold B, Jane EP, Pollack IF.

Mol Carcinog. 2006 Jan;45(1):47-59.


Activation of mammalian target of rapamycin signaling pathway contributes to tumor cell survival in anaplastic lymphoma kinase-positive anaplastic large cell lymphoma.

Vega F, Medeiros LJ, Leventaki V, Atwell C, Cho-Vega JH, Tian L, Claret FX, Rassidakis GZ.

Cancer Res. 2006 Jul 1;66(13):6589-97.


[The relationship of mTOR signaling pathway and histone acetylation in human gastric cancer cell lines].

Sun DF, Fang JY, Zhang YJ, Tian XQ, Zhu HY, Li EL, Gu WQ, Shen GF.

Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2007 Aug;24(4):387-91. Chinese.


Id-1 activation of PI3K/Akt/NFkappaB signaling pathway and its significance in promoting survival of esophageal cancer cells.

Li B, Cheung PY, Wang X, Tsao SW, Ling MT, Wong YC, Cheung AL.

Carcinogenesis. 2007 Nov;28(11):2313-20. Epub 2007 Jul 16.


Phosphatidylinositol 3'-kinase/AKT signaling is activated in medulloblastoma cell proliferation and is associated with reduced expression of PTEN.

Hartmann W, Digon-Söntgerath B, Koch A, Waha A, Endl E, Dani I, Denkhaus D, Goodyer CG, Sörensen N, Wiestler OD, Pietsch T.

Clin Cancer Res. 2006 May 15;12(10):3019-27.


A comprehensive immunohistochemical and molecular approach to the PI3K/AKT/mTOR (phosphoinositide 3-kinase/v-akt murine thymoma viral oncogene/mammalian target of rapamycin) pathway in bladder urothelial carcinoma.

Korkolopoulou P, Levidou G, Trigka EA, Prekete N, Karlou M, Thymara I, Sakellariou S, Fragkou P, Isaiadis D, Pavlopoulos P, Patsouris E, Saetta AA.

BJU Int. 2012 Dec;110(11 Pt C):E1237-48. doi: 10.1111/j.1464-410X.2012.11569.x. Epub 2012 Oct 29.


Inhibition of the PI3K-Akt signaling pathway enhances the sensitivity of Fas-mediated apoptosis in human gastric carcinoma cell line, MKN-45.

Osaki M, Kase S, Adachi K, Takeda A, Hashimoto K, Ito H.

J Cancer Res Clin Oncol. 2004 Jan;130(1):8-14. Epub 2003 Nov 7.


Antitumor activity of ZSTK474, a new phosphatidylinositol 3-kinase inhibitor.

Yaguchi S, Fukui Y, Koshimizu I, Yoshimi H, Matsuno T, Gouda H, Hirono S, Yamazaki K, Yamori T.

J Natl Cancer Inst. 2006 Apr 19;98(8):545-56.


Herceptin-induced inhibition of phosphatidylinositol-3 kinase and Akt Is required for antibody-mediated effects on p27, cyclin D1, and antitumor action.

Yakes FM, Chinratanalab W, Ritter CA, King W, Seelig S, Arteaga CL.

Cancer Res. 2002 Jul 15;62(14):4132-41.

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