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Items: 1 to 20 of 171


Dab2 stabilizes Axin and attenuates Wnt/beta-catenin signaling by preventing protein phosphatase 1 (PP1)-Axin interactions.

Jiang Y, Luo W, Howe PH.

Oncogene. 2009 Aug 20;28(33):2999-3007. doi: 10.1038/onc.2009.157. Epub 2009 Jul 6.


Regulation of the Wnt signaling pathway by disabled-2 (Dab2).

Hocevar BA, Mou F, Rennolds JL, Morris SM, Cooper JA, Howe PH.

EMBO J. 2003 Jun 16;22(12):3084-94.


The inhibitory effects of Disabled-2 (Dab2) on Wnt signaling are mediated through Axin.

Jiang Y, Prunier C, Howe PH.

Oncogene. 2008 Mar 20;27(13):1865-75. Epub 2007 Oct 8.


Protein phosphatase 1 regulates assembly and function of the beta-catenin degradation complex.

Luo W, Peterson A, Garcia BA, Coombs G, Kofahl B, Heinrich R, Shabanowitz J, Hunt DF, Yost HJ, Virshup DM.

EMBO J. 2007 Mar 21;26(6):1511-21. Epub 2007 Feb 22.


LRP6 transduces a canonical Wnt signal independently of Axin degradation by inhibiting GSK3's phosphorylation of beta-catenin.

Cselenyi CS, Jernigan KK, Tahinci E, Thorne CA, Lee LA, Lee E.

Proc Natl Acad Sci U S A. 2008 Jun 10;105(23):8032-7. doi: 10.1073/pnas.0803025105. Epub 2008 May 28.


Initiation of Wnt signaling: control of Wnt coreceptor Lrp6 phosphorylation/activation via frizzled, dishevelled and axin functions.

Zeng X, Huang H, Tamai K, Zhang X, Harada Y, Yokota C, Almeida K, Wang J, Doble B, Woodgett J, Wynshaw-Boris A, Hsieh JC, He X.

Development. 2008 Jan;135(2):367-75. Epub 2007 Dec 12.


Differential role of Axin RGS domain function in Wnt signaling during anteroposterior patterning and maternal axis formation.

Schneider PN, Slusarski DC, Houston DW.

PLoS One. 2012;7(9):e44096. doi: 10.1371/journal.pone.0044096. Epub 2012 Sep 5.


Domains of axin involved in protein-protein interactions, Wnt pathway inhibition, and intracellular localization.

Fagotto F, Jho Eh, Zeng L, Kurth T, Joos T, Kaufmann C, Costantini F.

J Cell Biol. 1999 May 17;145(4):741-56.


Disabled-2 (Dab2) inhibits Wnt/β-catenin signalling by binding LRP6 and promoting its internalization through clathrin.

Jiang Y, He X, Howe PH.

EMBO J. 2012 May 16;31(10):2336-49. doi: 10.1038/emboj.2012.83. Epub 2012 Apr 10.


Identification of zinc-finger BED domain-containing 3 (Zbed3) as a novel Axin-interacting protein that activates Wnt/beta-catenin signaling.

Chen T, Li M, Ding Y, Zhang LS, Xi Y, Pan WJ, Tao DL, Wang JY, Li L.

J Biol Chem. 2009 Mar 13;284(11):6683-9. doi: 10.1074/jbc.M807753200. Epub 2009 Jan 13.


Wnt-induced dephosphorylation of axin releases beta-catenin from the axin complex.

Willert K, Shibamoto S, Nusse R.

Genes Dev. 1999 Jul 15;13(14):1768-73.


A beta-catenin-independent dorsalization pathway activated by Axin/JNK signaling and antagonized by aida.

Rui Y, Xu Z, Xiong B, Cao Y, Lin S, Zhang M, Chan SC, Luo W, Han Y, Lu Z, Ye Z, Zhou HM, Han J, Meng A, Lin SC.

Dev Cell. 2007 Aug;13(2):268-82.


N-cadherin interacts with axin and LRP5 to negatively regulate Wnt/beta-catenin signaling, osteoblast function, and bone formation.

Haÿ E, Laplantine E, Geoffroy V, Frain M, Kohler T, Müller R, Marie PJ.

Mol Cell Biol. 2009 Feb;29(4):953-64. doi: 10.1128/MCB.00349-08. Epub 2008 Dec 15.


A novel Wilms tumor 1 (WT1) target gene negatively regulates the WNT signaling pathway.

Kim MS, Yoon SK, Bollig F, Kitagaki J, Hur W, Whye NJ, Wu YP, Rivera MN, Park JY, Kim HS, Malik K, Bell DW, Englert C, Perantoni AO, Lee SB.

J Biol Chem. 2010 May 7;285(19):14585-93. doi: 10.1074/jbc.M109.094334. Epub 2010 Mar 10.


Smurf1-mediated Lys29-linked nonproteolytic polyubiquitination of axin negatively regulates Wnt/β-catenin signaling.

Fei C, Li Z, Li C, Chen Y, Chen Z, He X, Mao L, Wang X, Zeng R, Li L.

Mol Cell Biol. 2013 Oct;33(20):4095-105. doi: 10.1128/MCB.00418-13. Epub 2013 Aug 19.


Wnt stabilization of β-catenin reveals principles for morphogen receptor-scaffold assemblies.

Kim SE, Huang H, Zhao M, Zhang X, Zhang A, Semonov MV, MacDonald BT, Zhang X, Garcia Abreu J, Peng L, He X.

Science. 2013 May 17;340(6134):867-70. doi: 10.1126/science.1232389. Epub 2013 Apr 11.


Structural and functional characterization of the Wnt inhibitor APC membrane recruitment 1 (Amer1).

Tanneberger K, Pfister AS, Kriz V, Bryja V, Schambony A, Behrens J.

J Biol Chem. 2011 Jun 3;286(22):19204-14. doi: 10.1074/jbc.M111.224881. Epub 2011 Apr 15.


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