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Sac3 is an insulin-regulated phosphatidylinositol 3,5-bisphosphate phosphatase: gain in insulin responsiveness through Sac3 down-regulation in adipocytes.

Ikonomov OC, Sbrissa D, Ijuin T, Takenawa T, Shisheva A.

J Biol Chem. 2009 Sep 4;284(36):23961-71. doi: 10.1074/jbc.M109.025361. Epub 2009 Jul 3.


ArPIKfyve-PIKfyve interaction and role in insulin-regulated GLUT4 translocation and glucose transport in 3T3-L1 adipocytes.

Ikonomov OC, Sbrissa D, Dondapati R, Shisheva A.

Exp Cell Res. 2007 Jul 1;313(11):2404-16. Epub 2007 Mar 30.


PIKfyve-ArPIKfyve-Sac3 core complex: contact sites and their consequence for Sac3 phosphatase activity and endocytic membrane homeostasis.

Ikonomov OC, Sbrissa D, Fenner H, Shisheva A.

J Biol Chem. 2009 Dec 18;284(51):35794-806. doi: 10.1074/jbc.M109.037515.


ArPIKfyve regulates Sac3 protein abundance and turnover: disruption of the mechanism by Sac3I41T mutation causing Charcot-Marie-Tooth 4J disorder.

Ikonomov OC, Sbrissa D, Fligger J, Delvecchio K, Shisheva A.

J Biol Chem. 2010 Aug 27;285(35):26760-4. doi: 10.1074/jbc.C110.154658. Epub 2010 Jul 14.


ArPIKfyve homomeric and heteromeric interactions scaffold PIKfyve and Sac3 in a complex to promote PIKfyve activity and functionality.

Sbrissa D, Ikonomov OC, Fenner H, Shisheva A.

J Mol Biol. 2008 Dec 26;384(4):766-79. doi: 10.1016/j.jmb.2008.10.009. Epub 2008 Oct 11.


The PIKfyve-ArPIKfyve-Sac3 triad in human breast cancer: Functional link between elevated Sac3 phosphatase and enhanced proliferation of triple negative cell lines.

Ikonomov OC, Filios C, Sbrissa D, Chen X, Shisheva A.

Biochem Biophys Res Commun. 2013 Oct 18;440(2):342-7. doi: 10.1016/j.bbrc.2013.09.080. Epub 2013 Sep 23.


Phosphatidylinositol 3-phosphate [PtdIns3P] is generated at the plasma membrane by an inositol polyphosphate 5-phosphatase: endogenous PtdIns3P can promote GLUT4 translocation to the plasma membrane.

Kong AM, Horan KA, Sriratana A, Bailey CG, Collyer LJ, Nandurkar HH, Shisheva A, Layton MJ, Rasko JE, Rowe T, Mitchell CA.

Mol Cell Biol. 2006 Aug;26(16):6065-81.


Role for a novel signaling intermediate, phosphatidylinositol 5-phosphate, in insulin-regulated F-actin stress fiber breakdown and GLUT4 translocation.

Sbrissa D, Ikonomov OC, Strakova J, Shisheva A.

Endocrinology. 2004 Nov;145(11):4853-65. Epub 2004 Jul 29.


An SH2 domain-containing 5' inositolphosphatase inhibits insulin-induced GLUT4 translocation and growth factor-induced actin filament rearrangement.

Vollenweider P, Clodi M, Martin SS, Imamura T, Kavanaugh WM, Olefsky JM.

Mol Cell Biol. 1999 Feb;19(2):1081-91.


YM201636, an inhibitor of retroviral budding and PIKfyve-catalyzed PtdIns(3,5)P2 synthesis, halts glucose entry by insulin in adipocytes.

Ikonomov OC, Sbrissa D, Shisheva A.

Biochem Biophys Res Commun. 2009 May 8;382(3):566-70. doi: 10.1016/j.bbrc.2009.03.063. Epub 2009 Mar 14.


Overexpression of SH2-containing inositol phosphatase 2 results in negative regulation of insulin-induced metabolic actions in 3T3-L1 adipocytes via its 5'-phosphatase catalytic activity.

Wada T, Sasaoka T, Funaki M, Hori H, Murakami S, Ishiki M, Haruta T, Asano T, Ogawa W, Ishihara H, Kobayashi M.

Mol Cell Biol. 2001 Mar;21(5):1633-46.


Functional dissociation between PIKfyve-synthesized PtdIns5P and PtdIns(3,5)P2 by means of the PIKfyve inhibitor YM201636.

Sbrissa D, Ikonomov OC, Filios C, Delvecchio K, Shisheva A.

Am J Physiol Cell Physiol. 2012 Aug 15;303(4):C436-46. doi: 10.1152/ajpcell.00105.2012. Epub 2012 May 23.


The Protein Complex of Neurodegeneration-related Phosphoinositide Phosphatase Sac3 and ArPIKfyve Binds the Lewy Body-associated Synphilin-1, Preventing Its Aggregation.

Ikonomov OC, Sbrissa D, Compton LM, Kumar R, Tisdale EJ, Chen X, Shisheva A.

J Biol Chem. 2015 Nov 20;290(47):28515-29. doi: 10.1074/jbc.M115.669929. Epub 2015 Sep 24.


Regulation of phosphoinositide metabolism, Akt phosphorylation, and glucose transport by PTEN (phosphatase and tensin homolog deleted on chromosome 10) in 3T3-L1 adipocytes.

Ono H, Katagiri H, Funaki M, Anai M, Inukai K, Fukushima Y, Sakoda H, Ogihara T, Onishi Y, Fujishiro M, Kikuchi M, Oka Y, Asano T.

Mol Endocrinol. 2001 Aug;15(8):1411-22.


Expression of myotubularin by an adenoviral vector demonstrates its function as a phosphatidylinositol 3-phosphate [PtdIns(3)P] phosphatase in muscle cell lines: involvement of PtdIns(3)P in insulin-stimulated glucose transport.

Chaussade C, Pirola L, Bonnafous S, Blondeau F, Brenz-Verca S, Tronchère H, Portis F, Rusconi S, Payrastre B, Laporte J, Van Obberghen E.

Mol Endocrinol. 2003 Dec;17(12):2448-60. Epub 2003 Sep 18.


Selective insulin-induced activation of class I(A) phosphoinositide 3-kinase in PIKfyve immune complexes from 3T3-L1 adipocytes.

Sbrissa D, Ikonomov O, Shisheva A.

Mol Cell Endocrinol. 2001 Jul 5;181(1-2):35-46.


PTEN, but not SHIP2, suppresses insulin signaling through the phosphatidylinositol 3-kinase/Akt pathway in 3T3-L1 adipocytes.

Tang X, Powelka AM, Soriano NA, Czech MP, Guilherme A.

J Biol Chem. 2005 Jun 10;280(23):22523-9. Epub 2005 Apr 11.

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