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Items: 1 to 20 of 105


Identification of specific hemopexin-like domain residues that facilitate matrix metalloproteinase collagenolytic activity.

Lauer-Fields JL, Chalmers MJ, Busby SA, Minond D, Griffin PR, Fields GB.

J Biol Chem. 2009 Sep 4;284(36):24017-24. doi: 10.1074/jbc.M109.016873. Epub 2009 Jul 1.


The interface between catalytic and hemopexin domains in matrix metalloproteinase-1 conceals a collagen binding exosite.

Arnold LH, Butt LE, Prior SH, Read CM, Fields GB, Pickford AR.

J Biol Chem. 2011 Dec 30;286(52):45073-82. doi: 10.1074/jbc.M111.285213. Epub 2011 Oct 26.


Structural basis for matrix metalloproteinase 1-catalyzed collagenolysis.

Bertini I, Fragai M, Luchinat C, Melikian M, Toccafondi M, Lauer JL, Fields GB.

J Am Chem Soc. 2012 Feb 1;134(4):2100-10. doi: 10.1021/ja208338j. Epub 2012 Jan 19.


Structural insights into triple-helical collagen cleavage by matrix metalloproteinase 1.

Manka SW, Carafoli F, Visse R, Bihan D, Raynal N, Farndale RW, Murphy G, Enghild JJ, Hohenester E, Nagase H.

Proc Natl Acad Sci U S A. 2012 Jul 31;109(31):12461-6. doi: 10.1073/pnas.1204991109. Epub 2012 Jul 3.


Biophysical studies of matrix metalloproteinase/triple-helix complexes.

Fields GB.

Adv Protein Chem Struct Biol. 2014;97:37-48. doi: 10.1016/bs.apcsb.2014.09.001. Epub 2014 Nov 7. Review.


Collagenolytic Matrix Metalloproteinase Activities toward Peptomeric Triple-Helical Substrates.

Stawikowski MJ, Stawikowska R, Fields GB.

Biochemistry. 2015 May 19;54(19):3110-21. doi: 10.1021/acs.biochem.5b00110. Epub 2015 May 5.


Matrix metalloproteinases and collagen catabolism.

Lauer-Fields JL, Juska D, Fields GB.

Biopolymers. 2002;66(1):19-32. Review.


Collagenolytic Matrix Metalloproteinase Structure-Function Relationships: Insights From Molecular Dynamics Studies.

Karabencheva-Christova TG, Christov CZ, Fields GB.

Adv Protein Chem Struct Biol. 2017;109:1-24. doi: 10.1016/bs.apcsb.2017.04.001. Epub 2017 May 8.


Differentiation of secreted and membrane-type matrix metalloproteinase activities based on substitutions and interruptions of triple-helical sequences.

Minond D, Lauer-Fields JL, Cudic M, Overall CM, Pei D, Brew K, Moss ML, Fields GB.

Biochemistry. 2007 Mar 27;46(12):3724-33. Epub 2007 Mar 6.


Kinetic analysis of matrix metalloproteinase activity using fluorogenic triple-helical substrates.

Lauer-Fields JL, Broder T, Sritharan T, Chung L, Nagase H, Fields GB.

Biochemistry. 2001 May 15;40(19):5795-803.


The roles of substrate thermal stability and P2 and P1' subsite identity on matrix metalloproteinase triple-helical peptidase activity and collagen specificity.

Minond D, Lauer-Fields JL, Cudic M, Overall CM, Pei D, Brew K, Visse R, Nagase H, Fields GB.

J Biol Chem. 2006 Dec 15;281(50):38302-13. Epub 2006 Oct 25.


Identification of the (183)RWTNNFREY(191) region as a critical segment of matrix metalloproteinase 1 for the expression of collagenolytic activity.

Chung L, Shimokawa K, Dinakarpandian D, Grams F, Fields GB, Nagase H.

J Biol Chem. 2000 Sep 22;275(38):29610-7.


Examination of matrix metalloproteinase-1 in solution: a preference for the pre-collagenolysis state.

Cerofolini L, Fields GB, Fragai M, Geraldes CF, Luchinat C, Parigi G, Ravera E, Svergun DI, Teixeira JM.

J Biol Chem. 2013 Oct 18;288(42):30659-71. doi: 10.1074/jbc.M113.477240. Epub 2013 Sep 11.


Collagenase unwinds triple-helical collagen prior to peptide bond hydrolysis.

Chung L, Dinakarpandian D, Yoshida N, Lauer-Fields JL, Fields GB, Visse R, Nagase H.

EMBO J. 2004 Aug 4;23(15):3020-30. Epub 2004 Jul 15.


Matrix metalloproteinase-1 takes advantage of the induced fit mechanism to cleave the triple-helical type I collagen molecule.

O'Farrell TJ, Guo R, Hasegawa H, Pourmotabbed T.

Biochemistry. 2006 Dec 26;45(51):15411-8.


Effects of Mutations on Structure-Function Relationships of Matrix Metalloproteinase-1.

Singh W, Fields GB, Christov CZ, Karabencheva-Christova TG.

Int J Mol Sci. 2016 Oct 14;17(10). pii: E1727.


Selective hydrolysis of triple-helical substrates by matrix metalloproteinase-2 and -9.

Lauer-Fields JL, Sritharan T, Stack MS, Nagase H, Fields GB.

J Biol Chem. 2003 May 16;278(20):18140-5. Epub 2003 Mar 17.


The role of collagen charge clusters in the modulation of matrix metalloproteinase activity.

Lauer JL, Bhowmick M, Tokmina-Roszyk D, Lin Y, Van Doren SR, Fields GB.

J Biol Chem. 2014 Jan 24;289(4):1981-92. doi: 10.1074/jbc.M113.513408. Epub 2013 Dec 2.


Interstitial collagen catabolism.

Fields GB.

J Biol Chem. 2013 Mar 29;288(13):8785-93. doi: 10.1074/jbc.R113.451211. Epub 2013 Feb 19. Review.

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