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Items: 1 to 20 of 142

1.

Regulation of basal and reserve cardiac pacemaker function by interactions of cAMP-mediated PKA-dependent Ca2+ cycling with surface membrane channels.

Vinogradova TM, Lakatta EG.

J Mol Cell Cardiol. 2009 Oct;47(4):456-74. doi: 10.1016/j.yjmcc.2009.06.014. Epub 2009 Jun 30. Review.

2.

High basal protein kinase A-dependent phosphorylation drives rhythmic internal Ca2+ store oscillations and spontaneous beating of cardiac pacemaker cells.

Vinogradova TM, Lyashkov AE, Zhu W, Ruknudin AM, Sirenko S, Yang D, Deo S, Barlow M, Johnson S, Caffrey JL, Zhou YY, Xiao RP, Cheng H, Stern MD, Maltsev VA, Lakatta EG.

Circ Res. 2006 Mar 3;98(4):505-14. Epub 2006 Jan 19.

3.

A full range of mouse sinoatrial node AP firing rates requires protein kinase A-dependent calcium signaling.

Liu J, Sirenko S, Juhaszova M, Ziman B, Shetty V, Rain S, Shukla S, Spurgeon HA, Vinogradova TM, Maltsev VA, Lakatta EG.

J Mol Cell Cardiol. 2011 Nov;51(5):730-9. doi: 10.1016/j.yjmcc.2011.07.028. Epub 2011 Aug 4.

4.

Sarcoplasmic reticulum Ca2+ cycling protein phosphorylation in a physiologic Ca2+ milieu unleashes a high-power, rhythmic Ca2+ clock in ventricular myocytes: relevance to arrhythmias and bio-pacemaker design.

Sirenko S, Maltsev VA, Maltseva LA, Yang D, Lukyanenko Y, Vinogradova TM, Jones LR, Lakatta EG.

J Mol Cell Cardiol. 2014 Jan;66:106-15. doi: 10.1016/j.yjmcc.2013.11.011. Epub 2013 Nov 22.

5.

Constitutive phosphodiesterase activity restricts spontaneous beating rate of cardiac pacemaker cells by suppressing local Ca2+ releases.

Vinogradova TM, Sirenko S, Lyashkov AE, Younes A, Li Y, Zhu W, Yang D, Ruknudin AM, Spurgeon H, Lakatta EG.

Circ Res. 2008 Apr 11;102(7):761-9. doi: 10.1161/CIRCRESAHA.107.161679. Epub 2008 Feb 14.

6.

Ca(2+) -stimulated basal adenylyl cyclase activity localization in membrane lipid microdomains of cardiac sinoatrial nodal pacemaker cells.

Younes A, Lyashkov AE, Graham D, Sheydina A, Volkova MV, Mitsak M, Vinogradova TM, Lukyanenko YO, Li Y, Ruknudin AM, Boheler KR, van Eyk J, Lakatta EG.

J Biol Chem. 2008 May 23;283(21):14461-8. doi: 10.1074/jbc.M707540200. Epub 2008 Mar 20.

7.

Ca2+-regulated-cAMP/PKA signaling in cardiac pacemaker cells links ATP supply to demand.

Yaniv Y, Juhaszova M, Lyashkov AE, Spurgeon HA, Sollott SJ, Lakatta EG.

J Mol Cell Cardiol. 2011 Nov;51(5):740-8. doi: 10.1016/j.yjmcc.2011.07.018. Epub 2011 Jul 28.

8.

CaMKII-dependent phosphorylation regulates basal cardiac pacemaker function via modulation of local Ca2+ releases.

Li Y, Sirenko S, Riordon DR, Yang D, Spurgeon H, Lakatta EG, Vinogradova TM.

Am J Physiol Heart Circ Physiol. 2016 Sep 1;311(3):H532-44. doi: 10.1152/ajpheart.00765.2015. Epub 2016 Jul 8.

9.

Cholinergic receptor signaling modulates spontaneous firing of sinoatrial nodal cells via integrated effects on PKA-dependent Ca(2+) cycling and I(KACh).

Lyashkov AE, Vinogradova TM, Zahanich I, Li Y, Younes A, Nuss HB, Spurgeon HA, Maltsev VA, Lakatta EG.

Am J Physiol Heart Circ Physiol. 2009 Sep;297(3):H949-59. doi: 10.1152/ajpheart.01340.2008. Epub 2009 Jun 19.

10.

Sarcoplasmic reticulum Ca2+ pumping kinetics regulates timing of local Ca2+ releases and spontaneous beating rate of rabbit sinoatrial node pacemaker cells.

Vinogradova TM, Brochet DX, Sirenko S, Li Y, Spurgeon H, Lakatta EG.

Circ Res. 2010 Sep 17;107(6):767-75. doi: 10.1161/CIRCRESAHA.110.220517. Epub 2010 Jul 22.

11.

Ca²⁺-dependent phosphorylation of Ca²⁺ cycling proteins generates robust rhythmic local Ca²⁺ releases in cardiac pacemaker cells.

Sirenko S, Yang D, Li Y, Lyashkov AE, Lukyanenko YO, Lakatta EG, Vinogradova TM.

Sci Signal. 2013 Jan 29;6(260):ra6. doi: 10.1126/scisignal.2003391.

12.

Rhythmic Ca2+ oscillations drive sinoatrial nodal cell pacemaker function to make the heart tick.

Vinogradova TM, Maltsev VA, Bogdanov KY, Lyashkov AE, Lakatta EG.

Ann N Y Acad Sci. 2005 Jun;1047:138-56. Review.

PMID:
16093492
13.

Synergism of coupled subsarcolemmal Ca2+ clocks and sarcolemmal voltage clocks confers robust and flexible pacemaker function in a novel pacemaker cell model.

Maltsev VA, Lakatta EG.

Am J Physiol Heart Circ Physiol. 2009 Mar;296(3):H594-615. doi: 10.1152/ajpheart.01118.2008. Epub 2009 Jan 9.

14.

Ca(2+)/calmodulin-activated phosphodiesterase 1A is highly expressed in rabbit cardiac sinoatrial nodal cells and regulates pacemaker function.

Lukyanenko YO, Younes A, Lyashkov AE, Tarasov KV, Riordon DR, Lee J, Sirenko SG, Kobrinsky E, Ziman B, Tarasova YS, Juhaszova M, Sollott SJ, Graham DR, Lakatta EG.

J Mol Cell Cardiol. 2016 Sep;98:73-82. doi: 10.1016/j.yjmcc.2016.06.064. Epub 2016 Jun 27.

15.

Dynamics of PKA phosphorylation and gain of function in cardiac pacemaker cells: a computational model analysis.

Behar J, Yaniv Y.

Am J Physiol Heart Circ Physiol. 2016 May 1;310(9):H1259-66. doi: 10.1152/ajpheart.00076.2016. Epub 2016 Mar 4.

17.

New evidence for coupled clock regulation of the normal automaticity of sinoatrial nodal pacemaker cells: bradycardic effects of ivabradine are linked to suppression of intracellular Ca²⁺ cycling.

Yaniv Y, Sirenko S, Ziman BD, Spurgeon HA, Maltsev VA, Lakatta EG.

J Mol Cell Cardiol. 2013 Sep;62:80-9. doi: 10.1016/j.yjmcc.2013.04.026. Epub 2013 May 5.

18.

Age-associated abnormalities of intrinsic automaticity of sinoatrial nodal cells are linked to deficient cAMP-PKA-Ca(2+) signaling.

Liu J, Sirenko S, Juhaszova M, Sollott SJ, Shukla S, Yaniv Y, Lakatta EG.

Am J Physiol Heart Circ Physiol. 2014 May 15;306(10):H1385-97. doi: 10.1152/ajpheart.00088.2014. Epub 2014 Mar 14. Erratum in: Am J Physiol Heart Circ Physiol. 2014 Jul 1;307(1):H118-9.

19.

A coupled SYSTEM of intracellular Ca2+ clocks and surface membrane voltage clocks controls the timekeeping mechanism of the heart's pacemaker.

Lakatta EG, Maltsev VA, Vinogradova TM.

Circ Res. 2010 Mar 5;106(4):659-73. doi: 10.1161/CIRCRESAHA.109.206078. Review.

20.

Real-time relationship between PKA biochemical signal network dynamics and increased action potential firing rate in heart pacemaker cells: Kinetics of PKA activation in heart pacemaker cells.

Yaniv Y, Ganesan A, Yang D, Ziman BD, Lyashkov AE, Levchenko A, Zhang J, Lakatta EG.

J Mol Cell Cardiol. 2015 Sep;86:168-78. doi: 10.1016/j.yjmcc.2015.07.024. Epub 2015 Aug 1.

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