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Items: 1 to 20 of 109

1.

Mechanism of PDK1-catalyzed Thr-229 phosphorylation of the S6K1 protein kinase.

Keshwani MM, Gao X, Harris TK.

J Biol Chem. 2009 Aug 21;284(34):22611-24. doi: 10.1074/jbc.M109.032177. Epub 2009 Jul 1.

2.

Characterization of phosphatidylinositol 3-kinase-dependent phosphorylation of the hydrophobic motif site Thr(389) in p70 S6 kinase 1.

Romanelli A, Dreisbach VC, Blenis J.

J Biol Chem. 2002 Oct 25;277(43):40281-9. Epub 2002 Aug 14.

3.

Steady-state kinetic mechanism of PDK1.

Gao X, Harris TK.

J Biol Chem. 2006 Aug 4;281(31):21670-81. Epub 2006 May 31.

4.

Kinetic mechanism of fully activated S6K1 protein kinase.

Keshwani MM, Harris TK.

J Biol Chem. 2008 May 2;283(18):11972-80. doi: 10.1074/jbc.M800114200. Epub 2008 Mar 6.

5.

Evidence that 3-phosphoinositide-dependent protein kinase-1 mediates phosphorylation of p70 S6 kinase in vivo at Thr-412 as well as Thr-252.

Balendran A, Currie R, Armstrong CG, Avruch J, Alessi DR.

J Biol Chem. 1999 Dec 24;274(52):37400-6.

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3-Phosphoinositide-dependent protein kinase 1 (PDK1) phosphorylates and activates the p70 S6 kinase in vivo and in vitro.

Alessi DR, Kozlowski MT, Weng QP, Morrice N, Avruch J.

Curr Biol. 1998 Jan 15;8(2):69-81.

8.

Regulation of an activated S6 kinase 1 variant reveals a novel mammalian target of rapamycin phosphorylation site.

Saitoh M, Pullen N, Brennan P, Cantrell D, Dennis PB, Thomas G.

J Biol Chem. 2002 May 31;277(22):20104-12. Epub 2002 Mar 25.

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10.

Hydrophobic motif phosphorylation is not required for activation loop phosphorylation of p70 ribosomal protein S6 kinase 1 (S6K1).

Keshwani MM, von Daake S, Newton AC, Harris TK, Taylor SS.

J Biol Chem. 2011 Jul 1;286(26):23552-8. doi: 10.1074/jbc.M111.258004. Epub 2011 May 11.

12.

The role of 3-phosphoinositide-dependent protein kinase 1 in activating AGC kinases defined in embryonic stem cells.

Williams MR, Arthur JS, Balendran A, van der Kaay J, Poli V, Cohen P, Alessi DR.

Curr Biol. 2000 Apr 20;10(8):439-48.

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14.

c-Raf/MEK/ERK pathway controls protein kinase C-mediated p70S6K activation in adult cardiac muscle cells.

Iijima Y, Laser M, Shiraishi H, Willey CD, Sundaravadivel B, Xu L, McDermott PJ, Kuppuswamy D.

J Biol Chem. 2002 Jun 21;277(25):23065-75. Epub 2002 Apr 8.

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The PIF-binding pocket in PDK1 is essential for activation of S6K and SGK, but not PKB.

Biondi RM, Kieloch A, Currie RA, Deak M, Alessi DR.

EMBO J. 2001 Aug 15;20(16):4380-90.

19.

A phosphoserine-regulated docking site in the protein kinase RSK2 that recruits and activates PDK1.

Frödin M, Jensen CJ, Merienne K, Gammeltoft S.

EMBO J. 2000 Jun 15;19(12):2924-34.

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