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Sterol regulatory element binding protein 1a regulates hepatic fatty acid partitioning by activating acetyl coenzyme A carboxylase 2.

Im SS, Hammond LE, Yousef L, Nugas-Selby C, Shin DJ, Seo YK, Fong LG, Young SG, Osborne TF.

Mol Cell Biol. 2009 Sep;29(17):4864-72. doi: 10.1128/MCB.00553-09. Epub 2009 Jun 29. Erratum in: Mol Cell Biol. 2009 Nov;29(21):5974.


Isoform 1c of sterol regulatory element binding protein is less active than isoform 1a in livers of transgenic mice and in cultured cells.

Shimano H, Horton JD, Shimomura I, Hammer RE, Brown MS, Goldstein JL.

J Clin Invest. 1997 Mar 1;99(5):846-54.


Diminished hepatic response to fasting/refeeding and liver X receptor agonists in mice with selective deficiency of sterol regulatory element-binding protein-1c.

Liang G, Yang J, Horton JD, Hammer RE, Goldstein JL, Brown MS.

J Biol Chem. 2002 Mar 15;277(11):9520-8. Epub 2002 Jan 8.


Sterol regulatory element-binding protein-1 as a key transcription factor for nutritional induction of lipogenic enzyme genes.

Shimano H, Yahagi N, Amemiya-Kudo M, Hasty AH, Osuga J, Tamura Y, Shionoiri F, Iizuka Y, Ohashi K, Harada K, Gotoda T, Ishibashi S, Yamada N.

J Biol Chem. 1999 Dec 10;274(50):35832-9.


Overexpression of sterol regulatory element-binding protein-1a in mouse adipose tissue produces adipocyte hypertrophy, increased fatty acid secretion, and fatty liver.

Horton JD, Shimomura I, Ikemoto S, Bashmakov Y, Hammer RE.

J Biol Chem. 2003 Sep 19;278(38):36652-60. Epub 2003 Jul 10.


Modulation of hepatic sterol regulatory element-binding protein-1c-mediated gene expression contributes to Salacia oblonga root-elicited improvement of fructose-induced fatty liver in rats.

Liu L, Yang M, Lin X, Li Y, Liu C, Yang Y, Yamahara J, Wang J, Li Y.

J Ethnopharmacol. 2013 Dec 12;150(3):1045-52. doi: 10.1016/j.jep.2013.10.020. Epub 2013 Oct 21.


5-cholesten-3β,25-diol 3-sulfate decreases lipid accumulation in diet-induced nonalcoholic fatty liver disease mouse model.

Xu L, Kim JK, Bai Q, Zhang X, Kakiyama G, Min HK, Sanyal AJ, Pandak WM, Ren S.

Mol Pharmacol. 2013 Mar;83(3):648-58. doi: 10.1124/mol.112.081505. Epub 2012 Dec 20.


Endoplasmic reticulum stress is involved in hepatic SREBP-1c activation and lipid accumulation in fructose-fed mice.

Zhang C, Chen X, Zhu RM, Zhang Y, Yu T, Wang H, Zhao H, Zhao M, Ji YL, Chen YH, Meng XH, Wei W, Xu DX.

Toxicol Lett. 2012 Aug 3;212(3):229-40. doi: 10.1016/j.toxlet.2012.06.002. Epub 2012 Jun 12.


Promoter analysis of the mouse sterol regulatory element-binding protein-1c gene.

Amemiya-Kudo M, Shimano H, Yoshikawa T, Yahagi N, Hasty AH, Okazaki H, Tamura Y, Shionoiri F, Iizuka Y, Ohashi K, Osuga J, Harada K, Gotoda T, Sato R, Kimura S, Ishibashi S, Yamada N.

J Biol Chem. 2000 Oct 6;275(40):31078-85.


Hepatic glucokinase is required for the synergistic action of ChREBP and SREBP-1c on glycolytic and lipogenic gene expression.

Dentin R, Pégorier JP, Benhamed F, Foufelle F, Ferré P, Fauveau V, Magnuson MA, Girard J, Postic C.

J Biol Chem. 2004 May 7;279(19):20314-26. Epub 2004 Feb 25.


Hepatic differentiated embryo-chondrocyte-expressed gene 1 (Dec1) inhibits sterol regulatory element-binding protein-1c (Srebp-1c) expression and alleviates fatty liver phenotype.

Shen L, Cui A, Xue Y, Cui Y, Dong X, Gao Y, Yang H, Fang F, Chang Y.

J Biol Chem. 2014 Aug 22;289(34):23332-42. doi: 10.1074/jbc.M113.526343. Epub 2014 Jul 3.


Sterol regulatory element binding protein (SREBP)-1 expression in brain is affected by age but not by hormones or metabolic changes.

Okamoto K, Kakuma T, Fukuchi S, Masaki T, Sakata T, Yoshimatsu H.

Brain Res. 2006 Apr 7;1081(1):19-27. Epub 2006 Mar 22.


Fatty acid flux suppresses fatty acid synthesis in hamster intestine independently of SREBP-1 expression.

Field FJ, Born E, Mathur SN.

J Lipid Res. 2003 Jun;44(6):1199-208. Epub 2003 Mar 16.


Microarray analyses of SREBP-1a and SREBP-1c target genes identify new regulatory pathways in muscle.

Rome S, Lecomte V, Meugnier E, Rieusset J, Debard C, Euthine V, Vidal H, Lefai E.

Physiol Genomics. 2008 Aug 15;34(3):327-37. doi: 10.1152/physiolgenomics.90211.2008. Epub 2008 Jun 17.


Selective association of sterol regulatory element-binding protein isoforms with target promoters in vivo.

Bennett MK, Toth JI, Osborne TF.

J Biol Chem. 2004 Sep 3;279(36):37360-7. Epub 2004 Jun 25.


Increased dietary fat contributes to dysregulation of the LKB1/AMPK pathway and increased damage in a mouse model of early-stage ethanol-mediated steatosis.

Shearn CT, Smathers RL, Jiang H, Orlicky DJ, Maclean KN, Petersen DR.

J Nutr Biochem. 2013 Aug;24(8):1436-45. doi: 10.1016/j.jnutbio.2012.12.002. Epub 2013 Mar 1.


Acetyl-CoA carboxylase beta gene is regulated by sterol regulatory element-binding protein-1 in liver.

Oh SY, Park SK, Kim JW, Ahn YH, Park SW, Kim KS.

J Biol Chem. 2003 Aug 1;278(31):28410-7. Epub 2003 May 21.

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