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Items: 1 to 20 of 107


Identification and characterization of novel tissue-nonspecific alkaline phosphatase inhibitors with diverse modes of action.

Sergienko E, Su Y, Chan X, Brown B, Hurder A, Narisawa S, Millán JL.

J Biomol Screen. 2009 Aug;14(7):824-37. doi: 10.1177/1087057109338517. Epub 2009 Jun 25.


High-throughput screening of tissue-nonspecific alkaline phosphatase for identification of effectors with diverse modes of action.

Sergienko EA, Millán JL.

Nat Protoc. 2010 Aug;5(8):1431-9. doi: 10.1038/nprot.2010.86. Epub 2010 Jul 15.


Modulators of intestinal alkaline phosphatase.

Bobkova EV, Kiffer-Moreira T, Sergienko EA.

Methods Mol Biol. 2013;1053:135-44. doi: 10.1007/978-1-62703-562-0_9.


A method for direct assessment of tissue-nonspecific alkaline phosphatase (TNAP) inhibitors in blood samples.

Sergienko EA, Sun Q, Ma CT.

Methods Mol Biol. 2013;1053:103-13. doi: 10.1007/978-1-62703-562-0_6.


Inhibitors of tissue-nonspecific alkaline phosphatase (TNAP): from hits to leads.

Teriete P, Pinkerton AB, Cosford ND.

Methods Mol Biol. 2013;1053:85-101. doi: 10.1007/978-1-62703-562-0_5.


Discovery and validation of a series of aryl sulfonamides as selective inhibitors of tissue-nonspecific alkaline phosphatase (TNAP).

Dahl R, Sergienko EA, Su Y, Mostofi YS, Yang L, Simao AM, Narisawa S, Brown B, Mangravita-Novo A, Vicchiarelli M, Smith LH, O'Neill WC, Millán JL, Cosford ND.

J Med Chem. 2009 Nov 12;52(21):6919-25. doi: 10.1021/jm900383s.


Design and synthesis of pyrazole derivatives as potent and selective inhibitors of tissue-nonspecific alkaline phosphatase (TNAP).

Sidique S, Ardecky R, Su Y, Narisawa S, Brown B, Millán JL, Sergienko E, Cosford ND.

Bioorg Med Chem Lett. 2009 Jan 1;19(1):222-5. doi: 10.1016/j.bmcl.2008.10.107. Epub 2008 Oct 31.


The use of tissue-nonspecific alkaline phosphatase (TNAP) and PHOSPHO1 inhibitors to affect mineralization by cultured cells.

Kiffer-Moreira T, Narisawa S.

Methods Mol Biol. 2013;1053:125-34. doi: 10.1007/978-1-62703-562-0_8.


Isonicotinohydrazones as inhibitors of alkaline phosphatase and ecto-5'-nucleotidase.

Channar PA, Shah SJ, Hassan S, Nisa ZU, Lecka J, Sévigny J, Bajorath J, Saeed A, Iqbal J.

Chem Biol Drug Des. 2017 Mar;89(3):365-370. doi: 10.1111/cbdd.12861. Epub 2016 Oct 26.


Identification of a selective inhibitor of murine intestinal alkaline phosphatase (ML260) by concurrent ultra-high throughput screening against human and mouse isozymes.

Ardecky RJ, Bobkova EV, Kiffer-Moreira T, Brown B, Ganji S, Zou J, Pass I, Narisawa S, Iano FG, Rosenstein C, Cheltsov A, Rascon J, Hedrick M, Gasior C, Forster A, Shi S, Dahl R, Vasile S, Su Y, Sergienko E, Chung TD, Kaunitz J, Hoylaerts MF, Pinkerton AB, Millán JL.

Bioorg Med Chem Lett. 2014 Feb 1;24(3):1000-4. doi: 10.1016/j.bmcl.2013.12.043. Epub 2013 Dec 19.


Substrate selection influences molecular recognition in a screen for lymphoid tyrosine phosphatase inhibitors.

Kulkarni RA, Vellore NA, Bliss MR, Stanford SM, Falk MD, Bottini N, Baron R, Barrios AM.

Chembiochem. 2013 Sep 2;14(13):1640-7. doi: 10.1002/cbic.201300273. Epub 2013 Aug 16.


Discovery of bile salt hydrolase inhibitors using an efficient high-throughput screening system.

Smith K, Zeng X, Lin J.

PLoS One. 2014 Jan 14;9(1):e85344. doi: 10.1371/journal.pone.0085344. eCollection 2014.


Cdc25B dual-specificity phosphatase inhibitors identified in a high-throughput screen of the NIH compound library.

Johnston PA, Foster CA, Tierno MB, Shun TY, Shinde SN, Paquette WD, Brummond KM, Wipf P, Lazo JS.

Assay Drug Dev Technol. 2009 Jun;7(3):250-65. doi: 10.1089/adt.2008.186.


A Selective Murine Intestinal Alkaline Phosphatase (muIAP) Inhibitor.

Ganji S, Zou J, Brown B, Bobkova EV, Ardecky R, Rosenstein C, Pass I, Dahl R, Vasile S, Sergienko E, Shi S, Stonich D, Cheltov A, Su Y, Mangravita-Novo A, Vicchiarelli M, McAnally D, Kim S, Nguyen H, Moreira TK, Smith LH, Zeng FY, Diwan J, Chung TDY, Pinkerton AB, Kaunitz J, Millán JL.

Probe Reports from the NIH Molecular Libraries Program [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2010-.
2011 Oct 31 [updated 2013 Mar 7].


Development and implementation of a miniaturized high-throughput time-resolved fluorescence energy transfer assay to identify small molecule inhibitors of polo-like kinase 1.

Sharlow ER, Leimgruber S, Shun TY, Lazo JS.

Assay Drug Dev Technol. 2007 Dec;5(6):723-35. doi: 10.1089/adt.2007.102.


Novel inhibitors of alkaline phosphatase suppress vascular smooth muscle cell calcification.

Narisawa S, Harmey D, Yadav MC, O'Neill WC, Hoylaerts MF, Millán JL.

J Bone Miner Res. 2007 Nov;22(11):1700-10.


Identification of selective enzyme inhibitors by fragment library screening.

Gao G, Liu X, Pavlovsky A, Viola RE.

J Biomol Screen. 2010 Oct;15(9):1042-50. doi: 10.1177/1087057110381383. Epub 2010 Sep 20.


Synthesis and evaluation of benzo[b]thiophene derivatives as inhibitors of alkaline phosphatases.

Li L, Chang L, Pellet-Rostaing S, Liger F, Lemaire M, Buchet R, Wu Y.

Bioorg Med Chem. 2009 Oct 15;17(20):7290-300. doi: 10.1016/j.bmc.2009.08.048. Epub 2009 Sep 3.


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