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The hedgehog pathway transcription factor GLI1 promotes malignant behavior of cancer cells by up-regulating osteopontin.

Das S, Harris LG, Metge BJ, Liu S, Riker AI, Samant RS, Shevde LA.

J Biol Chem. 2009 Aug 21;284(34):22888-97. doi: 10.1074/jbc.M109.021949. Epub 2009 Jun 25.


Effects of inhibition of hedgehog signaling on cell growth and migration of uveal melanoma cells.

Duan F, Lin M, Li C, Ding X, Qian G, Zhang H, Ge S, Fan X, Li J.

Cancer Biol Ther. 2014 May;15(5):544-59. doi: 10.4161/cbt.28157. Epub 2014 Mar 11.


LKB1 inhibits breast cancer partially through repressing the Hedgehog signaling pathway.

Zhuang Z, Wang K, Cheng X, Qu X, Jiang B, Li Z, Luo J, Shao Z, Duan T.

PLoS One. 2013 Jul 4;8(7):e67431. doi: 10.1371/journal.pone.0067431. Print 2013.


Hedgehog/Gli supports androgen signaling in androgen deprived and androgen independent prostate cancer cells.

Chen M, Feuerstein MA, Levina E, Baghel PS, Carkner RD, Tanner MJ, Shtutman M, Vacherot F, Terry S, de la Taille A, Buttyan R.

Mol Cancer. 2010 Apr 26;9:89. doi: 10.1186/1476-4598-9-89.


Targeting the hedgehog signal transduction pathway at the level of GLI inhibits neuroblastoma cell growth in vitro and in vivo.

Wickström M, Dyberg C, Shimokawa T, Milosevic J, Baryawno N, Fuskevåg OM, Larsson R, Kogner P, Zaphiropoulos PG, Johnsen JI.

Int J Cancer. 2013 Apr 1;132(7):1516-24. doi: 10.1002/ijc.27820. Epub 2012 Oct 3.


Hedgehog signaling in small-cell lung cancer: frequent in vivo but a rare event in vitro.

Vestergaard J, Pedersen MW, Pedersen N, Ensinger C, Tümer Z, Tommerup N, Poulsen HS, Larsen LA.

Lung Cancer. 2006 Jun;52(3):281-90. Epub 2006 Apr 17.


Sonic Hedgehog-GLI Family Zinc Finger 1 Signaling Pathway Promotes the Growth and Migration of Pancreatic Cancer Cells by Regulating the Transcription of Eukaryotic Translation Initiation Factor 5A2.

Xu X, Liu H, Zhang H, Dai W, Guo C, Xie C, Wei S, He S, Xu X.

Pancreas. 2015 Nov;44(8):1252-8. doi: 10.1097/MPA.0000000000000532.


Cyclopamine blocked the growth of colorectal cancer SW116 cells by modulating some target genes of Gli1 in vitro.

Wu JY, Xu XF, Xu L, Niu PQ, Wang F, Hu GY, Wang XP, Guo CY.

Hepatogastroenterology. 2011 Sep-Oct;58(110-111):1511-8. doi: 10.5754/hge10765. Epub 2011 Jul 15.


Nonclassical activation of Hedgehog signaling enhances multidrug resistance and makes cancer cells refractory to Smoothened-targeting Hedgehog inhibition.

Das S, Samant RS, Shevde LA.

J Biol Chem. 2013 Apr 26;288(17):11824-33. doi: 10.1074/jbc.M112.432302. Epub 2013 Mar 18.


Inhibition of Hedgehog signaling antagonizes serous ovarian cancer growth in a primary xenograft model.

McCann CK, Growdon WB, Kulkarni-Datar K, Curley MD, Friel AM, Proctor JL, Sheikh H, Deyneko I, Ferguson JA, Vathipadiekal V, Birrer MJ, Borger DR, Mohapatra G, Zukerberg LR, Foster R, Macdougall JR, Rueda BR.

PLoS One. 2011;6(11):e28077. doi: 10.1371/journal.pone.0028077. Epub 2011 Nov 29.


Gli-1 expression is associated with lymph node metastasis and tumor progression in esophageal squamous cell carcinoma.

Mori Y, Okumura T, Tsunoda S, Sakai Y, Shimada Y.

Oncology. 2006;70(5):378-89. Epub 2006 Dec 15.


Hedgehog signaling pathway is inactive in colorectal cancer cell lines.

Chatel G, Ganeff C, Boussif N, Delacroix L, Briquet A, Nolens G, Winkler R.

Int J Cancer. 2007 Dec 15;121(12):2622-7.


Hedgehog-signaling is upregulated in non-producing human adrenal adenomas and antagonism of hedgehog-signaling inhibits proliferation of NCI-H295R cells and an immortalized primary human adrenal cell line.

Werminghaus P, Haase M, Hornsby PJ, Schinner S, Schott M, Malendowicz LK, Lammers BJ, Goretzki PE, Müller-Mattheis V, Markus Giessing, Willenberg HS.

J Steroid Biochem Mol Biol. 2014 Jan;139:7-15. doi: 10.1016/j.jsbmb.2013.09.007. Epub 2013 Sep 21.


Role of hedgehog signaling in malignant pleural mesothelioma.

Shi Y, Moura U, Opitz I, Soltermann A, Rehrauer H, Thies S, Weder W, Stahel RA, Felley-Bosco E.

Clin Cancer Res. 2012 Sep 1;18(17):4646-56. doi: 10.1158/1078-0432.CCR-12-0599. Epub 2012 Jun 25.


Noncanonical regulation of the Hedgehog mediator GLI1 by c-MYC in Burkitt lymphoma.

Yoon JW, Gallant M, Lamm ML, Iannaccone S, Vieux KF, Proytcheva M, Hyjek E, Iannaccone P, Walterhouse D.

Mol Cancer Res. 2013 Jun;11(6):604-15. doi: 10.1158/1541-7786.MCR-12-0441. Epub 2013 Mar 22.


The functional -443T/C osteopontin promoter polymorphism influences osteopontin gene expression in melanoma cells via binding of c-Myb transcription factor.

Schultz J, Lorenz P, Ibrahim SM, Kundt G, Gross G, Kunz M.

Mol Carcinog. 2009 Jan;48(1):14-23. doi: 10.1002/mc.20452.


Adenovirus vector-mediated Gli1 siRNA induces growth inhibition and apoptosis in human pancreatic cancer with Smo-dependent or Smo-independent Hh pathway activation in vitro and in vivo.

Guo J, Gao J, Li Z, Gong Y, Man X, Jin J, Wu H.

Cancer Lett. 2013 Oct 10;339(2):185-94. doi: 10.1016/j.canlet.2013.06.010. Epub 2013 Jun 18.


The prognostic significance and therapeutic potential of hedgehog signaling in intrahepatic cholangiocellular carcinoma.

Tang L, Tan YX, Jiang BG, Pan YF, Li SX, Yang GZ, Wang M, Wang Q, Zhang J, Zhou WP, Dong LW, Wang HY.

Clin Cancer Res. 2013 Apr 15;19(8):2014-24. doi: 10.1158/1078-0432.CCR-12-0349. Epub 2013 Mar 14.


Hedgehog-GLI signaling drives self-renewal and tumorigenicity of human melanoma-initiating cells.

Santini R, Vinci MC, Pandolfi S, Penachioni JY, Montagnani V, Olivito B, Gattai R, Pimpinelli N, Gerlini G, Borgognoni L, Stecca B.

Stem Cells. 2012 Sep;30(9):1808-18. doi: 10.1002/stem.1160.


The Hedgehog pathway is a possible therapeutic target for patients with estrogen receptor-negative breast cancer.

Kameda C, Tanaka H, Yamasaki A, Nakamura M, Koga K, Sato N, Kubo M, Kuroki S, Tanaka M, Katano M.

Anticancer Res. 2009 Mar;29(3):871-9.

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