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Items: 1 to 20 of 233

1.

A novel method, digital genome scanning detects KRAS gene amplification in gastric cancers: involvement of overexpressed wild-type KRAS in downstream signaling and cancer cell growth.

Mita H, Toyota M, Aoki F, Akashi H, Maruyama R, Sasaki Y, Suzuki H, Idogawa M, Kashima L, Yanagihara K, Fujita M, Hosokawa M, Kusano M, Sabau SV, Tatsumi H, Imai K, Shinomura Y, Tokino T.

BMC Cancer. 2009 Jun 23;9:198. doi: 10.1186/1471-2407-9-198.

2.

Whole genome gene copy number profiling of gastric cancer identifies PAK1 and KRAS gene amplification as therapy targets.

Qian Z, Zhu G, Tang L, Wang M, Zhang L, Fu J, Huang C, Fan S, Sun Y, Lv J, Dong H, Gao B, Su X, Yu D, Zang J, Zhang X, Ji J, Ji Q.

Genes Chromosomes Cancer. 2014 Nov;53(11):883-94. doi: 10.1002/gcc.22196. Epub 2014 Jun 17.

PMID:
24935174
3.

Genome-wide gene copy number and expression analysis of primary gastric tumors and gastric cancer cell lines.

Junnila S, Kokkola A, Karjalainen-Lindsberg ML, Puolakkainen P, Monni O.

BMC Cancer. 2010 Mar 1;10:73. doi: 10.1186/1471-2407-10-73.

4.

Amplification/overexpression of Aurora-A in human gastric carcinoma: potential role in differentiated type gastric carcinogenesis.

Kamada K, Yamada Y, Hirao T, Fujimoto H, Takahama Y, Ueno M, Takayama T, Naito A, Hirao S, Nakajima Y.

Oncol Rep. 2004 Sep;12(3):593-9.

PMID:
15289843
5.

Aplasia ras homolog member I is downregulated in gastric cancer and silencing its expression promotes cell growth in vitro.

Tang HL, Hu YQ, Qin XP, Jazag A, Yang H, Yang YX, Yang XN, Liu JJ, Chen JM, Guleng B, Ren JL.

J Gastroenterol Hepatol. 2012 Aug;27(8):1395-404. doi: 10.1111/j.1440-1746.2012.07146.x.

PMID:
22497484
6.

Amplification of fibroblast growth factor receptor-1 in breast cancer and the effects of brivanib alaninate.

Shiang CY, Qi Y, Wang B, Lazar V, Wang J, Fraser Symmans W, Hortobagyi GN, Andre F, Pusztai L.

Breast Cancer Res Treat. 2010 Oct;123(3):747-55. doi: 10.1007/s10549-009-0677-6. Epub 2009 Dec 19.

PMID:
20024612
7.

BRAF, KRAS and PIK3CA mutations in colorectal serrated polyps and cancer: primary or secondary genetic events in colorectal carcinogenesis?

Velho S, Moutinho C, Cirnes L, Albuquerque C, Hamelin R, Schmitt F, Carneiro F, Oliveira C, Seruca R.

BMC Cancer. 2008 Sep 9;8:255. doi: 10.1186/1471-2407-8-255.

8.

Gastric cancer cell line Hs746T harbors a splice site mutation of c-Met causing juxtamembrane domain deletion.

Asaoka Y, Tada M, Ikenoue T, Seto M, Imai M, Miyabayashi K, Yamamoto K, Yamamoto S, Kudo Y, Mohri D, Isomura Y, Ijichi H, Tateishi K, Kanai F, Ogawa S, Omata M, Koike K.

Biochem Biophys Res Commun. 2010 Apr 16;394(4):1042-6. doi: 10.1016/j.bbrc.2010.03.120. Epub 2010 Mar 21.

PMID:
20331976
9.

Impact of MET amplification on gastric cancer: possible roles as a novel prognostic marker and a potential therapeutic target.

Lee J, Seo JW, Jun HJ, Ki CS, Park SH, Park YS, Lim HY, Choi MG, Bae JM, Sohn TS, Noh JH, Kim S, Jang HL, Kim JY, Kim KM, Kang WK, Park JO.

Oncol Rep. 2011 Jun;25(6):1517-24. doi: 10.3892/or.2011.1219. Epub 2011 Mar 18.

PMID:
21424128
10.

Sequencing of 279 cancer genes in ampullary carcinoma reveals trends relating to histologic subtypes and frequent amplification and overexpression of ERBB2 (HER2).

Hechtman JF, Liu W, Sadowska J, Zhen L, Borsu L, Arcila ME, Won HH, Shah RH, Berger MF, Vakiani E, Shia J, Klimstra DS.

Mod Pathol. 2015 Aug;28(8):1123-9. doi: 10.1038/modpathol.2015.57. Epub 2015 May 15.

11.

beta-catenin (CTNNB1) gene amplification: a new mechanism of protein overexpression in cancer.

Suriano G, Vrcelj N, Senz J, Ferreira P, Masoudi H, Cox K, Nabais S, Lopes C, Machado JC, Seruca R, Carneiro F, Huntsman DG.

Genes Chromosomes Cancer. 2005 Mar;42(3):238-46.

PMID:
15609344
12.

Epidermal growth factor receptor structural alterations in gastric cancer.

Moutinho C, Mateus AR, Milanezi F, Carneiro F, Seruca R, Suriano G.

BMC Cancer. 2008 Jan 16;8:10. doi: 10.1186/1471-2407-8-10.

13.

Sorafenib inhibits non-small cell lung cancer cell growth by targeting B-RAF in KRAS wild-type cells and C-RAF in KRAS mutant cells.

Takezawa K, Okamoto I, Yonesaka K, Hatashita E, Yamada Y, Fukuoka M, Nakagawa K.

Cancer Res. 2009 Aug 15;69(16):6515-21. doi: 10.1158/0008-5472.CAN-09-1076. Epub 2009 Jul 28.

14.

KCNE2, a down-regulated gene identified by in silico analysis, suppressed proliferation of gastric cancer cells.

Yanglin P, Lina Z, Zhiguo L, Na L, Haifeng J, Guoyun Z, Jie L, Jun W, Tao L, Li S, Taidong Q, Jianhong W, Daiming F.

Cancer Lett. 2007 Feb 8;246(1-2):129-38. Epub 2006 May 4.

PMID:
16677757
15.

ERBB2 amplifications in esophageal adenocarcinoma.

Dahlberg PS, Jacobson BA, Dahal G, Fink JM, Kratzke RA, Maddaus MA, Ferrin LJ.

Ann Thorac Surg. 2004 Nov;78(5):1790-800.

PMID:
15511476
16.

Analysis of EGFR, HER2, and TOP2A gene status and chromosomal polysomy in gastric adenocarcinoma from Chinese patients.

Liang Z, Zeng X, Gao J, Wu S, Wang P, Shi X, Zhang J, Liu T.

BMC Cancer. 2008 Dec 6;8:363. doi: 10.1186/1471-2407-8-363.

17.

The hepatocyte nuclear factor 3 alpha gene, HNF3alpha (FOXA1), on chromosome band 14q13 is amplified and overexpressed in esophageal and lung adenocarcinomas.

Lin L, Miller CT, Contreras JI, Prescott MS, Dagenais SL, Wu R, Yee J, Orringer MB, Misek DE, Hanash SM, Glover TW, Beer DG.

Cancer Res. 2002 Sep 15;62(18):5273-9.

18.

Mutations in FGFR3 and PIK3CA, singly or combined with RAS and AKT1, are associated with AKT but not with MAPK pathway activation in urothelial bladder cancer.

Juanpere N, Agell L, Lorenzo M, de Muga S, López-Vilaró L, Murillo R, Mojal S, Serrano S, Lorente JA, Lloreta J, Hernández S.

Hum Pathol. 2012 Oct;43(10):1573-82. doi: 10.1016/j.humpath.2011.10.026. Epub 2012 Mar 12.

PMID:
22417847
19.

Alterations of p16INK4A and p15INK4B genes in gastric carcinomas.

Lee YY, Kang SH, Seo JY, Jung CW, Lee KU, Choe KJ, Kim BK, Kim NK, Koeffler HP, Bang YJ.

Cancer. 1997 Nov 15;80(10):1889-96.

PMID:
9366289
20.

NF-kappaB activates transcription of the RNA-binding factor HuR, via PI3K-AKT signaling, to promote gastric tumorigenesis.

Kang MJ, Ryu BK, Lee MG, Han J, Lee JH, Ha TK, Byun DS, Chae KS, Lee BH, Chun HS, Lee KY, Kim HJ, Chi SG.

Gastroenterology. 2008 Dec;135(6):2030-42, 2042.e1-3. doi: 10.1053/j.gastro.2008.08.009. Epub 2008 Aug 20.

PMID:
18824170

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