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Items: 1 to 20 of 356

1.

Ruthenium complexes endowed with potent anti-Trypanosoma cruzi activity: Synthesis, biological characterization and structure-activity relationships.

Donnici CL, Araújo MH, Oliveira HS, Moreira DR, Pereira VR, de Assis Souza M, de Castro MC, Leite AC.

Bioorg Med Chem. 2009 Jul 15;17(14):5038-43. doi: 10.1016/j.bmc.2009.05.071. Epub 2009 Jun 17.

PMID:
19539479
2.

Design, synthesis and cruzain docking of 3-(4-substituted-aryl)-1,2,4-oxadiazole-N-acylhydrazones as anti-Trypanosoma cruzi agents.

dos Santos Filho JM, Leite AC, de Oliveira BG, Moreira DR, Lima MS, Soares MB, Leite LF.

Bioorg Med Chem. 2009 Sep 15;17(18):6682-91. doi: 10.1016/j.bmc.2009.07.068. Epub 2009 Aug 6.

PMID:
19683450
3.

Synthesis and antitrypanosomal profile of new functionalized 1,3,4-thiadiazole-2-arylhydrazone derivatives, designed as non-mutagenic megazol analogues.

Carvalho SA, da Silva EF, Santa-Rita RM, de Castro SL, Fraga CA.

Bioorg Med Chem Lett. 2004 Dec 20;14(24):5967-70.

PMID:
15546709
4.

Synthesis, Cruzain docking, and in vitro studies of aryl-4-oxothiazolylhydrazones against Trypanosoma cruzi.

Leite AC, Moreira DR, Cardoso MV, Hernandes MZ, Alves Pereira VR, Silva RO, Kiperstok AC, Lima Mda S, Soares MB.

ChemMedChem. 2007 Sep;2(9):1339-45.

PMID:
17628867
5.

Studies toward the structural optimization of novel thiazolylhydrazone-based potent antitrypanosomal agents.

Hernandes MZ, Rabello MM, Leite AC, Cardoso MV, Moreira DR, Brondani DJ, Simone CA, Reis LC, Souza MA, Pereira VR, Ferreira RS, McKerrow JH.

Bioorg Med Chem. 2010 Nov 15;18(22):7826-35. doi: 10.1016/j.bmc.2010.09.056. Epub 2010 Sep 29.

PMID:
20961766
6.

Effect of ruthenium complexation on trypanocidal activity of 5-nitrofuryl containing thiosemicarbazones.

Pagano M, Demoro B, Toloza J, Boiani L, González M, Cerecetto H, Olea-Azar C, Norambuena E, Gambino D, Otero L.

Eur J Med Chem. 2009 Dec;44(12):4937-43. doi: 10.1016/j.ejmech.2009.08.008. Epub 2009 Aug 29.

PMID:
19783078
7.

Design and synthesis of new (E)-cinnamic N-acylhydrazones as potent antitrypanosomal agents.

Carvalho SA, Feitosa LO, Soares M, Costa TE, Henriques MG, Salomão K, de Castro SL, Kaiser M, Brun R, Wardell JL, Wardell SM, Trossini GH, Andricopulo AD, da Silva EF, Fraga CA.

Eur J Med Chem. 2012 Aug;54:512-21. doi: 10.1016/j.ejmech.2012.05.041. Epub 2012 Jun 7.

PMID:
22727447
8.

2-Pyridyl thiazoles as novel anti-Trypanosoma cruzi agents: structural design, synthesis and pharmacological evaluation.

Cardoso MV, de Siqueira LR, da Silva EB, Costa LB, Hernandes MZ, Rabello MM, Ferreira RS, da Cruz LF, Moreira DR, Pereira VR, de Castro MC, Bernhardt PV, Leite AC.

Eur J Med Chem. 2014 Oct 30;86:48-59. doi: 10.1016/j.ejmech.2014.08.012. Epub 2014 Aug 6.

PMID:
25147146
9.

Trypanocidal activity of 5,6-dihydropyran-2-ones against free trypomastigotes forms of Trypanosoma cruzi.

de Fátima A, Marquissolo C, de Albuquerque S, Carraro-Abrahão AA, Pilli RA.

Eur J Med Chem. 2006 Oct;41(10):1210-3. Epub 2006 Jul 3.

PMID:
16815596
10.

Antitrypanosomal activities and cytotoxicity of 5-nitro-2-furancarbohydrazides.

Millet R, Maes L, Landry V, Sergheraert C, Davioud-Charvet E.

Bioorg Med Chem Lett. 2002 Dec 16;12(24):3601-4.

PMID:
12443785
11.

Platinum-based complexes of bioactive 3-(5-nitrofuryl)acroleine thiosemicarbazones showing anti-Trypanosoma cruzi activity.

Vieites M, Otero L, Santos D, Olea-Azar C, Norambuena E, Aguirre G, Cerecetto H, González M, Kemmerling U, Morello A, Diego Maya J, Gambino D.

J Inorg Biochem. 2009 Mar;103(3):411-8. doi: 10.1016/j.jinorgbio.2008.12.004. Epub 2008 Dec 24.

PMID:
19187969
12.

Evaluation of some organic compounds on bloodstream forms of Trypanosoma cruzi.

Silva JS, Ferrioli-Filho F, Kanesiro MM, Ferreira VF, Santos SC, Pinto CN, Fonseca JL, Mizrahy HE, Gilbert B, Pinto MC, et al.

Mem Inst Oswaldo Cruz. 1992 Jul-Sep;87(3):345-51.

13.

Second generation of 5-ethenylbenzofuroxan derivatives as inhibitors of Trypanosoma cruzi growth: synthesis, biological evaluation, and structure-activity relationships.

Porcal W, Hernández P, Aguirre G, Boiani L, Boiani M, Merlino A, Ferreira A, Maio RD, Castro A, González M, Cerecetto H.

Bioorg Med Chem. 2007 Apr 1;15(7):2768-81. Epub 2007 Jan 12.

PMID:
17287123
14.

Phthalimido-thiazoles as building blocks and their effects on the growth and morphology of Trypanosoma cruzi.

Gomes PA, Oliveira AR, Cardoso MV, Santiago Ede F, Barbosa Mde O, de Siqueira LR, Moreira DR, Bastos TM, Brayner FA, Soares MB, Mendes AP, de Castro MC, Pereira VR, Leite AC.

Eur J Med Chem. 2016 Mar 23;111:46-57. doi: 10.1016/j.ejmech.2016.01.010. Epub 2016 Jan 11.

PMID:
26854377
15.

In vitro activity of N-benzenesulfonylbenzotriazole on Trypanosoma cruzi epimastigote and trypomastigote forms.

Becerra MC, Guiñazú N, Hergert LY, Pellegrini A, Mazzieri MR, Gea S, Albesa I.

Exp Parasitol. 2012 May;131(1):57-62. doi: 10.1016/j.exppara.2012.02.028. Epub 2012 Mar 8.

PMID:
22425748
17.

Structural design, synthesis and structure-activity relationships of thiazolidinones with enhanced anti-Trypanosoma cruzi activity.

Moreira DR, Leite AC, Cardoso MV, Srivastava RM, Hernandes MZ, Rabello MM, da Cruz LF, Ferreira RS, de Simone CA, Meira CS, Guimaraes ET, da Silva AC, dos Santos TA, Pereira VR, Soares MB.

ChemMedChem. 2014 Jan;9(1):177-88. doi: 10.1002/cmdc.201300354. Epub 2013 Nov 7.

PMID:
24203393
18.

Activity of "reversed" diamidines against Trypanosoma cruzi "in vitro".

Silva CF, Batista MM, Mota RA, de Souza EM, Stephens CE, Som P, Boykin DW, Soeiro Mde N.

Biochem Pharmacol. 2007 Jun 15;73(12):1939-46. Epub 2007 Mar 24.

PMID:
17462605
19.

New potent imidazoisoquinolinone derivatives as anti-Trypanosoma cruzi agents: biological evaluation and structure-activity relationships.

Bollini M, Casal JJ, Alvarez DE, Boiani L, González M, Cerecetto H, Bruno AM.

Bioorg Med Chem. 2009 Feb 15;17(4):1437-44. doi: 10.1016/j.bmc.2009.01.011. Epub 2009 Jan 15.

PMID:
19168363
20.

Nitrofurylsemicarbazone rhenium and ruthenium complexes as anti-trypanosomal agents.

Otero L, Aguirre G, Boiani L, Denicola A, Rigol C, Olea-Azar C, Maya JD, Morello A, González M, Gambino D, Cerecetto H.

Eur J Med Chem. 2006 Nov;41(11):1231-9. Epub 2006 Jul 7.

PMID:
16828524

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