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L-type calcium channel blockers exert an antiinflammatory effect by suppressing expression of plasminogen receptors on macrophages.

Das R, Burke T, Van Wagoner DR, Plow EF.

Circ Res. 2009 Jul 17;105(2):167-75. doi: 10.1161/CIRCRESAHA.109.200311. Epub 2009 Jun 11.


L-type calcium channel antagonists and suppression of expression of plasminogen receptors: is the missing link the L-type calcium channel?

Bkaily G, Jacques D.

Circ Res. 2009 Jul 17;105(2):112-3. doi: 10.1161/CIRCRESAHA.109.202028. No abstract available.


Histone H2B as a functionally important plasminogen receptor on macrophages.

Das R, Burke T, Plow EF.

Blood. 2007 Nov 15;110(10):3763-72. Epub 2007 Aug 9.


A new function for old drugs.

Das R, Plow EF.

Cell Cycle. 2010 Feb 15;9(4):638-9. Epub 2010 Feb 18. No abstract available.


Regulation of macrophage migration by a novel plasminogen receptor Plg-R KT.

Lighvani S, Baik N, Diggs JE, Khaldoyanidi S, Parmer RJ, Miles LA.

Blood. 2011 Nov 17;118(20):5622-30. doi: 10.1182/blood-2011-03-344242. Epub 2011 Sep 22.


Phosphatidylserine as an anchor for plasminogen and its plasminogen receptor, histone H2B, to the macrophage surface.

Das R, Plow EF.

J Thromb Haemost. 2011 Feb;9(2):339-49. doi: 10.1111/j.1538-7836.2010.04132.x.


Macrophage gene expression and foam cell formation are regulated by plasminogen.

Das R, Ganapathy S, Mahabeleshwar GH, Drumm C, Febbraio M, Jain MK, Plow EF.

Circulation. 2013 Mar 19;127(11):1209-18, e1-16. doi: 10.1161/CIRCULATIONAHA.112.001214. Epub 2013 Feb 11. Erratum in: Circulation. 2014 Feb 4;129(5):e326.


{beta}1-Adrenergic receptor activation induces mouse cardiac myocyte death through both L-type calcium channel-dependent and -independent pathways.

Wang W, Zhang H, Gao H, Kubo H, Berretta RM, Chen X, Houser SR.

Am J Physiol Heart Circ Physiol. 2010 Aug;299(2):H322-31. doi: 10.1152/ajpheart.00392.2010. Epub 2010 May 21.


New insights into the role of Plg-RKT in macrophage recruitment.

Miles LA, Lighvani S, Baik N, Parmer CM, Khaldoyanidi S, Mueller BM, Parmer RJ.

Int Rev Cell Mol Biol. 2014;309:259-302. doi: 10.1016/B978-0-12-800255-1.00005-3. Review.


Plasminogen promotes macrophage phagocytosis in mice.

Das R, Ganapathy S, Settle M, Plow EF.

Blood. 2014 Jul 31;124(5):679-88. doi: 10.1182/blood-2014-01-549659. Epub 2014 May 29.


State-dependent verapamil block of the cloned human Ca(v)3.1 T-type Ca(2+) channel.

Freeze BS, McNulty MM, Hanck DA.

Mol Pharmacol. 2006 Aug;70(2):718-26. Epub 2006 May 12.


L-type Ca2+ channels in mast cells: activation by membrane depolarization and distinct roles in regulating mediator release from store-operated Ca2+ channels.

Yoshimaru T, Suzuki Y, Inoue T, Ra C.

Mol Immunol. 2009 Apr;46(7):1267-77. doi: 10.1016/j.molimm.2008.11.011. Epub 2009 Jan 6.


Plasminogen deficiency differentially affects recruitment of inflammatory cell populations in mice.

Ploplis VA, French EL, Carmeliet P, Collen D, Plow EF.

Blood. 1998 Mar 15;91(6):2005-9.


Chronic verapamil treatment remodels ICa,L in mouse ventricle.

Schroder E, Magyar J, Burgess D, Andres D, Satin J.

Am J Physiol Heart Circ Physiol. 2007 Apr;292(4):H1906-16. Epub 2006 Dec 8.


Calcium channel blockers reduce blood pressure in part by inhibiting vascular smooth muscle carbonic anhydrase I.

Puscas L, Gilau L, Coltau M, Pasca R, Domuta G, Baican M, Hecht A.

Cardiovasc Drugs Ther. 2000 Oct;14(5):523-8.


Broad-spectrum antiemetic efficacy of the L-type calcium channel blocker amlodipine in the least shrew (Cryptotis parva).

Zhong W, Chebolu S, Darmani NA.

Pharmacol Biochem Behav. 2014 May;120:124-32. doi: 10.1016/j.pbb.2014.03.005. Epub 2014 Mar 12.


Plasmin and plasminogen induce macrophage reprogramming and regulate key steps of inflammation resolution via annexin A1.

Sugimoto MA, Ribeiro ALC, Costa BRC, Vago JP, Lima KM, Carneiro FS, Ortiz MMO, Lima GLN, Carmo AAF, Rocha RM, Perez DA, Reis AC, Pinho V, Miles LA, Garcia CC, Teixeira MM, Sousa LP.

Blood. 2017 May 25;129(21):2896-2907. doi: 10.1182/blood-2016-09-742825. Epub 2017 Mar 20. Erratum in: Blood. 2018 Jul 26;132(4):459.


Moonlighting glycolytic protein glyceraldehyde-3-phosphate dehydrogenase (GAPDH): an evolutionarily conserved plasminogen receptor on mammalian cells.

Chauhan AS, Kumar M, Chaudhary S, Patidar A, Dhiman A, Sheokand N, Malhotra H, Raje CI, Raje M.

FASEB J. 2017 Jun;31(6):2638-2648. doi: 10.1096/fj.201600982R. Epub 2017 Mar 15.


L-type calcium channel inhibitor diltiazem prevents aneurysm formation by blood pressure-independent anti-inflammatory effects.

Mieth A, Revermann M, Babelova A, Weigert A, Schermuly RT, Brandes RP.

Hypertension. 2013 Dec;62(6):1098-104. doi: 10.1161/HYPERTENSIONAHA.113.01986. Epub 2013 Sep 30.


Deficiency of plasminogen receptor, Plg-RKT , causes defects in plasminogen binding and inflammatory macrophage recruitment in vivo.

Miles LA, Baik N, Lighvani S, Khaldoyanidi S, Varki NM, Bai H, Mueller BM, Parmer RJ.

J Thromb Haemost. 2017 Jan;15(1):155-162. doi: 10.1111/jth.13532. Epub 2016 Nov 28.

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