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Dysregulation of the Wnt pathway inhibits timely myelination and remyelination in the mammalian CNS.

Fancy SP, Baranzini SE, Zhao C, Yuk DI, Irvine KA, Kaing S, Sanai N, Franklin RJ, Rowitch DH.

Genes Dev. 2009 Jul 1;23(13):1571-85. doi: 10.1101/gad.1806309. Epub 2009 Jun 10.


The Wnt effector transcription factor 7-like 2 positively regulates oligodendrocyte differentiation in a manner independent of Wnt/β-catenin signaling.

Hammond E, Lang J, Maeda Y, Pleasure D, Angus-Hill M, Xu J, Horiuchi M, Deng W, Guo F.

J Neurosci. 2015 Mar 25;35(12):5007-22. doi: 10.1523/JNEUROSCI.4787-14.2015.


Myelin transcription factor 1 (Myt1) expression in demyelinated lesions of rodent and human CNS.

Vana AC, Lucchinetti CF, Le TQ, Armstrong RC.

Glia. 2007 May;55(7):687-97.


Axin2 as regulatory and therapeutic target in newborn brain injury and remyelination.

Fancy SP, Harrington EP, Yuen TJ, Silbereis JC, Zhao C, Baranzini SE, Bruce CC, Otero JJ, Huang EJ, Nusse R, Franklin RJ, Rowitch DH.

Nat Neurosci. 2011 Jun 26;14(8):1009-16. doi: 10.1038/nn.2855.


Dual-mode modulation of Smad signaling by Smad-interacting protein Sip1 is required for myelination in the central nervous system.

Weng Q, Chen Y, Wang H, Xu X, Yang B, He Q, Shou W, Chen Y, Higashi Y, van den Berghe V, Seuntjens E, Kernie SG, Bukshpun P, Sherr EH, Huylebroeck D, Lu QR.

Neuron. 2012 Feb 23;73(4):713-28. doi: 10.1016/j.neuron.2011.12.021. Erratum in: Neuron. 2012 Oct 18;76(2):462.


Analysis of the Wnt/B-catenin/TCF4 pathway using SAGE, genome-wide microarray and promoter analysis: Identification of BRI3 and HSF2 as novel targets.

Kavak E, Najafov A, Ozturk N, Seker T, Cavusoglu K, Aslan T, Duru AD, Saygili T, Hoxhaj G, Hiz MC, Unal DO, Birgül-Iyison N, Ozturk M, Koman A.

Cell Signal. 2010 Oct;22(10):1523-35. doi: 10.1016/j.cellsig.2010.05.021. Epub 2010 Jun 9.


MENA is a transcriptional target of the Wnt/beta-catenin pathway.

Najafov A, Seker T, Even I, Hoxhaj G, Selvi O, Ozel DE, Koman A, Birgül-İyison N.

PLoS One. 2012;7(5):e37013. doi: 10.1371/journal.pone.0037013. Epub 2012 May 17.


The β-catenin/TCF complex as a novel target of resveratrol in the Wnt/β-catenin signaling pathway.

Chen HJ, Hsu LS, Shia YT, Lin MW, Lin CM.

Biochem Pharmacol. 2012 Nov 1;84(9):1143-53. doi: 10.1016/j.bcp.2012.08.011. Epub 2012 Aug 19.


The role of oligodendrocytes and oligodendrocyte progenitors in CNS remyelination.

Keirstead HS, Blakemore WF.

Adv Exp Med Biol. 1999;468:183-97. Review.


Wnt/beta-catenin signaling is an essential and direct driver of myelin gene expression and myelinogenesis.

Tawk M, Makoukji J, Belle M, Fonte C, Trousson A, Hawkins T, Li H, Ghandour S, Schumacher M, Massaad C.

J Neurosci. 2011 Mar 9;31(10):3729-42. doi: 10.1523/JNEUROSCI.4270-10.2011.


Phospholipase D1 drives a positive feedback loop to reinforce the Wnt/beta-catenin/TCF signaling axis.

Kang DW, Lee SH, Yoon JW, Park WS, Choi KY, Min do S.

Cancer Res. 2010 May 15;70(10):4233-42. doi: 10.1158/0008-5472.CAN-09-3470. Epub 2010 May 4.


Canonical Wnt signaling in the oligodendroglial lineage--puzzles remain.

Guo F, Lang J, Sohn J, Hammond E, Chang M, Pleasure D.

Glia. 2015 Oct;63(10):1671-93. doi: 10.1002/glia.22813. Epub 2015 Mar 18. Review.


Evidence that nuclear factor IA inhibits repair after white matter injury.

Fancy SP, Glasgow SM, Finley M, Rowitch DH, Deneen B.

Ann Neurol. 2012 Aug;72(2):224-33. doi: 10.1002/ana.23590. Epub 2012 Jul 17.


The Notch-2 gene is regulated by Wnt signaling in cultured colorectal cancer cells.

Ungerbäck J, Elander N, Grünberg J, Sigvardsson M, Söderkvist P.

PLoS One. 2011 Mar 18;6(3):e17957. doi: 10.1371/journal.pone.0017957.


Human telomerase reverse transcriptase (hTERT) is a novel target of the Wnt/β-catenin pathway in human cancer.

Zhang Y, Toh L, Lau P, Wang X.

J Biol Chem. 2012 Sep 21;287(39):32494-511. Epub 2012 Jul 31.


Wnt signaling in remyelination in multiple sclerosis: friend or foe?

Xie C, Li Z, Zhang GX, Guan Y.

Mol Neurobiol. 2014 Jun;49(3):1117-25. doi: 10.1007/s12035-013-8584-6. Epub 2013 Nov 16. Review.


A dynamic exchange of TCF3 and TCF4 transcription factors controls MYC expression in colorectal cancer cells.

Shah M, Rennoll SA, Raup-Konsavage WM, Yochum GS.

Cell Cycle. 2015;14(3):323-32. doi: 10.4161/15384101.2014.980643.


Beta-catenin-mediated Wnt signaling regulates neurogenesis in the ventral telencephalon.

Gulacsi AA, Anderson SA.

Nat Neurosci. 2008 Dec;11(12):1383-91. doi: 10.1038/nn.2226. Epub 2008 Nov 9.


Stage-specific regulation of oligodendrocyte development by Wnt/β-catenin signaling.

Dai ZM, Sun S, Wang C, Huang H, Hu X, Zhang Z, Lu QR, Qiu M.

J Neurosci. 2014 Jun 18;34(25):8467-73. doi: 10.1523/JNEUROSCI.0311-14.2014.


Limited TCF7L2 expression in MS lesions.

Lürbke A, Hagemeier K, Cui QL, Metz I, Brück W, Antel J, Kuhlmann T.

PLoS One. 2013 Aug 20;8(8):e72822. doi: 10.1371/journal.pone.0072822. eCollection 2013.

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