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Items: 1 to 20 of 115

1.

Making medicinal chemistry more effective--application of Lean Sigma to improve processes, speed and quality.

Andersson S, Armstrong A, Björe A, Bowker S, Chapman S, Davies R, Donald C, Egner B, Elebring T, Holmqvist S, Inghardt T, Johannesson P, Johansson M, Johnstone C, Kemmitt P, Kihlberg J, Korsgren P, Lemurell M, Moore J, Pettersson JA, Pointon H, Pontén F, Schofield P, Selmi N, Whittamore P.

Drug Discov Today. 2009 Jun;14(11-12):598-604. doi: 10.1016/j.drudis.2009.03.005. Epub 2009 Mar 11. Review.

PMID:
19508922
2.

Recent applications of microwave irradiation to medicinal chemistry.

Alcázar J, Oehlrich D.

Future Med Chem. 2010 Feb;2(2):169-76. doi: 10.4155/fmc.09.144. Review.

PMID:
21426184
3.

Six Sigma: not for the faint of heart.

Benedetto AR.

Radiol Manage. 2003 Mar-Apr;25(2):40-53.

PMID:
12800564
4.

Medicinal chemistry matters - a call for discipline in our discipline.

Johnstone C.

Drug Discov Today. 2012 Jun;17(11-12):538-43. doi: 10.1016/j.drudis.2012.01.010. Epub 2012 Jan 25.

PMID:
22301070
5.

Applications of process analytical technology to crystallization processes.

Yu LX, Lionberger RA, Raw AS, D'Costa R, Wu H, Hussain AS.

Adv Drug Deliv Rev. 2004 Feb 23;56(3):349-69. Review.

PMID:
14962586
6.

Transforming fragments into candidates: small becomes big in medicinal chemistry.

de Kloe GE, Bailey D, Leurs R, de Esch IJ.

Drug Discov Today. 2009 Jul;14(13-14):630-46. doi: 10.1016/j.drudis.2009.03.009. Epub 2009 Mar 31. Review.

PMID:
19443265
7.

Timely synthetic support for medicinal chemists.

Potoski J.

Drug Discov Today. 2005 Jan 15;10(2):115-20. Review.

PMID:
15718160
8.

Optimized delivery radiological reports: applying Six Sigma methodology to a radiology department.

Cavagna E, Berletti R, Schiavon F, Scarsi B, Barbato G.

Radiol Med. 2003 Mar;105(3):205-14. English, Italian.

PMID:
12835644
9.

Life in the fast lane: high-throughput chemistry for lead generation and optimisation.

Hunter D.

J Cell Biochem Suppl. 2001;Suppl 37:22-7. Review.

PMID:
11842424
10.

New opportunities for biocatalysis: making pharmaceutical processes greener.

Woodley JM.

Trends Biotechnol. 2008 Jun;26(6):321-7. doi: 10.1016/j.tibtech.2008.03.004. Epub 2008 Apr 22. Review.

PMID:
18436317
11.

Biocatalysis for pharmaceutical intermediates: the future is now.

Pollard DJ, Woodley JM.

Trends Biotechnol. 2007 Feb;25(2):66-73. Epub 2006 Dec 20. Review.

PMID:
17184862
12.

The impact of microwave synthesis on drug discovery.

Kappe CO, Dallinger D.

Nat Rev Drug Discov. 2006 Jan;5(1):51-63. Review.

PMID:
16374514
13.

Process Analytical Technology (PAT): batch-to-batch reproducibility of fermentation processes by robust process operational design and control.

Gnoth S, Jenzsch M, Simutis R, Lübbert A.

J Biotechnol. 2007 Oct 31;132(2):180-6. Epub 2007 Apr 29.

PMID:
17559961
14.

Handing over the baton: connecting medicinal chemistry with process R&D.

Federsel HJ.

Drug News Perspect. 2008 May;21(4):193-9. doi: 10.1358/dnp.2008.21.4.1213348.

PMID:
18560618
15.

The central role of chemistry in 'quality by design' approaches to drug development.

Grewal NK, Leadbeater NE.

Future Med Chem. 2012 Sep;4(14):1799-810. doi: 10.4155/fmc.12.117.

PMID:
23043477
16.

Recent trends in microwave-assisted synthesis.

Wilson NS, Roth GP.

Curr Opin Drug Discov Devel. 2002 Jul;5(4):620-9. Review.

PMID:
12197320
17.

Innovation leading the way: application of lean manufacturing to sample management.

Allen M, Wigglesworth MJ.

J Biomol Screen. 2009 Jun;14(5):515-22. doi: 10.1177/1087057109336587. Epub 2009 May 29.

PMID:
19483142
18.

Improving drug manufacturing with process analytical technology.

Rodrigues LO, Alves TP, Cardoso JP, Menezes JC.

IDrugs. 2006 Jan;9(1):44-8.

PMID:
16374733
19.
20.

Expediting drug discovery: recent advances in fast medicinal chemistry--optimization of hits and leads.

Edwards PJ, Allart B, Andrews MJ, Clase JA, Menet C.

Curr Opin Drug Discov Devel. 2006 Jul;9(4):425-44. Review.

PMID:
16889227

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