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Items: 1 to 20 of 148

1.

Sphingomyelin synthase-related protein SMSr controls ceramide homeostasis in the ER.

Vacaru AM, Tafesse FG, Ternes P, Kondylis V, Hermansson M, Brouwers JF, Somerharju P, Rabouille C, Holthuis JC.

J Cell Biol. 2009 Jun 15;185(6):1013-27. doi: 10.1083/jcb.200903152. Epub 2009 Jun 8.

2.

Sphingomyelin synthase-related protein SMSr is a suppressor of ceramide-induced mitochondrial apoptosis.

Tafesse FG, Vacaru AM, Bosma EF, Hermansson M, Jain A, Hilderink A, Somerharju P, Holthuis JC.

J Cell Sci. 2014 Jan 15;127(Pt 2):445-54. doi: 10.1242/jcs.138933. Epub 2013 Nov 20.

3.

Both sphingomyelin synthases SMS1 and SMS2 are required for sphingomyelin homeostasis and growth in human HeLa cells.

Tafesse FG, Huitema K, Hermansson M, van der Poel S, van den Dikkenberg J, Uphoff A, Somerharju P, Holthuis JC.

J Biol Chem. 2007 Jun 15;282(24):17537-47. Epub 2007 Apr 22.

4.

Sphingomyelin synthase SMS2 displays dual activity as ceramide phosphoethanolamine synthase.

Ternes P, Brouwers JF, van den Dikkenberg J, Holthuis JC.

J Lipid Res. 2009 Nov;50(11):2270-7. doi: 10.1194/jlr.M900230-JLR200. Epub 2009 May 19.

5.

All members in the sphingomyelin synthase gene family have ceramide phosphoethanolamine synthase activity.

Ding T, Kabir I, Li Y, Lou C, Yazdanyar A, Xu J, Dong J, Zhou H, Park T, Boutjdir M, Li Z, Jiang XC.

J Lipid Res. 2015 Mar;56(3):537-45. doi: 10.1194/jlr.M054627. Epub 2015 Jan 20.

6.

Caspase-mediated inhibition of sphingomyelin synthesis is involved in FasL-triggered cell death.

Lafont E, Milhas D, Carpentier S, Garcia V, Jin ZX, Umehara H, Okazaki T, Schulze-Osthoff K, Levade T, Benoist H, Ségui B.

Cell Death Differ. 2010 Apr;17(4):642-54. doi: 10.1038/cdd.2009.130. Epub 2009 Sep 25.

7.

Inhibition of sphingomyelin synthase (SMS) affects intracellular sphingomyelin accumulation and plasma membrane lipid organization.

Li Z, Hailemariam TK, Zhou H, Li Y, Duckworth DC, Peake DA, Zhang Y, Kuo MS, Cao G, Jiang XC.

Biochim Biophys Acta. 2007 Sep;1771(9):1186-94. Epub 2007 Jun 6.

8.

Functional characterization of enzymes catalyzing ceramide phosphoethanolamine biosynthesis in mice.

Bickert A, Ginkel C, Kol M, vom Dorp K, Jastrow H, Degen J, Jacobs RL, Vance DE, Winterhager E, Jiang XC, Dörmann P, Somerharju P, Holthuis JC, Willecke K.

J Lipid Res. 2015 Apr;56(4):821-35. doi: 10.1194/jlr.M055269. Epub 2015 Feb 9. Erratum in: J Lipid Res. 2017 Apr;58(4):820.

9.

Switching head group selectivity in mammalian sphingolipid biosynthesis by active-site engineering of sphingomyelin synthases.

Kol M, Panatala R, Nordmann M, Swart L, van Suijlekom L, Cabukusta B, Hilderink A, Grabietz T, Mina JG, Somerharju P, Korneev S, Tafesse FG, Holthuis JC.

J Lipid Res. 2016 Jul;57(7):1273-85. doi: 10.1194/jlr.M068692. Epub 2016 May 10. Retraction in: J Lipid Res. 2017 Apr;58(4):821.

10.

SMS overexpression and knockdown: impact on cellular sphingomyelin and diacylglycerol metabolism, and cell apoptosis.

Ding T, Li Z, Hailemariam T, Mukherjee S, Maxfield FR, Wu MP, Jiang XC.

J Lipid Res. 2008 Feb;49(2):376-85. Epub 2007 Nov 2.

11.

Suppression of sphingomyelin synthase 1 by small interference RNA is associated with enhanced ceramide production and apoptosis after photodamage.

Separovic D, Semaan L, Tarca AL, Awad Maitah MY, Hanada K, Bielawski J, Villani M, Luberto C.

Exp Cell Res. 2008 May 1;314(8):1860-8. doi: 10.1016/j.yexcr.2008.02.008. Epub 2008 Feb 29.

12.

A novel inhibitor of ceramide trafficking from the endoplasmic reticulum to the site of sphingomyelin synthesis.

Yasuda S, Kitagawa H, Ueno M, Ishitani H, Fukasawa M, Nishijima M, Kobayashi S, Hanada K.

J Biol Chem. 2001 Nov 23;276(47):43994-4002. Epub 2001 Sep 6. Erratum in: J Biol Chem. 2013 Aug 16;288(33):24162.

13.

Role of membrane sphingomyelin and ceramide in platform formation for Fas-mediated apoptosis.

Miyaji M, Jin ZX, Yamaoka S, Amakawa R, Fukuhara S, Sato SB, Kobayashi T, Domae N, Mimori T, Bloom ET, Okazaki T, Umehara H.

J Exp Med. 2005 Jul 18;202(2):249-59. Epub 2005 Jul 11.

14.

Carboxyl-terminal Tail-mediated Homodimerizations of Sphingomyelin Synthases Are Responsible for Efficient Export from the Endoplasmic Reticulum.

Hayashi Y, Nemoto-Sasaki Y, Matsumoto N, Tanikawa T, Oka S, Tanaka Y, Arai S, Wada I, Sugiura T, Yamashita A.

J Biol Chem. 2017 Jan 20;292(3):1122-1141. doi: 10.1074/jbc.M116.746602. Epub 2016 Dec 7.

PMID:
27927984
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17.

Identification of a family of animal sphingomyelin synthases.

Huitema K, van den Dikkenberg J, Brouwers JF, Holthuis JC.

EMBO J. 2004 Jan 14;23(1):33-44. Epub 2003 Dec 18.

18.

Regulation and traffic of ceramide 1-phosphate produced by ceramide kinase: comparative analysis to glucosylceramide and sphingomyelin.

Boath A, Graf C, Lidome E, Ullrich T, Nussbaumer P, Bornancin F.

J Biol Chem. 2008 Mar 28;283(13):8517-26. Epub 2007 Dec 16.

19.

Novel Interconnections in Lipid Metabolism Revealed by Overexpression of Sphingomyelin Synthase-1.

Deevska GM, Dotson PP 2nd, Karakashian AA, Isaac G, Wrona M, Kelly SB, Merrill AH Jr, Nikolova-Karakashian MN.

J Biol Chem. 2017 Mar 24;292(12):5110-5122. doi: 10.1074/jbc.M116.751602. Epub 2017 Jan 13.

PMID:
28087695
20.

Impaired TCR signaling through dysfunction of lipid rafts in sphingomyelin synthase 1 (SMS1)-knockdown T cells.

Jin ZX, Huang CR, Dong L, Goda S, Kawanami T, Sawaki T, Sakai T, Tong XP, Masaki Y, Fukushima T, Tanaka M, Mimori T, Tojo H, Bloom ET, Okazaki T, Umehara H.

Int Immunol. 2008 Nov;20(11):1427-37. doi: 10.1093/intimm/dxn100. Epub 2008 Sep 26.

PMID:
18820264

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