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Items: 1 to 20 of 220

1.

Flaviviral methyltransferase/RNA interaction: structural basis for enzyme inhibition.

Milani M, Mastrangelo E, Bollati M, Selisko B, Decroly E, Bouvet M, Canard B, Bolognesi M.

Antiviral Res. 2009 Jul;83(1):28-34. doi: 10.1016/j.antiviral.2009.03.001. Epub 2009 Mar 14.

PMID:
19501254
2.

Recognition of RNA cap in the Wesselsbron virus NS5 methyltransferase domain: implications for RNA-capping mechanisms in Flavivirus.

Bollati M, Milani M, Mastrangelo E, Ricagno S, Tedeschi G, Nonnis S, Decroly E, Selisko B, de Lamballerie X, Coutard B, Canard B, Bolognesi M.

J Mol Biol. 2009 Jan 9;385(1):140-52. doi: 10.1016/j.jmb.2008.10.028. Epub 2008 Oct 19.

PMID:
18976670
3.

Biochemical characterization of the (nucleoside-2'O)-methyltransferase activity of dengue virus protein NS5 using purified capped RNA oligonucleotides (7Me)GpppAC(n) and GpppAC(n).

Selisko B, Peyrane FF, Canard B, Alvarez K, Decroly E.

J Gen Virol. 2010 Jan;91(Pt 1):112-21. doi: 10.1099/vir.0.015511-0. Epub 2009 Sep 23.

PMID:
19776234
4.

Structural and functional analysis of methylation and 5'-RNA sequence requirements of short capped RNAs by the methyltransferase domain of dengue virus NS5.

Egloff MP, Decroly E, Malet H, Selisko B, Benarroch D, Ferron F, Canard B.

J Mol Biol. 2007 Sep 21;372(3):723-36. Epub 2007 Jul 12.

PMID:
17686489
5.

Coronavirus nonstructural protein 16 is a cap-0 binding enzyme possessing (nucleoside-2'O)-methyltransferase activity.

Decroly E, Imbert I, Coutard B, Bouvet M, Selisko B, Alvarez K, Gorbalenya AE, Snijder EJ, Canard B.

J Virol. 2008 Aug;82(16):8071-84. doi: 10.1128/JVI.00407-08. Epub 2008 Apr 16.

6.

Mutagenesis of the dengue virus type 2 NS5 methyltransferase domain.

Kroschewski H, Lim SP, Butcher RE, Yap TL, Lescar J, Wright PJ, Vasudevan SG, Davidson AD.

J Biol Chem. 2008 Jul 11;283(28):19410-21. doi: 10.1074/jbc.M800613200. Epub 2008 May 9.

7.

Development of specific dengue virus 2'-O- and N7-methyltransferase assays for antiviral drug screening.

Barral K, Sallamand C, Petzold C, Coutard B, Collet A, Thillier Y, Zimmermann J, Vasseur JJ, Canard B, Rohayem J, Debart F, Decroly E.

Antiviral Res. 2013 Sep;99(3):292-300. doi: 10.1016/j.antiviral.2013.06.001. Epub 2013 Jun 12.

PMID:
23769894
8.

Structure of the methyltransferase domain from the Modoc virus, a flavivirus with no known vector.

Jansson AM, Jakobsson E, Johansson P, Lantez V, Coutard B, de Lamballerie X, Unge T, Jones TA.

Acta Crystallogr D Biol Crystallogr. 2009 Aug;65(Pt 8):796-803. doi: 10.1107/S0907444909017260. Epub 2009 Jul 10.

PMID:
19622863
9.

Structure and function of flavivirus NS5 methyltransferase.

Zhou Y, Ray D, Zhao Y, Dong H, Ren S, Li Z, Guo Y, Bernard KA, Shi PY, Li H.

J Virol. 2007 Apr;81(8):3891-903. Epub 2007 Jan 31.

10.

Structural bases for substrate recognition and activity in Meaban virus nucleoside-2'-O-methyltransferase.

Mastrangelo E, Bollati M, Milani M, Selisko B, Peyrane F, Canard B, Grard G, de Lamballerie X, Bolognesi M.

Protein Sci. 2007 Jun;16(6):1133-45. Epub 2007 May 1.

11.

Molecular basis for specific viral RNA recognition and 2'-O-ribose methylation by the dengue virus nonstructural protein 5 (NS5).

Zhao Y, Soh TS, Lim SP, Chung KY, Swaminathan K, Vasudevan SG, Shi PY, Lescar J, Luo D.

Proc Natl Acad Sci U S A. 2015 Dec 1;112(48):14834-9. doi: 10.1073/pnas.1514978112. Epub 2015 Nov 17.

12.

Crystal structure of the RNA polymerase domain of the West Nile virus non-structural protein 5.

Malet H, Egloff MP, Selisko B, Butcher RE, Wright PJ, Roberts M, Gruez A, Sulzenbacher G, Vonrhein C, Bricogne G, Mackenzie JM, Khromykh AA, Davidson AD, Canard B.

J Biol Chem. 2007 Apr 6;282(14):10678-89. Epub 2007 Feb 7.

13.

A structural basis for the inhibition of the NS5 dengue virus mRNA 2'-O-methyltransferase domain by ribavirin 5'-triphosphate.

Benarroch D, Egloff MP, Mulard L, Guerreiro C, Romette JL, Canard B.

J Biol Chem. 2004 Aug 20;279(34):35638-43. Epub 2004 May 19.

14.

Zika Virus Methyltransferase: Structure and Functions for Drug Design Perspectives.

Coutard B, Barral K, Lichière J, Selisko B, Martin B, Aouadi W, Lombardia MO, Debart F, Vasseur JJ, Guillemot JC, Canard B, Decroly E.

J Virol. 2017 Feb 14;91(5). pii: e02202-16. doi: 10.1128/JVI.02202-16. Print 2017 Mar 1.

15.

Virtual screening and bioassay study of novel inhibitors for dengue virus mRNA cap (nucleoside-2'O)-methyltransferase.

Luzhkov VB, Selisko B, Nordqvist A, Peyrane F, Decroly E, Alvarez K, Karlen A, Canard B, Qvist J.

Bioorg Med Chem. 2007 Dec 15;15(24):7795-802. Epub 2007 Aug 29. Erratum in: Bioorg Med Chem. 2008 Mar 15;16(6):3462.

PMID:
17888664
16.

Structure-function analysis of severe acute respiratory syndrome coronavirus RNA cap guanine-N7-methyltransferase.

Chen Y, Tao J, Sun Y, Wu A, Su C, Gao G, Cai H, Qiu S, Wu Y, Ahola T, Guo D.

J Virol. 2013 Jun;87(11):6296-305. doi: 10.1128/JVI.00061-13. Epub 2013 Mar 27.

17.

In vitro reconstitution of SARS-coronavirus mRNA cap methylation.

Bouvet M, Debarnot C, Imbert I, Selisko B, Snijder EJ, Canard B, Decroly E.

PLoS Pathog. 2010 Apr 22;6(4):e1000863. doi: 10.1371/journal.ppat.1000863. Erratum in: PLoS Pathog. 2010;6(5). doi: 10.1371/annotation/a0dde376-2eb1-4ce3-8887-d29f5ba6f162.

18.

The dengue virus NS5 protein as a target for drug discovery.

Lim SP, Noble CG, Shi PY.

Antiviral Res. 2015 Jul;119:57-67. doi: 10.1016/j.antiviral.2015.04.010. Epub 2015 Apr 24. Review.

PMID:
25912817
19.

Novel Broad Spectrum Inhibitors Targeting the Flavivirus Methyltransferase.

Brecher M, Chen H, Liu B, Banavali NK, Jones SA, Zhang J, Li Z, Kramer LD, Li H.

PLoS One. 2015 Jun 22;10(6):e0130062. doi: 10.1371/journal.pone.0130062. eCollection 2015.

20.

Binding of the Methyl Donor S-Adenosyl-l-Methionine to Middle East Respiratory Syndrome Coronavirus 2'-O-Methyltransferase nsp16 Promotes Recruitment of the Allosteric Activator nsp10.

Aouadi W, Blanjoie A, Vasseur JJ, Debart F, Canard B, Decroly E.

J Virol. 2017 Feb 14;91(5). pii: e02217-16. doi: 10.1128/JVI.02217-16. Print 2017 Mar 1.

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