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19497056,19788511,20975289,19767078,19264579,19281571,18320917,17761272,21300570,22909164,21884533,36326435,21756262,22193715,18445189,20664282,20541309,24635050,26091744,22197071,22856636,18535392,21195947,22691903,17653743,12861105,21601496,23173714,19492656,20818886,20123405,20377110,22801442,23025435,25669442,20441418,26911866,22192966,16750855,20946572,23653967,22584192,19167590,26826769,23484892,29166502,24274230,32435020,16630950,24850548,33168485,23987198,20471627,25872948,22314124,23866957,16334540,26171584,21258014,19635282,25609333,19359129,18167270,22841766,22065270,23312695,24983294,19949324,376558,15806011,21942916,25803207,28577900,28251901,23843378,26016741,24266596,19477491,19160940,30280305,24169059,15495244,20143645,22386830,22856635,22729959,20674826,19940422,29631595,27207174,20477582,16533452,20920772,30312677,32163480,2108593,22410711,27788880,2100542,33588897,23710659,29569504,20929607,28202404,22058099,17487816,14974880,22285754,22014012,28874235,26429506,25475444,21400938,17137866,24064203,27286778,33602658,30682573,29391286,22197274,23026185,20602665,24918666,25277223,29998524,15499486,17506955,9551333,2772500,28903805,8172581,17977544,12767961,30021471,32198128,20531165,26802388,22522852,19176173,26727765,17919148,1564970,11194524,28284781,31655295,25609328,27905115,9452682,21301265,30061443,30772477,32287168,24565773,17597280,23182795,20568386,28093999,24735226,18486799,21636327,21284353,29909591,26512744,25154179,6155097,21262094,18387221,21111483,23535096,11933207,23647478,27931305,21550133,20418292,18839625,23362781,28780879,9658691,20635155,19899257,25790805,23054691,22417938,17458439,22185739,12706530,25295804,17724112,11718165,10093876,25924832,21315535,1518394,20728035,28687110,11105624,9647267,27101900,24661784,24983261,30056152,19945350,30107868,29316335,21895469,23318225,21346404,18063242,35524357,14572815,30866985,36324138,724439,16835976,23634741,28662509,20377108,11508436,27364943,18824924,20955212,2926086,23121116,18655790,28258590,29954477,18727481,14572813,8829070,15857357,24468257,21426252,31234699,20538389,30837234,23844783,16271103,30314518,28441992,34879971,18070231,20053597,22149337,31796151,30539362,22543566,37114700,21229509,26756974,3323703,19093699,11231704,18839624,32445670,33646565,29607870,21923668,22800873,15125214,27871580,27699634,26250409,22946752,8964952,15875532,17620062,29958877,19942448,17976427,31268048,19014872,7668774,9553599,17559913,27017563,12426513,14696809,18035961,8560420,26978558,32066472,19894781,29629730,22123383,21457880,3617844,15168463,25660269,25609336,30968444,4081477,7978537,27940765,26419114,33122123,11199871,22219624,24797354,23890533,22001489,25758562,16313255,24432781,24556385,25369003,12144636,23033229,11143287,36408587,17966299,23878046,33581742,16451161,18220147,19752569,22289735,26850568,33485376,31826031,17223985,29688579,24921190,20052501,25249065,22830287,24928306,23582057,27247973,22195758,25219111,23254741,20667124,22299312,25551795,18374684,35868842,22282695,31721602,18205707,7872288,35016112,24573112,31395105,33197705,20889195,24202369,26304015,21333773,12058892,21039598,28825570,24384882,21262093,22568407,30132644,33640192,20865643,20362736,24522092,26111105,16490473,18467921,17594877,11315937,22683724,29485978,9225574,19843404,30462774,20627701,6693805,31203645,33109324,17357566,32251736,22909569,21262096,16529817,17692764,27582827,11270087,20024535,18220148,26540175,30386386,22928662,8301199,18337530,36528292,17039649,2529797,26821285,23548529,23517035,23063583,29439936,20859877,17768103,18158172,27687418,19656474,10699156,25520740,14600687,18204284,22129507,28412283,26011518,34346157,21800671,36301749,22686628,29249111,21950301,27660422,16728895,33791951,23915279,433971,20804470,25584911,33220126,22882421,27329469,23490322,28178173,14635117,15049404,29709957,35393279,24667369,26972189,16464219,22748405,26496459,28687109,2298129,11432329,20359432,26118352,15193471,25454013,16210064,25527240,25689810,21208116,33109322,22765833,24054366,20628406,25308409,22884590,21130380,9816408,15580551,23678665,26161706,19798727,15596404,24490128,20866113,19558006,33980333,23968383,22142940,24176215,8765863,29694969,27686124,20818894,25583256,23689241,25178775,23548526,31695331,21802816,23689240,34991189,29666724,33685557,22784006,23484891,22359877,33109318,26969268,27788882,21481442,23952985,33026762,16865874,23014586,7846659,16076313,19709101,21595592,25704296,32538357,10355153,20724964,17085283,28381322,28328347,8775319,28986975,30504393,20806108,36744397,2013670,16638441,20649895,24176214,17085281,26654922,19706314,31657963,33012673,17229465,24215253,24125136,14572818,33349293,31347612,20695852,22626603,17085285,17427507,31653632,23507325,19162547,21991862,21457889,14572814,14714307,36869013,22456213,35093554,22276768,25499251,10870115,9169034,10651345,33769522,24617010,12956349,18997129,16610507,32962702,18329867,24656708,20818887,34904566,25098147,7464402,24827773,17270096,25707325,2749621,30717879,19114897,6993183,17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Results by year

Year	Number of Results
1978	1
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1989	4
1990	3
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1992	3
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1994	2
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2020	29
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2024	1

784 results

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Page 1

C1-inhibitor concentrate for individual replacement therapy in patients with severe hereditary angioedema refractory to danazol prophylaxis.

Kreuz W, Martinez-Saguer I, Aygören-Pürsün E, Rusicke E, Heller C, Klingebiel T. Kreuz W, et al. Transfusion. 2009 Sep;49(9):1987-95. doi: 10.1111/j.1537-2995.2009.02230.x. Epub 2009 May 20. Transfusion. 2009. PMID: 19497056 Clinical Trial.

Pharmacokinetic analysis of human plasma-derived pasteurized C1-inhibitor concentrate in adults and children with hereditary angioedema: a prospective study.

Martinez-Saguer I, Rusicke E, Aygören-Pürsün E, von Hentig N, Klingebiel T, Kreuz W. Martinez-Saguer I, et al. Transfusion. 2010 Feb;50(2):354-60. doi: 10.1111/j.1537-2995.2009.02394.x. Epub 2009 Sep 24. Transfusion. 2010. PMID: 19788511

Long-term prophylaxis of hereditary angioedema with a pasteurized C1 inhibitor concentrate.

Tallroth GA. Tallroth GA. Int Arch Allergy Immunol. 2011;154(4):356-9. doi: 10.1159/000321830. Epub 2010 Oct 26. Int Arch Allergy Immunol. 2011. PMID: 20975289

Efficacy of human C1 esterase inhibitor concentrate compared with placebo in acute hereditary angioedema attacks.

Craig TJ, Levy RJ, Wasserman RL, Bewtra AK, Hurewitz D, Obtułowicz K, Reshef A, Ritchie B, Moldovan D, Shirov T, Grivcheva-Panovska V, Kiessling PC, Keinecke HO, Bernstein JA. Craig TJ, et al. J Allergy Clin Immunol. 2009 Oct;124(4):801-8. doi: 10.1016/j.jaci.2009.07.017. Epub 2009 Sep 19. J Allergy Clin Immunol. 2009. PMID: 19767078 Clinical Trial.

Self-administration of intravenous C1-inhibitor therapy for hereditary angioedema and associated quality of life benefits.

Bygum A, Andersen KE, Mikkelsen CS. Bygum A, et al. Eur J Dermatol. 2009 Mar-Apr;19(2):147-51. doi: 10.1684/ejd.2008.0603. Eur J Dermatol. 2009. PMID: 19264579

Hereditary angioedema and pregnancy.

Chinniah N, Katelaris CH. Chinniah N, et al. Aust N Z J Obstet Gynaecol. 2009 Feb;49(1):2-5. doi: 10.1111/j.1479-828X.2008.00945.x. Aust N Z J Obstet Gynaecol. 2009. PMID: 19281571

Benefits and risks of danazol in hereditary angioedema: a long-term survey of 118 patients.

Bork K, Bygum A, Hardt J. Bork K, et al. Ann Allergy Asthma Immunol. 2008 Feb;100(2):153-61. doi: 10.1016/S1081-1206(10)60424-3. Ann Allergy Asthma Immunol. 2008. PMID: 18320917

Hereditary angioedema: a decade of human C1-inhibitor concentrate therapy.

Farkas H, Jakab L, Temesszentandrási G, Visy B, Harmat G, Füst G, Széplaki G, Fekete B, Karádi I, Varga L. Farkas H, et al. J Allergy Clin Immunol. 2007 Oct;120(4):941-7. doi: 10.1016/j.jaci.2007.06.026. Epub 2007 Aug 29. J Allergy Clin Immunol. 2007. PMID: 17761272

Parameters of the classical complement pathway predict disease severity in hereditary angioedema.

Csuka D, Füst G, Farkas H, Varga L. Csuka D, et al. Clin Immunol. 2011 Apr;139(1):85-93. doi: 10.1016/j.clim.2011.01.003. Epub 2011 Jan 20. Clin Immunol. 2011. PMID: 21300570

Efficacy and safety of recombinant human C1-inhibitor for the treatment of attacks of hereditary angioedema: European open-label extension study.

Moldovan D, Reshef A, Fabiani J, Kivity S, Toubi E, Shlesinger M, Triggiani M, Montinaro V, Cillari E, Realdi G, Cancian M, Visscher S, Zanichelli A, Relan A, Cicardi M. Moldovan D, et al. Clin Exp Allergy. 2012 Jun;42(6):929-35. doi: 10.1111/j.1365-2222.2012.03984.x. Clin Exp Allergy. 2012. PMID: 22909164 Clinical Trial.

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