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Items: 14

1.
2.

Begacestat (GSI-953): a novel, selective thiophene sulfonamide inhibitor of amyloid precursor protein gamma-secretase for the treatment of Alzheimer's disease.

Martone RL, Zhou H, Atchison K, Comery T, Xu JZ, Huang X, Gong X, Jin M, Kreft A, Harrison B, Mayer SC, Aschmies S, Gonzales C, Zaleska MM, Riddell DR, Wagner E, Lu P, Sun SC, Sonnenberg-Reines J, Oganesian A, Adkins K, Leach MW, Clarke DW, Huryn D, Abou-Gharbia M, Magolda R, Bard J, Frick G, Raje S, Forlow SB, Balliet C, Burczynski ME, Reinhart PH, Wan HI, Pangalos MN, Jacobsen JS.

J Pharmacol Exp Ther. 2009 Nov;331(2):598-608. doi: 10.1124/jpet.109.152975. Epub 2009 Aug 11.

3.

Oxidative stress damage and oxidative stress responses in the choroid plexus in Alzheimer's disease.

Perez-Gracia E, Blanco R, Carmona M, Carro E, Ferrer I.

Acta Neuropathol. 2009 Oct;118(4):497-504. doi: 10.1007/s00401-009-0574-4. Epub 2009 Jul 14.

PMID:
19597827
4.

Gangliosides determine the amyloid pathology of Alzheimer's disease.

Oikawa N, Yamaguchi H, Ogino K, Taki T, Yuyama K, Yamamoto N, Shin RW, Furukawa K, Yanagisawa K.

Neuroreport. 2009 Aug 5;20(12):1043-6. doi: 10.1097/WNR.0b013e32832e4b9d.

PMID:
19590389
5.

Differential damage in the frontal cortex with aging, sporadic and familial Alzheimer's disease.

Leuba G, Vernay A, Zimmermann V, Saini K, Kraftsik R, Savioz A.

Brain Res Bull. 2009 Oct 28;80(4-5):196-202. doi: 10.1016/j.brainresbull.2009.06.009. Epub 2009 Jun 25.

PMID:
19559767
6.

[Does acidosis in brain play a role in Alzheimer's disease?].

Pirchl M, Humpel C.

Neuropsychiatr. 2009;23(3):187-92. German.

PMID:
19703385
7.

Lithium trial in Alzheimer's disease: a randomized, single-blind, placebo-controlled, multicenter 10-week study.

Hampel H, Ewers M, Bürger K, Annas P, Mörtberg A, Bogstedt A, Frölich L, Schröder J, Schönknecht P, Riepe MW, Kraft I, Gasser T, Leyhe T, Möller HJ, Kurz A, Basun H.

J Clin Psychiatry. 2009 Jun;70(6):922-31.

PMID:
19573486
8.

Oxygen treatment triggers cognitive impairment in Alzheimer's transgenic mice.

Arendash GW, Cox AA, Mori T, Cracchiolo JR, Hensley KL, Roberts LJ 2nd.

Neuroreport. 2009 Aug 5;20(12):1087-92. doi: 10.1097/WNR.0b013e32832e6459.

PMID:
19543132
9.

Overexpression of Tfam protects mitochondria against beta-amyloid-induced oxidative damage in SH-SY5Y cells.

Xu S, Zhong M, Zhang L, Wang Y, Zhou Z, Hao Y, Zhang W, Yang X, Wei A, Pei L, Yu Z.

FEBS J. 2009 Jul;276(14):3800-9. doi: 10.1111/j.1742-4658.2009.07094.x. Epub 2009 Jun 3.

10.

Metallothionein-III knockout mice aggravates the neuronal damage after transient focal cerebral ischemia.

Koumura A, Hamanaka J, Shimazawa M, Honda A, Tsuruma K, Uchida Y, Hozumi I, Satoh M, Inuzuka T, Hara H.

Brain Res. 2009 Oct 6;1292:148-54. doi: 10.1016/j.brainres.2009.07.050. Epub 2009 Jul 25.

PMID:
19635467
11.

Fatal intracerebral haemorrhage following carotid endarterectomy in a patient with cerebral amyloid angiopathy.

Willems S, Debing E, Michotte A, Chaskis C, Van den Brande P.

Acta Chir Belg. 2009 Mar-Apr;109(2):245-7.

PMID:
19499692
12.

A PPARdelta agonist reduces amyloid burden and brain inflammation in a transgenic mouse model of Alzheimer's disease.

Kalinin S, Richardson JC, Feinstein DL.

Curr Alzheimer Res. 2009 Oct;6(5):431-7.

PMID:
19874267
13.

Antioxidant effects of epicatechin on the hippocampal toxicity caused by amyloid-beta 25-35 in rats.

Cuevas E, Limón D, Pérez-Severiano F, Díaz A, Ortega L, Zenteno E, Guevara J.

Eur J Pharmacol. 2009 Aug 15;616(1-3):122-7. doi: 10.1016/j.ejphar.2009.06.013. Epub 2009 Jun 17.

PMID:
19540227
14.

Cytoskeletal modulators and pleiotropic strategies for Alzheimer drug discovery.

Schenk D, Carrillo MC, Trojanowski JQ.

Alzheimers Dement. 2006 Oct;2(4):275-81. doi: 10.1016/j.jalz.2006.08.005.

PMID:
19595899

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