Sort by
Items per page

Send to

Choose Destination

Links from PubMed

Items: 1 to 20 of 243


Synthetic triterpenoids attenuate cytotoxic retinal injury: cross-talk between Nrf2 and PI3K/AKT signaling through inhibition of the lipid phosphatase PTEN.

Pitha-Rowe I, Liby K, Royce D, Sporn M.

Invest Ophthalmol Vis Sci. 2009 Nov;50(11):5339-47. doi: 10.1167/iovs.09-3648. Epub 2009 Jun 3.


Neuroprotective effect of Nrf2/ARE activators, CDDO ethylamide and CDDO trifluoroethylamide, in a mouse model of amyotrophic lateral sclerosis.

Neymotin A, Calingasan NY, Wille E, Naseri N, Petri S, Damiano M, Liby KT, Risingsong R, Sporn M, Beal MF, Kiaei M.

Free Radic Biol Med. 2011 Jul 1;51(1):88-96. doi: 10.1016/j.freeradbiomed.2011.03.027. Epub 2011 Mar 30.


Critical role of Nrf2 in oxidative stress-induced retinal ganglion cell death.

Himori N, Yamamoto K, Maruyama K, Ryu M, Taguchi K, Yamamoto M, Nakazawa T.

J Neurochem. 2013 Dec;127(5):669-80. doi: 10.1111/jnc.12325. Epub 2013 Jun 17.


Neuroprotective role of Nrf2 for retinal ganglion cells in ischemia-reperfusion.

Xu Z, Cho H, Hartsock MJ, Mitchell KL, Gong J, Wu L, Wei Y, Wang S, Thimmulappa RK, Sporn MB, Biswal S, Welsbie DS, Duh EJ.

J Neurochem. 2015 Apr;133(2):233-41. doi: 10.1111/jnc.13064. Epub 2015 Mar 4.


The synthetic triterpenoids, CDDO and CDDO-imidazolide, are potent inducers of heme oxygenase-1 and Nrf2/ARE signaling.

Liby K, Hock T, Yore MM, Suh N, Place AE, Risingsong R, Williams CR, Royce DB, Honda T, Honda Y, Gribble GW, Hill-Kapturczak N, Agarwal A, Sporn MB.

Cancer Res. 2005 Jun 1;65(11):4789-98.


CDDO-Im protects from acetaminophen hepatotoxicity through induction of Nrf2-dependent genes.

Reisman SA, Buckley DB, Tanaka Y, Klaassen CD.

Toxicol Appl Pharmacol. 2009 Apr 1;236(1):109-14. doi: 10.1016/j.taap.2008.12.024. Epub 2009 Jan 20.


Potent protection against aflatoxin-induced tumorigenesis through induction of Nrf2-regulated pathways by the triterpenoid 1-[2-cyano-3-,12-dioxooleana-1,9(11)-dien-28-oyl]imidazole.

Yates MS, Kwak MK, Egner PA, Groopman JD, Bodreddigari S, Sutter TR, Baumgartner KJ, Roebuck BD, Liby KT, Yore MM, Honda T, Gribble GW, Sporn MB, Kensler TW.

Cancer Res. 2006 Feb 15;66(4):2488-94.


Pharmacodynamic characterization of chemopreventive triterpenoids as exceptionally potent inducers of Nrf2-regulated genes.

Yates MS, Tauchi M, Katsuoka F, Flanders KC, Liby KT, Honda T, Gribble GW, Johnson DA, Johnson JA, Burton NC, Guilarte TR, Yamamoto M, Sporn MB, Kensler TW.

Mol Cancer Ther. 2007 Jan;6(1):154-62.


Preclinical evaluation of targeting the Nrf2 pathway by triterpenoids (CDDO-Im and CDDO-Me) for protection from LPS-induced inflammatory response and reactive oxygen species in human peripheral blood mononuclear cells and neutrophils.

Thimmulappa RK, Fuchs RJ, Malhotra D, Scollick C, Traore K, Bream JH, Trush MA, Liby KT, Sporn MB, Kensler TW, Biswal S.

Antioxid Redox Signal. 2007 Nov;9(11):1963-70.


Cytoprotection of human endothelial cells against oxidative stress by 1-[2-cyano-3,12-dioxooleana-1,9(11)-dien-28-oyl]imidazole (CDDO-Im): application of systems biology to understand the mechanism of action.

Wang X, Bynum JA, Stavchansky S, Bowman PD.

Eur J Pharmacol. 2014 Jul 5;734:122-31. doi: 10.1016/j.ejphar.2014.03.033. Epub 2014 Apr 3.


Cytoprotective effect of thioredoxin against retinal photic injury in mice.

Tanito M, Masutani H, Nakamura H, Ohira A, Yodoi J.

Invest Ophthalmol Vis Sci. 2002 Apr;43(4):1162-7.


Genetic or pharmacologic amplification of nrf2 signaling inhibits acute inflammatory liver injury in mice.

Osburn WO, Yates MS, Dolan PD, Chen S, Liby KT, Sporn MB, Taguchi K, Yamamoto M, Kensler TW.

Toxicol Sci. 2008 Jul;104(1):218-27. doi: 10.1093/toxsci/kfn079. Epub 2008 Apr 15.


Escin activates AKT-Nrf2 signaling to protect retinal pigment epithelium cells from oxidative stress.

Wang K, Jiang Y, Wang W, Ma J, Chen M.

Biochem Biophys Res Commun. 2015 Dec 25;468(4):541-7. doi: 10.1016/j.bbrc.2015.10.117. Epub 2015 Oct 24.


Role of Nrf2 in prevention of high-fat diet-induced obesity by synthetic triterpenoid CDDO-imidazolide.

Shin S, Wakabayashi J, Yates MS, Wakabayashi N, Dolan PM, Aja S, Liby KT, Sporn MB, Yamamoto M, Kensler TW.

Eur J Pharmacol. 2009 Oct 12;620(1-3):138-44. doi: 10.1016/j.ejphar.2009.08.022. Epub 2009 Aug 19.


17β-Estradiol up-regulates Nrf2 via PI3K/AKT and estrogen receptor signaling pathways to suppress light-induced degeneration in rat retina.

Zhu C, Wang S, Wang B, Du F, Hu C, Li H, Feng Y, Zhu R, Mo M, Cao Y, Li A, Yu X.

Neuroscience. 2015 Sep 24;304:328-39. doi: 10.1016/j.neuroscience.2015.07.057. Epub 2015 Jul 23.


Triterpenoids CDDO-ethyl amide and CDDO-trifluoroethyl amide improve the behavioral phenotype and brain pathology in a transgenic mouse model of Huntington's disease.

Stack C, Ho D, Wille E, Calingasan NY, Williams C, Liby K, Sporn M, Dumont M, Beal MF.

Free Radic Biol Med. 2010 Jul 15;49(2):147-58. doi: 10.1016/j.freeradbiomed.2010.03.017. Epub 2010 Mar 23.


Dimethyl fumarate and the oleanane triterpenoids, CDDO-imidazolide and CDDO-methyl ester, both activate the Nrf2 pathway but have opposite effects in the A/J model of lung carcinogenesis.

To C, Ringelberg CS, Royce DB, Williams CR, Risingsong R, Sporn MB, Liby KT.

Carcinogenesis. 2015 Jul;36(7):769-81. doi: 10.1093/carcin/bgv061. Epub 2015 May 4.


Guggulsterone induces heme oxygenase-1 expression through activation of Nrf2 in human mammary epithelial cells: PTEN as a putative target.

Almazari I, Park JM, Park SA, Suh JY, Na HK, Cha YN, Surh YJ.

Carcinogenesis. 2012 Feb;33(2):368-76. doi: 10.1093/carcin/bgr259. Epub 2011 Nov 17.


The triterpenoid CDDO-imidazolide confers potent protection against hyperoxic acute lung injury in mice.

Reddy NM, Suryanaraya V, Yates MS, Kleeberger SR, Hassoun PM, Yamamoto M, Liby KT, Sporn MB, Kensler TW, Reddy SP.

Am J Respir Crit Care Med. 2009 Nov 1;180(9):867-74. doi: 10.1164/rccm.200905-0670OC. Epub 2009 Aug 13.


Resveratrol prevents light-induced retinal degeneration via suppressing activator protein-1 activation.

Kubota S, Kurihara T, Ebinuma M, Kubota M, Yuki K, Sasaki M, Noda K, Ozawa Y, Oike Y, Ishida S, Tsubota K.

Am J Pathol. 2010 Oct;177(4):1725-31. doi: 10.2353/ajpath.2010.100098. Epub 2010 Aug 13.

Supplemental Content

Support Center