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Items: 1 to 20 of 103

1.

Stability of peroxide antimalarials in the presence of human hemoglobin.

Creek DJ, Ryan E, Charman WN, Chiu FC, Prankerd RJ, Vennerstrom JL, Charman SA.

Antimicrob Agents Chemother. 2009 Aug;53(8):3496-500. doi: 10.1128/AAC.00363-09. Epub 2009 Jun 1.

2.

Considerations on the mechanism of action of artemisinin antimalarials: part 1--the 'carbon radical' and 'heme' hypotheses.

Haynes RK, Cheu KW, N'Da D, Coghi P, Monti D.

Infect Disord Drug Targets. 2013 Aug;13(4):217-77. Review.

PMID:
24304352
3.

Heme as trigger and target for trioxane-containing antimalarial drugs.

Meunier B, Robert A.

Acc Chem Res. 2010 Nov 16;43(11):1444-51. doi: 10.1021/ar100070k. Epub 2010 Aug 30. Review.

PMID:
20804120
4.

Heme activates artemisinin more efficiently than hemin, inorganic iron, or hemoglobin.

Zhang S, Gerhard GS.

Bioorg Med Chem. 2008 Aug 15;16(16):7853-61. doi: 10.1016/j.bmc.2008.02.034. Epub 2008 Feb 14.

PMID:
18676152
5.

Alkylation of manganese(II) tetraphenylporphyrin by antimalarial fluorinated artemisinin derivatives.

Rodriguez M, Bonnet-Delpon D, Bégué JP, Robert A, Meunier B.

Bioorg Med Chem Lett. 2003 Mar 24;13(6):1059-62.

PMID:
12643911
6.

Comparison of the reactivity of antimalarial 1,2,4,5-tetraoxanes with 1,2,4-trioxolanes in the presence of ferrous iron salts, heme, and ferrous iron salts/phosphatidylcholine.

Bousejra-El Garah F, Wong MH, Amewu RK, Muangnoicharoen S, Maggs JL, Stigliani JL, Park BK, Chadwick J, Ward SA, O'Neill PM.

J Med Chem. 2011 Oct 13;54(19):6443-55. doi: 10.1021/jm200768h. Epub 2011 Sep 19.

PMID:
21888440
7.

Alkylation of human hemoglobin A0 by the antimalarial drug artemisinin.

Selmeczi K, Robert A, Claparols C, Meunier B.

FEBS Lett. 2004 Jan 2;556(1-3):245-8.

8.

Facile oxidation of leucomethylene blue and dihydroflavins by artemisinins: relationship with flavoenzyme function and antimalarial mechanism of action.

Haynes RK, Chan WC, Wong HN, Li KY, Wu WK, Fan KM, Sung HH, Williams ID, Prosperi D, Melato S, Coghi P, Monti D.

ChemMedChem. 2010 Aug 2;5(8):1282-99. doi: 10.1002/cmdc.201000225.

PMID:
20629071
9.
10.

[A quantum chemistry investigation on antimalarial mechanism of Qinghaosu based on cleavage of the peroxide bridge].

Liang RL, Liu TW, Qu LB, Tang MS, Xiang BR.

Yao Xue Xue Bao. 2006 Jun;41(6):544-7. Chinese.

PMID:
16927830
11.

Evidence that haem iron in the malaria parasite is not needed for the antimalarial effects of artemisinin.

Parapini S, Basilico N, Mondani M, Olliaro P, Taramelli D, Monti D.

FEBS Lett. 2004 Sep 24;575(1-3):91-4.

12.

Heme alkylation by artesunic acid and trioxaquine DU1301, two antimalarial trioxanes.

Laurent SA, Loup C, Mourgues S, Robert A, Meunier B.

Chembiochem. 2005 Apr;6(4):653-8.

PMID:
15744769
14.

Kinetics of iron-mediated artemisinin degradation: effect of solvent composition and iron salt.

Creek DJ, Chiu FC, Prankerd RJ, Charman SA, Charman WN.

J Pharm Sci. 2005 Aug;94(8):1820-9.

PMID:
15986470
15.

Quantum chemical study of the intermediate complex required for iron-mediated reactivity and antimalarial activity of dispiro-1,2,4-trioxolanes.

Creek DJ, Chalmers DK, Charman WN, Duke BJ.

J Mol Graph Model. 2008 Oct;27(3):394-400. doi: 10.1016/j.jmgm.2008.06.008. Epub 2008 Jul 9.

PMID:
18693050
16.

Alkylation of heme by the antimalarial drug artemisinin.

Robert A, Coppel Y, Meunier B.

Chem Commun (Camb). 2002 Mar 7;(5):414-5.

PMID:
12120518
17.

Reactions of antimalarial peroxides with each of leucomethylene blue and dihydroflavins: flavin reductase and the cofactor model exemplified.

Haynes RK, Cheu KW, Tang MM, Chen MJ, Guo ZF, Guo ZH, Coghi P, Monti D.

ChemMedChem. 2011 Feb 7;6(2):279-91. doi: 10.1002/cmdc.201000508. Epub 2010 Dec 23.

PMID:
21275052
18.

Modeling the decomposition mechanism of artemisinin.

Moles P, Oliva M, Safont VS.

J Phys Chem A. 2006 Jun 8;110(22):7144-58.

PMID:
16737265
19.

The reaction of artemisinins with hemoglobin: a unified picture.

Messori L, Gabbiani C, Casini A, Siragusa M, Vincieri FF, Bilia AR.

Bioorg Med Chem. 2006 May 1;14(9):2972-7. Epub 2006 Jan 10.

PMID:
16412643
20.

Interaction of artemisinins with oxyhemoglobin Hb-FeII, Hb-FeII, carboxyHb-FeII, heme-FeII, and carboxyheme FeII: significance for mode of action and implications for therapy of cerebral malaria.

Coghi P, Basilico N, Taramelli D, Chan WC, Haynes RK, Monti D.

ChemMedChem. 2009 Dec;4(12):2045-53. doi: 10.1002/cmdc.200900342.

PMID:
19844934

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