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Items: 1 to 20 of 113

1.

Pharmacologic inhibition of MEK and PI-3K converges on the mTOR/S6 pathway to decelerate cellular senescence.

Demidenko ZN, Shtutman M, Blagosklonny MV.

Cell Cycle. 2009 Jun 15;8(12):1896-900. Epub 2009 Jun 21.

PMID:
19478560
2.

Aging-suppressants: cellular senescence (hyperactivation) and its pharmacologic deceleration.

Blagosklonny MV.

Cell Cycle. 2009 Jun 15;8(12):1883-7. Epub 2009 Jun 21.

PMID:
19448395
5.

MEK drives cyclin D1 hyperelevation during geroconversion.

Leontieva OV, Demidenko ZN, Blagosklonny MV.

Cell Death Differ. 2013 Sep;20(9):1241-9. doi: 10.1038/cdd.2013.86. Epub 2013 Jul 12.

6.

Transformation by v-Src: Ras-MAPK and PI3K-mTOR mediate parallel pathways.

Penuel E, Martin GS.

Mol Biol Cell. 1999 Jun;10(6):1693-703.

7.

At concentrations that inhibit mTOR, resveratrol suppresses cellular senescence.

Demidenko ZN, Blagosklonny MV.

Cell Cycle. 2009 Jun 15;8(12):1901-4. Epub 2009 Jun 21.

PMID:
19471118
9.

Combined inhibition of MAPK and mTOR signaling inhibits growth, induces cell death, and abrogates invasive growth of melanoma cells.

Lasithiotakis KG, Sinnberg TW, Schittek B, Flaherty KT, Kulms D, Maczey E, Garbe C, Meier FE.

J Invest Dermatol. 2008 Aug;128(8):2013-23. doi: 10.1038/jid.2008.44. Epub 2008 Mar 6.

10.

U0126 reverses Ki-ras-mediated transformation by blocking both mitogen-activated protein kinase and p70 S6 kinase pathways.

Fukazawa H, Uehara Y.

Cancer Res. 2000 Apr 15;60(8):2104-7. Erratum in: Cancer Res 2000 Jul 1;60(13):3668.

11.

Longitudinal inhibition of PI3K/Akt/mTOR signaling by LY294002 and rapamycin induces growth arrest of adult T-cell leukemia cells.

Ikezoe T, Nishioka C, Bandobashi K, Yang Y, Kuwayama Y, Adachi Y, Takeuchi T, Koeffler HP, Taguchi H.

Leuk Res. 2007 May;31(5):673-82. Epub 2006 Sep 27.

PMID:
17007924
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15.

Targeting cancer stem cells in glioblastoma multiforme using mTOR inhibitors and the differentiating agent all-trans retinoic acid.

Friedman MD, Jeevan DS, Tobias M, Murali R, Jhanwar-Uniyal M.

Oncol Rep. 2013 Oct;30(4):1645-50. doi: 10.3892/or.2013.2625. Epub 2013 Jul 18.

PMID:
23877261
17.
19.

Lysophosphatidic acid 5 receptor induces activation of Na(+)/H(+) exchanger 3 via apical epidermal growth factor receptor in intestinal epithelial cells.

Yoo BK, He P, Lee SJ, Yun CC.

Am J Physiol Cell Physiol. 2011 Nov;301(5):C1008-16. doi: 10.1152/ajpcell.00231.2011. Epub 2011 Aug 10.

20.

Strain-induced vascular endothelial cell proliferation requires PI3K-dependent mTOR-4E-BP1 signal pathway.

Li W, Sumpio BE.

Am J Physiol Heart Circ Physiol. 2005 Apr;288(4):H1591-7. Epub 2004 Dec 9.

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