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Items: 1 to 20 of 156

1.

Gag- and Nef-specific CD4+ T cells recognize and inhibit SIV replication in infected macrophages early after infection.

Sacha JB, Giraldo-Vela JP, Buechler MB, Martins MA, Maness NJ, Chung C, Wallace LT, León EJ, Friedrich TC, Wilson NA, Hiraoka A, Watkins DI.

Proc Natl Acad Sci U S A. 2009 Jun 16;106(24):9791-6. doi: 10.1073/pnas.0813106106. Epub 2009 May 28.

2.

Nef Is Dispensable for Resistance of Simian Immunodeficiency Virus-Infected Macrophages to CD8+ T Cell Killing.

Rainho JN, Martins MA, Cunyat F, Watkins IT, Watkins DI, Stevenson M.

J Virol. 2015 Oct;89(20):10625-36. doi: 10.1128/JVI.01699-15. Epub 2015 Aug 12.

3.
4.

nef gene is required for robust productive infection by simian immunodeficiency virus of T-cell-rich paracortex in lymph nodes.

Sugimoto C, Tadakuma K, Otani I, Moritoyo T, Akari H, Ono F, Yoshikawa Y, Sata T, Izumo S, Mori K.

J Virol. 2003 Apr;77(7):4169-80.

5.

Reduced Simian Immunodeficiency Virus Replication in Macrophages of Sooty Mangabeys Is Associated with Increased Expression of Host Restriction Factors.

Mir KD, Mavigner M, Wang C, Paiardini M, Sodora DL, Chahroudi AM, Bosinger SE, Silvestri G.

J Virol. 2015 Oct;89(20):10136-44. doi: 10.1128/JVI.00710-15. Epub 2015 Jul 22.

6.

IL-15 treatment during acute simian immunodeficiency virus (SIV) infection increases viral set point and accelerates disease progression despite the induction of stronger SIV-specific CD8+ T cell responses.

Mueller YM, Do DH, Altork SR, Artlett CM, Gracely EJ, Katsetos CD, Legido A, Villinger F, Altman JD, Brown CR, Lewis MG, Katsikis PD.

J Immunol. 2008 Jan 1;180(1):350-60.

7.

Brain Macrophages in Simian Immunodeficiency Virus-Infected, Antiretroviral-Suppressed Macaques: a Functional Latent Reservoir.

Avalos CR, Abreu CM, Queen SE, Li M, Price S, Shirk EN, Engle EL, Forsyth E, Bullock BT, Mac Gabhann F, Wietgrefe SW, Haase AT, Zink MC, Mankowski JL, Clements JE, Gama L.

MBio. 2017 Aug 15;8(4). pii: e01186-17. doi: 10.1128/mBio.01186-17.

8.

Emergence of simian immunodeficiency virus-specific cytotoxic CD4+ T cells and increased humoral responses correlate with control of rebounding viremia in CD8-depleted macaques infected with Rev-independent live-attenuated simian immunodeficiency virus.

von Gegerfelt A, Valentin A, Alicea C, Van Rompay KK, Marthas ML, Montefiori DC, Pavlakis GN, Felber BK.

J Immunol. 2010 Sep 15;185(6):3348-58. doi: 10.4049/jimmunol.1000572. Epub 2010 Aug 11.

9.

The majority of freshly sorted simian immunodeficiency virus (SIV)-specific CD8(+) T cells cannot suppress viral replication in SIV-infected macrophages.

Vojnov L, Martins MA, Bean AT, Veloso de Santana MG, Sacha JB, Wilson NA, Bonaldo MC, Galler R, Stevenson M, Watkins DI.

J Virol. 2012 Apr;86(8):4682-7. doi: 10.1128/JVI.06324-11. Epub 2012 Feb 8.

10.

Quantitation of Productively Infected Monocytes and Macrophages of Simian Immunodeficiency Virus-Infected Macaques.

Avalos CR, Price SL, Forsyth ER, Pin JN, Shirk EN, Bullock BT, Queen SE, Li M, Gellerup D, O'Connor SL, Zink MC, Mankowski JL, Gama L, Clements JE.

J Virol. 2016 May 27;90(12):5643-5656. doi: 10.1128/JVI.00290-16. Print 2016 Jun 15.

11.

The antiviral efficacy of simian immunodeficiency virus-specific CD8+ T cells is unrelated to epitope specificity and is abrogated by viral escape.

Loffredo JT, Burwitz BJ, Rakasz EG, Spencer SP, Stephany JJ, Vela JP, Martin SR, Reed J, Piaskowski SM, Furlott J, Weisgrau KL, Rodrigues DS, Soma T, Napoé G, Friedrich TC, Wilson NA, Kallas EG, Watkins DI.

J Virol. 2007 Mar;81(6):2624-34. Epub 2006 Dec 27.

12.

Patterns of CD8+ immunodominance may influence the ability of Mamu-B*08-positive macaques to naturally control simian immunodeficiency virus SIVmac239 replication.

Loffredo JT, Bean AT, Beal DR, León EJ, May GE, Piaskowski SM, Furlott JR, Reed J, Musani SK, Rakasz EG, Friedrich TC, Wilson NA, Allison DB, Watkins DI.

J Virol. 2008 Feb;82(4):1723-38. Epub 2007 Dec 5.

13.

Inclusion of Vpr accessory gene in a plasmid vaccine cocktail markedly reduces Nef vaccine effectiveness in vivo resulting in CD4 cell loss and increased viral loads in rhesus macaques.

Muthumani K, Bagarazzi M, Conway D, Hwang DS, Ayyavoo V, Zhang D, Manson K, Kim J, Boyer J, Weiner DB.

J Med Primatol. 2002 Aug;31(4-5):179-85.

PMID:
12390540
14.

Long-term control of simian immunodeficiency virus replication with central memory CD4+ T-cell preservation after nonsterile protection by a cytotoxic T-lymphocyte-based vaccine.

Kawada M, Tsukamoto T, Yamamoto H, Takeda A, Igarashi H, Watkins DI, Matano T.

J Virol. 2007 May;81(10):5202-11. Epub 2007 Mar 7.

15.

CD8+ and CD4+ cytotoxic T cell escape mutations precede breakthrough SIVmac239 viremia in an elite controller.

Burwitz BJ, Giraldo-Vela JP, Reed J, Newman LP, Bean AT, Nimityongskul FA, Castrovinci PA, Maness NJ, Leon EJ, Rudersdorf R, Sacha JB.

Retrovirology. 2012 Nov 6;9:91. doi: 10.1186/1742-4690-9-91.

16.

Tissue-resident macrophages can contain replication-competent virus in antiretroviral-naive, SIV-infected Asian macaques.

DiNapoli SR, Ortiz AM, Wu F, Matsuda K, Twigg HL 3rd, Hirsch VM, Knox K, Brenchley JM.

JCI Insight. 2017 Feb 23;2(4):e91214. doi: 10.1172/jci.insight.91214.

17.

Identification of SIV Nef CD8(+) T cell epitopes restricted by a MHC class I haplotype associated with lower viral loads in a macaque AIDS model.

Nomura T, Yamamoto H, Takahashi N, Naruse TK, Kimura A, Matano T.

Biochem Biophys Res Commun. 2014 Jul 25;450(2):942-7. doi: 10.1016/j.bbrc.2014.06.072. Epub 2014 Jun 24.

PMID:
24971540
18.

Immunological and virological analyses of rhesus macaques immunized with chimpanzee adenoviruses expressing the simian immunodeficiency virus Gag/Tat fusion protein and challenged intrarectally with repeated low doses of SIVmac.

Cervasi B, Carnathan DG, Sheehan KM, Micci L, Paiardini M, Kurupati R, Tuyishime S, Zhou XY, Else JG, Ratcliffe SJ, Ertl HC, Silvestri G.

J Virol. 2013 Sep;87(17):9420-30. doi: 10.1128/JVI.01456-13. Epub 2013 Jun 26.

19.

Depletion of CD4⁺ T cells abrogates post-peak decline of viremia in SIV-infected rhesus macaques.

Ortiz AM, Klatt NR, Li B, Yi Y, Tabb B, Hao XP, Sternberg L, Lawson B, Carnathan PM, Cramer EM, Engram JC, Little DM, Ryzhova E, Gonzalez-Scarano F, Paiardini M, Ansari AA, Ratcliffe S, Else JG, Brenchley JM, Collman RG, Estes JD, Derdeyn CA, Silvestri G.

J Clin Invest. 2011 Nov;121(11):4433-45. doi: 10.1172/JCI46023. Epub 2011 Oct 17.

20.

Nef-mediated MHC class I down-regulation unmasks clonal differences in virus suppression by SIV-specific CD8(+) T cells independent of IFN-gamma and CD107a responses.

Minang JT, Trivett MT, Coren LV, Barsov EV, Piatak M Jr, Ott DE, Ohlen C.

Virology. 2009 Aug 15;391(1):130-9. doi: 10.1016/j.virol.2009.06.008. Epub 2009 Jun 24.

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