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Therapeutic efficacy of seliciclib in combination with ionizing radiation for human nasopharyngeal carcinoma.

Hui AB, Yue S, Shi W, Alajez NM, Ito E, Green SR, Frame S, O'Sullivan B, Liu FF.

Clin Cancer Res. 2009 Jun 1;15(11):3716-24. doi: 10.1158/1078-0432.CCR-08-2790. Epub 2009 May 26.


Pharmacodynamic effects of seliciclib, an orally administered cell cycle modulator, in undifferentiated nasopharyngeal cancer.

Hsieh WS, Soo R, Peh BK, Loh T, Dong D, Soh D, Wong LS, Green S, Chiao J, Cui CY, Lai YF, Lee SC, Mow B, Soong R, Salto-Tellez M, Goh BC.

Clin Cancer Res. 2009 Feb 15;15(4):1435-42. doi: 10.1158/1078-0432.CCR-08-1748.


Combination bcl-2 antisense and radiation therapy for nasopharyngeal cancer.

Yip KW, Mocanu JD, Au PY, Sleep GT, Huang D, Busson P, Yeh WC, Gilbert R, O'Sullivan B, Gullane P, Bastianutto C, Liu FF.

Clin Cancer Res. 2005 Nov 15;11(22):8131-44.


Seliciclib (CYC202 or R-roscovitine), a small-molecule cyclin-dependent kinase inhibitor, mediates activity via down-regulation of Mcl-1 in multiple myeloma.

Raje N, Kumar S, Hideshima T, Roccaro A, Ishitsuka K, Yasui H, Shiraishi N, Chauhan D, Munshi NC, Green SR, Anderson KC.

Blood. 2005 Aug 1;106(3):1042-7. Epub 2005 Apr 12.


Enhanced therapeutic efficacy of adenovirus-mediated interleukin-24 gene therapy combined with ionizing radiotherapy for nasopharyngeal carcinoma.

Liu J, Zhang Y, Sun P, Xie Y, Xiang J, Yang J.

Oncol Rep. 2013 Sep;30(3):1165-74. doi: 10.3892/or.2013.2550. Epub 2013 Jun 19.


Seliciclib (CYC202, R-Roscovitine) induces cell death in multiple myeloma cells by inhibition of RNA polymerase II-dependent transcription and down-regulation of Mcl-1.

MacCallum DE, Melville J, Frame S, Watt K, Anderson S, Gianella-Borradori A, Lane DP, Green SR.

Cancer Res. 2005 Jun 15;65(12):5399-407.


Antiviral agent cidofovir decreases Epstein-Barr virus (EBV) oncoproteins and enhances the radiosensitivity in EBV-related malignancies.

Abdulkarim B, Sabri S, Zelenika D, Deutsch E, Frascogna V, Klijanienko J, Vainchenker W, Joab I, Bourhis J.

Oncogene. 2003 Apr 17;22(15):2260-71.


Potential efficacy of p16 gene therapy for EBV-positive nasopharyngeal carcinoma.

Li AA, Ng E, Shi W, Lee A, Chia M, Liu TJ, Huang D, O'Sullivan B, Gullane P, Liu FF.

Int J Cancer. 2004 Jun 20;110(3):452-8.


Perillyl alcohol and perillic acid induced cell cycle arrest and apoptosis in non small cell lung cancer cells.

Yeruva L, Pierre KJ, Elegbede A, Wang RC, Carper SW.

Cancer Lett. 2007 Nov 18;257(2):216-26. Epub 2007 Sep 20.


Induction of G2/M arrest and apoptosis by water extract of Strychni Semen in human gastric carcinoma AGS cells.

Lee SM, Kwon JI, Choi YH, Eom HS, Chi GY.

Phytother Res. 2008 Jun;22(6):752-8. doi: 10.1002/ptr.2355.


Celecoxib enhances radiosensitivity via induction of G₂-M phase arrest and apoptosis in nasopharyngeal carcinoma.

Zhang SX, Qiu QH, Chen WB, Liang CH, Huang B.

Cell Physiol Biochem. 2014;33(5):1484-97. doi: 10.1159/000358713. Epub 2014 May 9. Erratum in: Cell Physiol Biochem. 2015;35(6):2501.


Histone deacetylase inhibitor NVP-LAQ824 sensitizes human nonsmall cell lung cancer to the cytotoxic effects of ionizing radiation.

Cuneo KC, Fu A, Osusky K, Huamani J, Hallahan DE, Geng L.

Anticancer Drugs. 2007 Aug;18(7):793-800.


The synthesized 2-(2-fluorophenyl)-6,7-methylenedioxyquinolin-4-one (CHM-1) promoted G2/M arrest through inhibition of CDK1 and induced apoptosis through the mitochondrial-dependent pathway in CT-26 murine colorectal adenocarcinoma cells.

Chou LC, Yang JS, Huang LJ, Wu HC, Lu CC, Chiang JH, Chen KT, Kuo SC, Chung JG.

J Gastroenterol. 2009;44(10):1055-63. doi: 10.1007/s00535-009-0111-1. Epub 2009 Aug 14.


The mechanism of acacetin-induced apoptosis on oral squamous cell carcinoma.

Kim CD, Cha JD, Li S, Cha IH.

Arch Oral Biol. 2015 Sep;60(9):1283-98. doi: 10.1016/j.archoralbio.2015.05.009. Epub 2015 Jun 8.


AZD5438, an inhibitor of Cdk1, 2, and 9, enhances the radiosensitivity of non-small cell lung carcinoma cells.

Raghavan P, Tumati V, Yu L, Chan N, Tomimatsu N, Burma S, Bristow RG, Saha D.

Int J Radiat Oncol Biol Phys. 2012 Nov 15;84(4):e507-14. doi: 10.1016/j.ijrobp.2012.05.035. Epub 2012 Jul 12.


The natural compound gambogic acid radiosensitizes nasopharyngeal carcinoma cells under hypoxic conditions.

Yang M, Yang Y, Cui H, Guan Z, Yang Y, Zhang H, Chen X, Zhu H, Yang X, Cai J, Cheng H, Sun X.

Tumori. 2016 Mar-Apr;102(2):135-43. doi: 10.5301/tj.5000411. Epub 2015 Sep 10.


In vitro activity of cyclin-dependent kinase inhibitor CYC202 (Seliciclib, R-roscovitine) in mantle cell lymphomas.

Lacrima K, Valentini A, Lambertini C, Taborelli M, Rinaldi A, Zucca E, Catapano C, Cavalli F, Gianella-Borradori A, Maccallum DE, Bertoni F.

Ann Oncol. 2005 Jul;16(7):1169-76. Epub 2005 Apr 25.


Silencing of LMP1 induces cell cycle arrest and enhances chemosensitivity through inhibition of AKT signaling pathway in EBV-positive nasopharyngeal carcinoma cells.

Mei YP, Zhou JM, Wang Y, Huang H, Deng R, Feng GK, Zeng YX, Zhu XF.

Cell Cycle. 2007 Jun 1;6(11):1379-85. Epub 2007 Jun 11.


Activation of lytic cycle of Epstein-Barr virus by suberoylanilide hydroxamic acid leads to apoptosis and tumor growth suppression of nasopharyngeal carcinoma.

Hui KF, Ho DN, Tsang CM, Middeldorp JM, Tsao GS, Chiang AK.

Int J Cancer. 2012 Oct 15;131(8):1930-40. doi: 10.1002/ijc.27439. Epub 2012 Mar 8.

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