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Common mechanisms of PIKK regulation.

Lovejoy CA, Cortez D.

DNA Repair (Amst). 2009 Sep 2;8(9):1004-8. doi: 10.1016/j.dnarep.2009.04.006. Epub 2009 May 21. Review.


Tel2 regulates the stability of PI3K-related protein kinases.

Takai H, Wang RC, Takai KK, Yang H, de Lange T.

Cell. 2007 Dec 28;131(7):1248-59.


Regulation of the Target of Rapamycin and Other Phosphatidylinositol 3-Kinase-Related Kinases by Membrane Targeting.

De Cicco M, Rahim MS, Dames SA.

Membranes (Basel). 2015 Sep 29;5(4):553-75. doi: 10.3390/membranes5040553. Review.


The role of NBS1 in the modulation of PIKK family proteins ATM and ATR in the cellular response to DNA damage.

Zhou J, Lim CU, Li JJ, Cai L, Zhang Y.

Cancer Lett. 2006 Nov 8;243(1):9-15. Epub 2006 Mar 10. Review.


Integrated regulation of PIKK-mediated stress responses by AAA+ proteins RUVBL1 and RUVBL2.

Izumi N, Yamashita A, Ohno S.

Nucleus. 2012 Jan-Feb;3(1):29-43. doi: 10.4161/nucl.18926. Review.


Activation of ATR and related PIKKs.

Mordes DA, Cortez D.

Cell Cycle. 2008 Sep 15;7(18):2809-12. Epub 2008 Sep 30.


Depletion of ATR selectively sensitizes ATM-deficient human mammary epithelial cells to ionizing radiation and DNA-damaging agents.

Cui Y, Palii SS, Innes CL, Paules RS.

Cell Cycle. 2014;13(22):3541-50. doi: 10.4161/15384101.2014.960729.


TopBP1 activates ATR through ATRIP and a PIKK regulatory domain.

Mordes DA, Glick GG, Zhao R, Cortez D.

Genes Dev. 2008 Jun 1;22(11):1478-89. doi: 10.1101/gad.1666208.


Phosphatidylinositide 3-kinase (PI3K) and PI3K-related kinase (PIKK) activity contributes to radioresistance in thyroid carcinomas.

Burrows N, Williams J, Telfer BA, Resch J, Valentine HR, Fitzmaurice RJ, Eustace A, Irlam J, Rowling EJ, Hoang-Vu C, West CM, Brabant G, Williams KJ.

Oncotarget. 2016 Sep 27;7(39):63106-63123. doi: 10.18632/oncotarget.11056.


DNA double-strand break formation upon UV-induced replication stress activates ATM and DNA-PKcs kinases.

Yajima H, Lee KJ, Zhang S, Kobayashi J, Chen BP.

J Mol Biol. 2009 Jan 23;385(3):800-10. doi: 10.1016/j.jmb.2008.11.036. Epub 2008 Nov 27.


Investigation of switch from ATM to ATR signaling at the sites of DNA damage induced by low and high LET radiation.

Saha J, Wang M, Cucinotta FA.

DNA Repair (Amst). 2013 Dec;12(12):1143-51. doi: 10.1016/j.dnarep.2013.10.004. Epub 2013 Nov 12.


Inhibition of phosphoinositide 3-kinase related kinases by the radiosensitizing agent wortmannin.

Sarkaria JN, Tibbetts RS, Busby EC, Kennedy AP, Hill DE, Abraham RT.

Cancer Res. 1998 Oct 1;58(19):4375-82.


Polo-like kinase 1 inactivation following mitotic DNA damaging treatments is independent of ataxia telangiectasia mutated kinase.

Yuan JH, Feng Y, Fisher RH, Maloid S, Longo DL, Ferris DK.

Mol Cancer Res. 2004 Jul;2(7):417-26.


PDK2: the missing piece in the receptor tyrosine kinase signaling pathway puzzle.

Dong LQ, Liu F.

Am J Physiol Endocrinol Metab. 2005 Aug;289(2):E187-96. Review.


Take your PIKK: tumour viruses and DNA damage response pathways.

Pancholi NJ, Price AM, Weitzman MD.

Philos Trans R Soc Lond B Biol Sci. 2017 Oct 19;372(1732). pii: 20160269. doi: 10.1098/rstb.2016.0269. Review.


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