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Items: 1 to 20 of 142

1.

Activation of human monocytes by live Borrelia burgdorferi generates TLR2-dependent and -independent responses which include induction of IFN-beta.

Salazar JC, Duhnam-Ems S, La Vake C, Cruz AR, Moore MW, Caimano MJ, Velez-Climent L, Shupe J, Krueger W, Radolf JD.

PLoS Pathog. 2009 May;5(5):e1000444. doi: 10.1371/journal.ppat.1000444. Epub 2009 May 22.

2.

Phagosomal signaling by Borrelia burgdorferi in human monocytes involves Toll-like receptor (TLR) 2 and TLR8 cooperativity and TLR8-mediated induction of IFN-beta.

Cervantes JL, Dunham-Ems SM, La Vake CJ, Petzke MM, Sahay B, Sellati TJ, Radolf JD, Salazar JC.

Proc Natl Acad Sci U S A. 2011 Mar 1;108(9):3683-8. doi: 10.1073/pnas.1013776108. Epub 2011 Feb 14.

3.

Human TLR8 is activated upon recognition of Borrelia burgdorferi RNA in the phagosome of human monocytes.

Cervantes JL, La Vake CJ, Weinerman B, Luu S, O'Connell C, Verardi PH, Salazar JC.

J Leukoc Biol. 2013 Dec;94(6):1231-41. doi: 10.1189/jlb.0413206. Epub 2013 Aug 1.

4.

Live Borrelia burgdorferi spirochetes elicit inflammatory mediators from human monocytes via the Toll-like receptor signaling pathway.

Dennis VA, Dixit S, O'Brien SM, Alvarez X, Pahar B, Philipp MT.

Infect Immun. 2009 Mar;77(3):1238-45. doi: 10.1128/IAI.01078-08. Epub 2009 Jan 12.

5.

Borrelia burgdorferi RNA induces type I and III interferons via Toll-like receptor 7 and contributes to production of NF-κB-dependent cytokines.

Love AC, Schwartz I, Petzke MM.

Infect Immun. 2014 Jun;82(6):2405-16. doi: 10.1128/IAI.01617-14. Epub 2014 Mar 24.

6.

Toll-like receptor 2 is required for innate, but not acquired, host defense to Borrelia burgdorferi.

Wooten RM, Ma Y, Yoder RA, Brown JP, Weis JH, Zachary JF, Kirschning CJ, Weis JJ.

J Immunol. 2002 Jan 1;168(1):348-55.

7.

Phagocytosis of Borrelia burgdorferi and Treponema pallidum potentiates innate immune activation and induces gamma interferon production.

Moore MW, Cruz AR, LaVake CJ, Marzo AL, Eggers CH, Salazar JC, Radolf JD.

Infect Immun. 2007 Apr;75(4):2046-62. Epub 2007 Jan 12.

8.

Phagocytosis of Borrelia burgdorferi, the Lyme disease spirochete, potentiates innate immune activation and induces apoptosis in human monocytes.

Cruz AR, Moore MW, La Vake CJ, Eggers CH, Salazar JC, Radolf JD.

Infect Immun. 2008 Jan;76(1):56-70. Epub 2007 Oct 15.

9.
10.

Borrelia burgdorferi lipoprotein-mediated TLR2 stimulation causes the down-regulation of TLR5 in human monocytes.

Cabral ES, Gelderblom H, Hornung RL, Munson PJ, Martin R, Marques AR.

J Infect Dis. 2006 Mar 15;193(6):849-59. Epub 2006 Feb 8.

PMID:
16479520
11.

TLR8 Senses Staphylococcus aureus RNA in Human Primary Monocytes and Macrophages and Induces IFN-β Production via a TAK1-IKKβ-IRF5 Signaling Pathway.

Bergstrøm B, Aune MH, Awuh JA, Kojen JF, Blix KJ, Ryan L, Flo TH, Mollnes TE, Espevik T, Stenvik J.

J Immunol. 2015 Aug 1;195(3):1100-11. doi: 10.4049/jimmunol.1403176. Epub 2015 Jun 17.

12.

Systematic analysis highlights the key role of TLR2/NF-kappaB/MAP kinase signaling for IL-8 induction by macrophage-like THP-1 cells under influence of Borrelia burgdorferi lysates.

Sadik CD, Hunfeld KP, Bachmann M, Kraiczy P, Eberhardt W, Brade V, Pfeilschifter J, Mühl H.

Int J Biochem Cell Biol. 2008;40(11):2508-21. doi: 10.1016/j.biocel.2008.04.014. Epub 2008 May 16.

PMID:
18571457
14.

Borrelia burgdorferi elicited-IL-10 suppresses the production of inflammatory mediators, phagocytosis, and expression of co-stimulatory receptors by murine macrophages and/or dendritic cells.

Chung Y, Zhang N, Wooten RM.

PLoS One. 2013 Dec 19;8(12):e84980. doi: 10.1371/journal.pone.0084980. eCollection 2013. Erratum in: PLoS One. 2014;9(1). doi:10.1371/annotation/2ce59bc4-fcf0-498f-86f0-376432428bf4. PLoS One. 2014;9(1). doi:10.1371/annotation/680090aa-3e1b-4135-94d6-8082c09180d4.

15.

Different patterns of expression and of IL-10 modulation of inflammatory mediators from macrophages of Lyme disease-resistant and -susceptible mice.

Gautam A, Dixit S, Embers M, Gautam R, Philipp MT, Singh SR, Morici L, Dennis VA.

PLoS One. 2012;7(9):e43860. Epub 2012 Sep 14.

16.
17.

Induction of pro- and anti-inflammatory cytokines by Borrelia burgdorferi lipoproteins in monocytes is mediated by CD14.

Giambartolomei GH, Dennis VA, Lasater BL, Philipp MT.

Infect Immun. 1999 Jan;67(1):140-7.

18.

Distinct roles for MyD88 and Toll-like receptors 2, 5, and 9 in phagocytosis of Borrelia burgdorferi and cytokine induction.

Shin OS, Isberg RR, Akira S, Uematsu S, Behera AK, Hu LT.

Infect Immun. 2008 Jun;76(6):2341-51. doi: 10.1128/IAI.01600-07. Epub 2008 Mar 31.

19.

TLR1/TLR2 heterodimers play an important role in the recognition of Borrelia spirochetes.

Oosting M, Ter Hofstede H, Sturm P, Adema GJ, Kullberg BJ, van der Meer JW, Netea MG, Joosten LA.

PLoS One. 2011;6(10):e25998. doi: 10.1371/journal.pone.0025998. Epub 2011 Oct 5.

20.

Vibrio cholerae porin OmpU mediates M1-polarization of macrophages/monocytes via TLR1/TLR2 activation.

Khan J, Sharma PK, Mukhopadhaya A.

Immunobiology. 2015 Nov;220(11):1199-209. doi: 10.1016/j.imbio.2015.06.009. Epub 2015 Jun 5.

PMID:
26093918

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