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Items: 1 to 20 of 236

1.

On the mechanism of autoinhibition of the RhoA-specific nucleotide exchange factor PDZRhoGEF.

Zheng M, Cierpicki T, Momotani K, Artamonov MV, Derewenda U, Bushweller JH, Somlyo AV, Derewenda ZS.

BMC Struct Biol. 2009 May 21;9:36. doi: 10.1186/1472-6807-9-36.

2.

Insights into the molecular activation mechanism of the RhoA-specific guanine nucleotide exchange factor, PDZRhoGEF.

Bielnicki JA, Shkumatov AV, Derewenda U, Somlyo AV, Svergun DI, Derewenda ZS.

J Biol Chem. 2011 Oct 7;286(40):35163-75. doi: 10.1074/jbc.M111.270918. Epub 2011 Aug 4.

3.

Mechanistic insights into specificity, activity, and regulatory elements of the regulator of G-protein signaling (RGS)-containing Rho-specific guanine nucleotide exchange factors (GEFs) p115, PDZ-RhoGEF (PRG), and leukemia-associated RhoGEF (LARG).

Jaiswal M, Gremer L, Dvorsky R, Haeusler LC, Cirstea IC, Uhlenbrock K, Ahmadian MR.

J Biol Chem. 2011 May 20;286(20):18202-12. doi: 10.1074/jbc.M111.226431. Epub 2011 Mar 28.

4.

Real-time NMR study of guanine nucleotide exchange and activation of RhoA by PDZ-RhoGEF.

Gasmi-Seabrook GM, Marshall CB, Cheung M, Kim B, Wang F, Jang YJ, Mak TW, Stambolic V, Ikura M.

J Biol Chem. 2010 Feb 19;285(8):5137-45. doi: 10.1074/jbc.M109.064691. Epub 2009 Dec 17.

5.

Critical role of the pleckstrin homology and cysteine-rich domains in Vav signaling and transforming activity.

Palmby TR, Abe K, Der CJ.

J Biol Chem. 2002 Oct 18;277(42):39350-9. Epub 2002 Aug 12.

6.
7.

The molecular basis of RhoA specificity in the guanine nucleotide exchange factor PDZ-RhoGEF.

Oleksy A, Opaliński Ł, Derewenda U, Derewenda ZS, Otlewski J.

J Biol Chem. 2006 Oct 27;281(43):32891-7. Epub 2006 Sep 5.

8.

A novel PDZ domain containing guanine nucleotide exchange factor links heterotrimeric G proteins to Rho.

Fukuhara S, Murga C, Zohar M, Igishi T, Gutkind JS.

J Biol Chem. 1999 Feb 26;274(9):5868-79.

9.

The solution structure and dynamics of the DH-PH module of PDZRhoGEF in isolation and in complex with nucleotide-free RhoA.

Cierpicki T, Bielnicki J, Zheng M, Gruszczyk J, Kasterka M, Petoukhov M, Zhang A, Fernandez EJ, Svergun DI, Derewenda U, Bushweller JH, Derewenda ZS.

Protein Sci. 2009 Oct;18(10):2067-79. doi: 10.1002/pro.219.

10.

Role of the C-terminal SH3 domain and N-terminal tyrosine phosphorylation in regulation of Tim and related Dbl-family proteins.

Yohe ME, Rossman K, Sondek J.

Biochemistry. 2008 Jul 1;47(26):6827-39. doi: 10.1021/bi702543p. Epub 2008 Jun 7.

11.

Structural determinants of RhoA binding and nucleotide exchange in leukemia-associated Rho guanine-nucleotide exchange factor.

Kristelly R, Gao G, Tesmer JJ.

J Biol Chem. 2004 Nov 5;279(45):47352-62. Epub 2004 Aug 25.

12.

The DH and PH domains of Trio coordinately engage Rho GTPases for their efficient activation.

Chhatriwala MK, Betts L, Worthylake DK, Sondek J.

J Mol Biol. 2007 May 18;368(5):1307-20. Epub 2007 Feb 22.

13.

Activated RhoA binds to the pleckstrin homology (PH) domain of PDZ-RhoGEF, a potential site for autoregulation.

Chen Z, Medina F, Liu MY, Thomas C, Sprang SR, Sternweis PC.

J Biol Chem. 2010 Jul 2;285(27):21070-81. doi: 10.1074/jbc.M110.122549. Epub 2010 Apr 29.

14.

Scambio, a novel guanine nucleotide exchange factor for Rho.

Curtis C, Hemmeryckx B, Haataja L, Senadheera D, Groffen J, Heisterkamp N.

Mol Cancer. 2004 Apr 23;3:10.

15.

Plexin B regulates Rho through the guanine nucleotide exchange factors leukemia-associated Rho GEF (LARG) and PDZ-RhoGEF.

Perrot V, Vazquez-Prado J, Gutkind JS.

J Biol Chem. 2002 Nov 8;277(45):43115-20. Epub 2002 Aug 14.

16.

A conserved hydrophobic surface of the LARG pleckstrin homology domain is critical for RhoA activation in cells.

Aittaleb M, Gao G, Evelyn CR, Neubig RR, Tesmer JJ.

Cell Signal. 2009 Nov;21(11):1569-78. doi: 10.1016/j.cellsig.2009.06.003. Epub 2009 Jun 26.

17.

Activation of the exchange factor Ras-GRF by calcium requires an intact Dbl homology domain.

Freshney NW, Goonesekera SD, Feig LA.

FEBS Lett. 1997 Apr 21;407(1):111-5.

18.

Modulation of a GEF switch: autoinhibition of the intrinsic guanine nucleotide exchange activity of p115-RhoGEF.

Chen Z, Guo L, Sprang SR, Sternweis PC.

Protein Sci. 2011 Jan;20(1):107-17. doi: 10.1002/pro.542.

19.

Identification of potential mechanisms for regulation of p115 RhoGEF through analysis of endogenous and mutant forms of the exchange factor.

Wells CD, Gutowski S, Bollag G, Sternweis PC.

J Biol Chem. 2001 Aug 3;276(31):28897-905. Epub 2001 May 30.

20.

CZH proteins: a new family of Rho-GEFs.

Meller N, Merlot S, Guda C.

J Cell Sci. 2005 Nov 1;118(Pt 21):4937-46. Review.

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